Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Shuya, Shioda"'
Autor:
Haruna Ebisu, Kana Shintani, Takumi Chinen, Yoko Nagumo, Shuya Shioda, Taisei Hatanaka, Akira Sakakura, Ichiro Hayakawa, Hideo Kigoshi, Takeo Usui
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
α/β-Tubulin inhibitors that alter microtubule (MT) dynamics are commonly used in cancer therapy, however, these inhibitors also cause severe side effects such as peripheral neuropathy. γ-Tubulin is a possible target as antitumor drugs with low sid
Externí odkaz:
https://doaj.org/article/538758ef14db4b708215884f46c3aa3d
Autor:
Ichiro Hayakawa, Shuya Shioda, Takumi Chinen, Hideo Kigoshi, Takeo Usui, Akira Sakakura, Haruna Ebisu, Taisei Hatanaka
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:5639-5645
We have discovered O6-benzyl glaziovianin A, which showed stronger inhibition of microtubule polymerization (IC50 = 2.1 μM) than known α,β-tubulin inhibitors, such as colchicine and glaziovianin A. Also, we performed competition binding experiment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f99350f86169976da717630c6b510b5e
https://doi.org/10.1016/j.bmc.2016.09.026
https://doi.org/10.1016/j.bmc.2016.09.026
Publikováno v:
Bulletin of the Chemical Society of Japan. 87:544-549
Glaziovianin A and its O7-propargyl analogue are potent cytotoxic isoflavones. We found that the O7-propargyl analogue completely arrested cell-cycle progression. We have achieved the large-scale s...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29edff18376d781b1e2e9152fff4ed15
https://doi.org/10.1246/bcsj.20130342
https://doi.org/10.1246/bcsj.20130342
Autor:
Ichiro, Hayakawa, Shuya, Shioda, Takumi, Chinen, Taisei, Hatanaka, Haruna, Ebisu, Akira, Sakakura, Takeo, Usui, Hideo, Kigoshi
Publikováno v:
Bioorganicmedicinal chemistry. 24(21)
We have discovered O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d1a83964b7a77270c43586f7f01eebfc
https://pubmed.ncbi.nlm.nih.gov/27665177
https://pubmed.ncbi.nlm.nih.gov/27665177
Publikováno v:
HETEROCYCLES. 99:238
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c95268a25c021f2740f4df8e9cd27986
https://doi.org/10.3987/com-18-s(f)16
https://doi.org/10.3987/com-18-s(f)16
Autor:
Judith Pagel, Haruka Takeno, Elmar Schiebel, Tien-chen Lin, Yoshiki Hayashi, Peng Liu, Hideo Kigoshi, Yasushi Okada, Tomohiro Shima, Shuya Shioda, Oliver J. Gruss, Berati Cerikan, Ichiro Hayakawa, Yoshio Hayashi, Takeo Usui, Takumi Chinen
Publikováno v:
Nature Communications
Inhibitors of microtubule (MT) assembly or dynamics that target α/β-tubulin are widely exploited in cancer therapy and biological research. However, specific inhibitors of the MT nucleator γ-tubulin that would allow testing temporal functions of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41976e7d7a6ba2239a8024867f63f1ab
https://doi.org/10.1038/ncomms9722
https://doi.org/10.1038/ncomms9722