Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Shutish C. Patel"'
Autor:
Shutish C. Patel, Ujendra Kumar
Publikováno v:
Brain Research. 1131:187-196
Among the neurotransmitter abnormalities that have been investigated in Alzheimer's disease (AD), deficits in the cholinergic system have been the most intensively studied. Another key neurotransmitter system involved with emotion and cognition is th
Autor:
Michelle G. de Silva, Tuomas Klockars, Shutish C. Patel, Hans Henrik M. Dahl, Michael S. Hildebrand, Keiko Hirose, C. Arturo Solares, Jonathan D. Smith
Publikováno v:
Hearing Research. 200:102-114
The cochlear portion of the inner ear converts movements produced by sound waves into electrical impulses. Transcripts enriched in the cochlea are likely to have an important role in hearing. In this paper, we report that microarray analyses of the S
Publikováno v:
Journal of Hypertension. 21:199-207
OBJECTIVE To compare the expression and cellular distribution of D(2)-like dopamine receptors in the kidney of the spontaneously hypertensive rat (SHR) and normotensive Wistar-Kyoto (WKY) rat. DESIGN Renal D(2)-like receptor protein expression and di
Publikováno v:
Journal of Neurochemistry. 70:242-251
Apolipoprotein D (apoD), a member of the lipocalin superfamily of ligand transporters, has been implicated in the transport of several small hydrophobic molecules including sterols and steroid hormones. We have previously established that apoD is a s
Publikováno v:
Journal of Neurocytology. 31:121-129
Enhanced apoD gene expression and abnormally high levels of apoD protein accumulation in the brain have been previously documented as features of the neurodegenerative disorder, Niemann-Pick Type C disease (NP-C). In the present study we have used im
Publikováno v:
Journal of Neurocytology. 30:209-218
Apolipoprotein D, a lipocalin transporter of small hydrophobic molecules including sterols, steroid hormones and arachidonic acid, is a widely expressed protein in peripheral and neural tissues. It has been shown to be upregulated in the context of n
Publikováno v:
Journal of Neurocytology. 29:765-773
NPC1 is a member of a family of polytopic membrane-bound proteins with sterol-sensing domains. Inactivating mutations of NPC1 are responsible for most cases of Niemann-Pick type C disease, whose hallmark is progressive neurodegeneration. The precise
Autor:
John P. Incardona, Adele Cooney, Roscoe O. Brady, Eugene D. Carstea, Calvin F. Roff, Nancy K. Dwyer, E. Joan Blanchette-Mackie, Marc C. Patterson, Peter G. Pentchev, Edward B. Neufeld, Jerome F. Strauss, Kousaku Ohno, Sundar Suresh, Shutish C. Patel, Marie T. Vanier, Meryl E. Wastney, Jill A. Morris
Publikováno v:
Journal of Biological Chemistry. 274:9627-9635
Niemann-Pick C disease (NP-C) is a neurovisceral lysosomal storage disorder. A variety of studies have highlighted defective sterol trafficking from lysosomes in NP-C cells. However, the heterogeneous nature of additional accumulating metabolites sug
Autor:
Edward B. Neufeld, Peter G. Pentchev, S Suresh, Ramesh C. Patel, Wei-Yi Ong, C. Y. Hu, Roscoe O. Brady, Yogesh C. Patel, Adele Cooney, E J Blanchette-Mackie, Shutish C. Patel, Ujendra Kumar
Publikováno v:
Proceedings of the National Academy of Sciences. 96:1657-1662
Niemann–Pick type C disease (NP-C) is an inherited neurovisceral lipid storage disorder characterized by progressive neurodegeneration. Most cases of NP-C result from inactivating mutations of NPC1 , a recently identified member of a family of gene
Autor:
E. Joan Blanchette-Mackie, Roscoe O. Brady, Nancy K. Dwyer, Jerome F. Strauss, Shutish C. Patel, Edward B. Neufeld, Hidemichi Watari, Jane M. Glick, Peter G. Pentchev
Publikováno v:
Proceedings of the National Academy of Sciences. 96:805-810
Niemann-Pick type C (NPC) disease is an inherited lipid storage disorder that affects the viscera and central nervous system. A characteristic feature of NPC cells is the lysosomal accumulation of low density lipoprotein-derived cholesterol. To eluci