Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Shuren Liao"'
Autor:
Pietro Mancuso, Chen Chen, Rafal Kaminski, Jennifer Gordon, Shuren Liao, Jake A. Robinson, Mandy D. Smith, Hong Liu, Ilker K. Sariyer, Rahsan Sariyer, Tiffany A. Peterson, Martina Donadoni, Jaclyn B. Williams, Summer Siddiqui, Bruce A. Bunnell, Binhua Ling, Andrew G. MacLean, Tricia H. Burdo, Kamel Khalili
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Removal of integrated HIV DNA remains a roadblock for HIV cure. Here, Mancuso et al. show that intravenous administration of an adeno-associated virus-based CRISPR/Cas9 gene editing construct to SIV-infected macaques results in excision of integrated
Externí odkaz:
https://doaj.org/article/8cbe71bbcb2e47d19d5219446802dbe4
Autor:
Gurushankar Chandramouly, Shuren Liao, Timur Rusanov, Nikita Borisonnik, Marissa L. Calbert, Tatiana Kent, Katherine Sullivan-Reed, Umeshkumar Vekariya, Ekaterina Kashkina, Tomasz Skorski, Hong Yan, Richard T. Pomerantz
Publikováno v:
Cell Reports, Vol 34, Iss 10, Pp 108820- (2021)
Summary: DNA polymerase θ (Polθ) confers resistance to chemotherapy agents that cause DNA-protein crosslinks (DPCs) at double-strand breaks (DSBs), such as topoisomerase inhibitors. This suggests Polθ might facilitate DPC repair by microhomology-m
Externí odkaz:
https://doaj.org/article/032b802c5b494e9997a34a69d6f7c32a
Autor:
Martina Donadoni, Rafal Kaminski, Shuren Liao, Suhair Al Janabi, Robert F. Margolskee, Mehmet Hakan Ozdener, Ilker K. Sariyer
Publikováno v:
Journal of NeuroVirology. 29:35-44
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cdcdb755de0a66e478a4b798d3de06a
https://doi.org/10.1007/s13365-023-01117-3
https://doi.org/10.1007/s13365-023-01117-3
Autor:
Prasanta K. Dash, Chen Chen, Rafal Kaminski, Hang Su, Pietro Mancuso, Brady Sillman, Chen Zhang, Shuren Liao, Sruthi Sravanam, Hong Liu, Emiko Waight, Lili Guo, Saumi Mathews, Rahsan Sariyer, R. Lee Mosley, Larisa Y. Poluektova, Maurizio Caocci, Shohreh Amini, Santhi Gorantla, Tricia H. Burdo, Benson Edagwa, Howard E. Gendelman, Kamel Khalili
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Treatment of HIV-1 ADA -infected CD34+ NSG-humanized mice with long-acting ester prodrugs of cabotegravir, lamivudine, and abacavir in combination with native rilpivirine was followed by dual CRISPR-Cas9 C-C chemokine receptor type five (CCR5) and HI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0521cb8aacc7a64087afd83a552e4482
https://doi.org/10.1073/pnas.2217887120
https://doi.org/10.1073/pnas.2217887120
Autor:
Dash, Prasanta K., Chen Chen, Kaminski, Rafal, Hang Su, Mancuso, Pietro, Sillman, Brady, Chen Zhang, Shuren Liao, Sravanam, Sruthi, Hong Liu, Waight, Emiko, Lili Guo, Mathews, Saumi, Sariyer, Rahsan, Mosley, R. Lee, Poluektova, Larisa Y., Caocci, Maurizio, Amini, Shohreh, Gorantla, Santhi, Burdo, Tricia H.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 5/9/2023, Vol. 120 Issue 19, p1-10, 35p
Autor:
Kamel Khalili, Mandy D. Smith, Rahsan Sariyer, Pietro Mancuso, Jennifer Gordon, Bruce A. Bunnell, Hong Liu, Rafal Kaminski, Tricia H. Burdo, Ilker Kudret Sariyer, Jake A. Robinson, Tiffany A. Peterson, Andrew G. MacLean, Martina Donadoni, Binhua Ling, Summer Siddiqui, Shuren Liao, Chen Chen, Jaclyn B. Williams
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
Elimination of HIV DNA from infected individuals remains a challenge in medicine. Here, we demonstrate that intravenous inoculation of SIV-infected macaques, a well-accepted non-human primate model of HIV infection, with adeno-associated virus 9 (AAV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bff0bd71330bda63430b939d74e604d9
https://doi.org/10.1038/s41467-020-19821-7
https://doi.org/10.1038/s41467-020-19821-7
Autor:
Timur Rusanov, Tatiana Kent, Ekaterina Kashkina, Gurushankar Chandramouly, Tomasz Skorski, Marissa L. Calbert, Shuren Liao, Katherine Sullivan-Reed, Hong Yan, Nikita Borisonnik, Richard T. Pomerantz, Umeshkumar Vekariya
Publikováno v:
Cell reports
Cell Reports, Vol 34, Iss 10, Pp 108820-(2021)
Cell Reports, Vol 34, Iss 10, Pp 108820-(2021)
SUMMARY DNA polymerase θ (Polθ) confers resistance to chemotherapy agents that cause DNA-protein crosslinks (DPCs) at double-strand breaks (DSBs), such as topoisomerase inhibitors. This suggests Polθ might facilitate DPC repair by microhomology-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ff5829c00e26a6a5bf957ed3a990200
https://doi.org/10.1016/j.celrep.2021.108820
https://doi.org/10.1016/j.celrep.2021.108820
Publikováno v:
Nucleic Acids Research
The key event in the choice of repair pathways for DNA double-strand breaks (DSBs) is the initial processing of ends. Non-homologous end joining (NHEJ) involves limited processing, but homology-dependent repair (HDR) requires extensive resection of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3da3c23a8dd678bba9fc63c1a87a73
https://doi.org/10.1093/nar/gkw274
https://doi.org/10.1093/nar/gkw274
Publikováno v:
Nucleic Acids Research
The first step of homology-dependent repair of DNA double-strand breaks (DSBs) is the resection of the 5′ strand to generate 3′ ss-DNA. Of the two major nucleases responsible for resection, EXO1 has intrinsic 5′->3′ directionality, but DNA2 d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc90d98ed9ab65d5a18a4d8c8398fece
https://doi.org/10.1093/nar/gkv764
https://doi.org/10.1093/nar/gkv764
Publikováno v:
Genes
Genes, Vol 7, Iss 7, p 32 (2016)
Genes, Vol 7, Iss 7, p 32 (2016)
Topoisomerase 2 (Top2) is an essential enzyme responsible for manipulating DNA topology during replication, transcription, chromosome organization and chromosome segregation. It acts by nicking both strands of DNA and then passes another DNA molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25af95eb49efbf333433ce1eaea9e76b
https://pubmed.ncbi.nlm.nih.gov/27376333
https://pubmed.ncbi.nlm.nih.gov/27376333