Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Shuwen Rao"'
Autor:
Qiaoyun Song, Haoyue Zhu, Manlan Qiu, Jialiao Cai, Yun Hu, Haixia Yang, Shuwen Rao, Yaolan Li, Manmei Li, Lijun Hu, Shuqin Wang, Jian Hong, Wencai Ye, Heru Chen, Ying Wang, Wei Tang
Publikováno v:
mBio, Vol 15, Iss 9 (2024)
ABSTRACT Infection with respiratory syncytial virus (RSV) is a major cause of acute lower respiratory tract disease in young children and older people. Despite intensive efforts over the past few decades, no direct-acting small-molecule agents agains
Externí odkaz:
https://doaj.org/article/6a579b034b354320b9636abfc352a731
Publikováno v:
European journal of medicinal chemistry. 211
Seven tacrine/CHR21 conjugates have been designed and synthesized. Compound 8-7 was confirmed as the most active AChE inhibitor with IC50 value of 5.8 ± 1.4 nM, which was 7.72-fold stronger than tacrine. It was also shown as a strong BuChE inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da55acdff25916181eacf5fa51133181
https://pubmed.ncbi.nlm.nih.gov/33338868
https://pubmed.ncbi.nlm.nih.gov/33338868
Publikováno v:
Bioorganic Chemistry. 110:104769
Three hybrids of dihydro-artemisinin (DHA) with β-aminopropionic acid, γ-aminobutyric acid, and histamine have been designed and synthesized. The conjugate of DHA with GABA labelled as 5b was confirmed the most active candidate against both Cort- a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0977ad66abaa92930f19755b8245dfc8
https://doi.org/10.1016/j.bioorg.2021.104769
https://doi.org/10.1016/j.bioorg.2021.104769