Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Shuqiu Zheng"'
Autor:
Diane L. Rosin, J. Perry Hall, Shuqiu Zheng, Liping Huang, Silvia Campos-Bilderback, Ruben Sandoval, Andrea Bree, Kevin Beaumont, Emily Miller, Jennifer Larsen, Ghazal Hariri, Neelu Kaila, Iain M. Encarnacion, Jeremy D. Gale, Andrea van Elsas, Bruce A. Molitoris, Mark D. Okusa
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Adenosine triphosphate (ATP) released from injured or dying cells is a potent pro-inflammatory “danger” signal. Alkaline phosphatase (AP), an endogenous enzyme that de-phosphorylates extracellular ATP, likely plays an anti-inflammatory role in im
Externí odkaz:
https://doaj.org/article/8a48422a8c3f4fea9d0b25430207d3fe
Autor:
Shuqiu Zheng, Erin B D Clabough, Sovan Sarkar, Marie Futter, David C Rubinsztein, Scott O Zeitlin
Publikováno v:
PLoS Genetics, Vol 6, Iss 2, p e1000838 (2010)
Expansion of a stretch of polyglutamine in huntingtin (htt), the protein product of the IT15 gene, causes Huntington's disease (HD). Previous investigations into the role of the polyglutamine stretch (polyQ) in htt function have suggested that its le
Externí odkaz:
https://doaj.org/article/2d361b37d097434f887a4dccdad06df9
Autor:
Shinji Tanaka, Shuqiu Zheng, Yugesh Kharel, Russell G. Fritzemeier, Tao Huang, Daniel Foster, Nabin Poudel, Eibhlin Goggins, Yusuke Yamaoka, Kinga P. Rudnicka, Jonathan E. Lipsey, Hope V. Radel, Sophia M. Ryuh, Tsuyoshi Inoue, Junlan Yao, Diane L. Rosin, Susan R. Schwab, Webster L. Santos, Kevin R. Lynch, Mark D. Okusa
Publikováno v:
Science Translational Medicine. 14
Chronic kidney disease (CKD), characterized by sustained inflammation and progressive fibrosis, is highly prevalent and can eventually progress to end-stage kidney disease. However, current treatments to slow CKD progression are limited. Sphingosine
Autor:
Tsuyoshi Inoue, Liping Huang, Hong Ye, Shuqiu Zheng, Junlan Yao, Diane L. Rosin, Takahide Kohro, Mark D. Okusa, Youichiro Wada, Ruth L. Stornetta, Masaomi Nangaku, Shinji Tanaka, Chikara Abe, Reiko Inagi
Publikováno v:
Kidney Int
The cholinergic anti-inflammatory pathway (CAP) links the nervous and immune systems and modulates innate and adaptive immunity. Activation of the CAP by vagus nerve stimulation exerts protective effects in a wide variety of clinical disorders includ
Autor:
Stephen B. G. Abbott, Chikara Abe, Shuqiu Zheng, Shinji Tanaka, Ruth L. Stornetta, Junlan Yao, Nataliya I. Skrypnyk, Tsuyoshi Inoue, Jonathan E Lipsey, Patrice G. Guyenet, Mark D. Okusa, Yusuke Yamaoka, Daniel S. Stornetta, William T. Nash, Diane L. Rosin
Publikováno v:
Proc Natl Acad Sci U S A
Acute kidney injury is highly prevalent and associated with high morbidity and mortality, and there are no approved drugs for its prevention and treatment. Vagus nerve stimulation (VNS) alleviates inflammatory diseases including kidney disease; howev
Autor:
Diane L. Rosin, Nabin Poudel, Heather M. Perry, Shuqiu Zheng, Rui Cao, Mark D. Okusa, Song Hu, Naidi Sun, Junlan Yao
Publikováno v:
Kidney international. 100(3)
Microcirculatory changes and oxidative stress have long been associated with acute kidney injury. Despite substantial progress made by two-photon microscopy of microvascular responses to acute kidney injury in rodent models, little is known about the
Publikováno v:
Nephron
Understanding and measuring parameters responsible for the pathogenesis of sepsis-induced AKI (SI-AKI) is critical in developing therapies. Blood flow to the kidney is heterogeneous, partly due to the existence of dynamic networks of capillaries in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dff90cc0ec697e3b67614faa110f5f8f
https://europepmc.org/articles/PMC7935434/
https://europepmc.org/articles/PMC7935434/
Autor:
Fanzhen Kong, Jonathan Kipnis, Rolf Skyberg, Jianhua C. Cang, Chengsan Sun, Geoffrey T. Norris, Alev Erisir, Mei Cheng, Justin S. A. Perry, David L. Hill, Shuqiu Zheng
Publikováno v:
SSRN Electronic Journal.
A key process in central sensory circuit development involves activity-dependent “pruning” of early exuberant terminals. Here, we studied gustatory terminal field maturation in the postnatal mouse nucleus of the solitary tract (NST) during normal
Autor:
Tanaka, Shinji, Abe, Chikara, Abbott, Stephen B. G., Shuqiu Zheng, Yusuke Yamaoka, Lipsey, Jonathan E., Skrypnyk, Nataliya I., Junlan Yao, Tsuyoshi Inoue, Nash, William T., Stornetta, Daniel S., Rosin, Diane L., Stornetta, Ruth L., Guyenet, Patrice G., Okusa, Mark D.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 3/23/2021, Vol. 118 Issue 12, p1-12, 12p
Autor:
Sandrine Humbert, Daniel J. Klionsky, Kai Mao, Julia Margulis, Joan S. Steffan, Steven Finkbeiner, Joseph Ochaba, Alice L. Lau, Shuqiu Zheng, Lisa Salazar, Tamas Lukacsovich, George Csikos, Frédéric Saudou, Scott Zeitlin, Sylvia Y. Yeung, J. Lawrence Marsh, Leslie M. Thompson, David E. Housman
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 111, iss 47
Ochaba, J; Lukacsovich, T; Csikos, G; Zheng, S; Margulis, J; Salazar, L; et al.(2014). Potential function for the Huntingtin protein as a scaffold for selective autophagy. Proceedings of the National Academy of Sciences of the United States of America, 111(47), 16889-16894. doi: 10.1073/pnas.1420103111. UCSF: Retrieved from: http://www.escholarship.org/uc/item/33x3781x
Ochaba, J; Lukacsovich, T; Csikos, G; Zheng, S; Margulis, J; Salazar, L; et al.(2014). Potential function for the Huntingtin protein as a scaffold for selective autophagy. Proceedings of the National Academy of Sciences of the United States of America, 111(47), 16889-16894. doi: 10.1073/pnas.1420103111. UCSF: Retrieved from: http://www.escholarship.org/uc/item/33x3781x
Although dominant gain-of-function triplet repeat expansions in the Huntingtin (HTT) gene are the underlying cause of Huntington disease (HD), understanding the normal functions of nonmutant HTT protein has remained a challenge. We report here findin