Zobrazeno 1 - 10
of 190
pro vyhledávání: '"Shuxing Zhang"'
Autor:
Xiaowen Liang, Sung Yun Jung, Lon Wolf Fong, Gamze Bildik, Joshua P. Gray, Weiqun Mao, Shuxing Zhang, Steven W. Millward, Alemayehu A. Gorfe, Yong Zhou, Zhen Lu, Robert C. Bast, Jr.
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108151- (2023)
Summary: DIRAS3 is an imprinted tumor suppressor gene encoding a GTPase that has a distinctive N-terminal extension (NTE) not found in other RAS proteins. This NTE and the prenylated C-terminus are required for DIRAS3-mediated inhibition of RAS/MAP s
Externí odkaz:
https://doaj.org/article/70cacc6af2444e3e920cbf39c22bbaf4
Autor:
Lin Zhang, Jingkun Qu, Yutao Qi, Yimin Duan, Yu-Wen Huang, Zhifen Zhou, Ping Li, Jun Yao, Beibei Huang, Shuxing Zhang, Dihua Yu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Breast cancer cells are known to metastasize to the bone but why the cells should migrate and metastasize to this particular organ is not clearly understood. Here, the authors show that EZH2 activates an integrin B1 and FAK signaling pathway in breas
Externí odkaz:
https://doaj.org/article/05aa232c6afd450daf8510c54d82f59b
Publikováno v:
Frontiers in Artificial Intelligence, Vol 6 (2023)
Accurate prediction of drug response is a crucial step in personalized medicine. Recently, deep learning techniques have been witnessed with significant breakthroughs in a variety of areas including biomedical research and chemogenomic applications.
Externí odkaz:
https://doaj.org/article/b941bc3e92624fdd80e4d73d6efac31b
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract The ubiquitination of SKP2, an oncoprotein, is controlled by its E3 ligases, including APC/CFZR1 and deubiquitinases such as USP10. We identified a two-gene signature for the ubiquitination of SKP2, consisting of the copy number of FZR1 comp
Externí odkaz:
https://doaj.org/article/1149c03f182b47339501a7bdd90c293f
Publikováno v:
Entropy, Vol 24, Iss 10, p 1438 (2022)
Dimethyl carbonate is an important green chemical that has been widely used in the chemical industry. In the production of dimethyl carbonate, methanol oxidative carbonylation has been studied, but the conversion ratio of dimethyl carbonate using thi
Externí odkaz:
https://doaj.org/article/f20d3eb053c1408d92928cac5493eed4
Autor:
Nan Li, Yifan Wang, Shinya Neri, Yuanli Zhen, Lon Wolf R. Fong, Yawei Qiao, Xu Li, Zhen Chen, Clifford Stephan, Weiye Deng, Rui Ye, Wen Jiang, Shuxing Zhang, Yonghao Yu, Mien-Chie Hung, Junjie Chen, Steven H. Lin
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The LKB1/AMPK is crucial for maintaining cellular homeostasis and is often deregulated in tumours. Here, the authors show that the ribosylation of LKB1 by tankyrase-RNF146 axis results in attenuation of LKB1 pathway activation.
Externí odkaz:
https://doaj.org/article/9b4222506e07478e9b0dbb2ab2af74f5
Autor:
Fei Han, Chien-Feng Li, Zhen Cai, Xian Zhang, Guoxiang Jin, Wei-Na Zhang, Chuan Xu, Chi-Yun Wang, John Morrow, Shuxing Zhang, Dazhi Xu, Guihua Wang, Hui-Kuan Lin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
How Akt pathway is activated under stress is poorly understood. Here, the authors demonstrate the crucial role of AMPK for cellular stresses and growth factors- mediated Akt activation through a mechanism involving the E3 ubiquitin ligase Skp2 and Cu
Externí odkaz:
https://doaj.org/article/61bf2407c8eb4a9eb5d46d59f18432bf
Autor:
Ivan Vannini, Petra M. Wise, Kishore B. Challagundla, Meropi Plousiou, Mirco Raffini, Erika Bandini, Francesca Fanini, Giorgia Paliaga, Melissa Crawford, Manuela Ferracin, Cristina Ivan, Linda Fabris, Ramana V. Davuluri, Zhiyi Guo, Maria Angelica Cortez, Xinna Zhang, Lu Chen, Shuxing Zhang, Cecilia Fernandez-Cymering, Leng Han, Silvia Carloni, Samanta Salvi, Hui Ling, Mariam Murtadha, Paolo Neviani, Barbara J. Gitlitz, Ite A. Laird-Offringa, Patrick Nana-Sinkam, Massimo Negrini, Han Liang, Dino Amadori, Amelia Cimmino, George A. Calin, Muller Fabbri
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
T-UCRs encode long non-coding RNAs implicated in human carcinogenesis, but the underlying mechanisms are poorly understood. Here, the authors identify uc.339 as an oncogene in lung cancer that is upregulated through the loss of TP53 and promotes Cycl
Externí odkaz:
https://doaj.org/article/20f421d598244afda24290cb099f73c7
Autor:
Hua Xiao, Patrick K. T. Shiu, Jun Shu, Gaetano Santulli, Mohammad K. Gheybi, Simon J. Conn, Baptiste Bogard, Florent Hubé, Joseph H. Taube, Sendurai A. Mani, Luo Song, George A. Calin, Shuxing Zhang
Publikováno v:
Non-Coding RNA, Vol 4, Iss 3, p 23 (2018)
We are delighted to share with you our sixth Journal Club and highlight some of the most interesting papers published recently [...]
Externí odkaz:
https://doaj.org/article/2f252c4eb3b24d91b6f752cf8c2f6755
Autor:
Ivan Vannini, Petra M. Wise, Kishore B. Challagundla, Meropi Plousiou, Mirco Raffini, Erika Bandini, Francesca Fanini, Giorgia Paliaga, Melissa Crawford, Manuela Ferracin, Cristina Ivan, Linda Fabris, Ramana V. Davuluri, Zhiyi Guo, Maria Angelica Cortez, Xinna Zhang, Lu Chen, Shuxing Zhang, Cecilia Fernandez-Cymering, Leng Han, Silvia Carloni, Samanta Salvi, Hui Ling, Mariam Murtadha, Paolo Neviani, Barbara J. Gitlitz, Ite A. Laird-Offringa, Patrick Nana-Sinkam, Massimo Negrini, Han Liang, Dino Amadori, Amelia Cimmino, George A. Calin, Muller Fabbri
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
In the originally published version of this Article, the positions of the final two authors in the author list were inadvertently inverted during the production process. This error has now been corrected in both the PDF and HTML versions of the Artic
Externí odkaz:
https://doaj.org/article/c7458f30c35649ddb2779a40d016a738