Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Shutao Guo"'
Publikováno v:
Chem & Bio Engineering, Vol 1, Iss 9, Pp 757-772 (2024)
Externí odkaz:
https://doaj.org/article/fee416d0c04f4d20a1a9e7a5227feaab
Publikováno v:
APL Bioengineering, Vol 6, Iss 4, Pp 046101-046101-11 (2022)
Corticosteroids have for some time been used as first-line drugs for the topical treatment of noninfectious uveitis, but poor ocular bioavailability and the rapid clearance of eye drops necessitate frequent dosing, reducing patient compliance. In thi
Externí odkaz:
https://doaj.org/article/b2c4a0b27b6c4168a2e7487cd83c3a5f
Autor:
Na Yu, Yang Xu, Tao Liu, Haiping Zhong, Zunkai Xu, Tianjiao Ji, Hui Zou, Jingqing Mu, Ziqi Chen, Xing-Jie Liang, Linqi Shi, Daniel S. Kohane, Shutao Guo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Isopropenyl ethers (IPPEs) are essential intermediates for obtaining ketal-based prodrugs and biomaterials, but traditional approaches for their synthesis are limited by poor functional group compatibility and harsh reaction conditions. Here, the aut
Externí odkaz:
https://doaj.org/article/d8349ea0e4a54f0288059ddac35d6da1
Autor:
Yang Xu, Ziqi Chen, Zunkai Xu, Yanyan Du, Jianghao Han, Xiaoyong Yuan, Shubiao Zhang, Shutao Guo
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 16, Iss 2, Pp 213-221 (2021)
Despite advances in treatment of chronic arthritis, there is still a strong need for the development of long-acting formulations that can enable local and sustained drug release at the inflamed tissues. In this work, we fabricated microcrystals of an
Externí odkaz:
https://doaj.org/article/fe72c5d569ff418b9d23cafa24ddaa3a
Autor:
Zunkai Xu, Qingnan Wang, Haiping Zhong, Yaoyao Jiang, Xiaoguang Shi, Bo Yuan, Na Yu, Shubiao Zhang, Xiaoyong Yuan, Shutao Guo, Yang Yang
Publikováno v:
Exploration, Vol 2, Iss 2, Pp n/a-n/a (2022)
Abstract Emerging clustered regularly interspaced short palindromic repeat/associated protein (CRISPR/Cas) genome editing technology shows great potential in gene therapy. However, proteins and nucleic acids suffer from enzymatic degradation in the p
Externí odkaz:
https://doaj.org/article/455d42c5031f4b5a8c0971f68c95799a
Autor:
Yinan Zhao, Tianyi Zhao, Yanyan Du, Yingnan Cao, Yang Xuan, Huiying Chen, Defu Zhi, Shutao Guo, Fangli Zhong, Shubiao Zhang
Publikováno v:
Journal of Nanobiotechnology, Vol 18, Iss 1, Pp 1-14 (2020)
Abstract Background During the course of gene transfection, the interaction kinetics between liposomes and DNA is speculated to play very important role for blood stability, cellular uptake, DNA release and finally transfection efficiency. Results As
Externí odkaz:
https://doaj.org/article/51e7a0c839204eed81231c22ad664d70
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
The anti-diabetic drug Metformin also possesses anti-tumour activity. Here, the authors synthesize polymeric Metformin-based nanoparticles that still exert intrinsic biological activity through AMPK and mTOR regulation and can systematically deliver
Externí odkaz:
https://doaj.org/article/d8d0188e952a4aed809eebe69a78701e
Autor:
Haiping Zhong, Xingwei Li, Na Yu, Xi Zhang, Jingqing Mu, Tao Liu, Bo Yuan, Xiaoyong Yuan, Shutao Guo
Publikováno v:
Chemical Science. 14:3789-3799
Nanoformulated mutual prodrugs able to release two drugs either in order or simultaneously which significantly affected the combination effects consistently in vitro and in vivo, and links the in vitro–in vivo optimization of therapeutic effects.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5c837b11690edbbcee4c6fca4978fda
https://doi.org/10.1039/d3sc00550j
https://doi.org/10.1039/d3sc00550j
Autor:
Na Yu, Xi Zhang, Haiping Zhong, Jingqing Mu, Xingwei Li, Tao Liu, Xiaoguang Shi, Xing-Jie Liang, Shutao Guo
Publikováno v:
Nano Letters. 22:8744-8754
The desmoplastic stroma imposes a fatal physical delivery barrier in pancreatic ductal adenocarcinoma (PDAC) therapy. Deconstructing the stroma components hence predominates in stroma-targeting approaches, but conflicting outcomes have sometimes occu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05e94ec49d249ceb286b185dcb3aef4
https://doi.org/10.1021/acs.nanolett.2c03663
https://doi.org/10.1021/acs.nanolett.2c03663
Autor:
Yi-Feng Wang, Yaxin Zhou, JiaBei Sun, Xiaotong Wang, Yaru Jia, Kun Ge, Yan Yan, Kenneth A. Dawson, Shutao Guo, Jinchao Zhang, Xing-Jie Liang
Publikováno v:
Nano Research. 16:715-734
Nanoparticles-based drug delivery systems have attracted significant attention in biomedical fields because they can deliver loaded cargoes to the target site in a controlled manner. However, tremendous challenges must still be overcome to reach the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4bdcd623245f78fbfeeee406fc12d83
https://doi.org/10.1007/s12274-022-4849-6
https://doi.org/10.1007/s12274-022-4849-6