Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Shuo-Xing Dou"'
Autor:
Ying Xiong, Weijing Han, Chunhua Xu, Jing Shi, Lisha Wang, Taoli Jin, Qi Jia, Ying Lu, Shuxin Hu, Shuo-Xing Dou, Wei Lin, Terence R. Strick, Shuang Wang, Ming Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Factor-dependent termination uses molecular motors to remodel transcription machineries, but the associated mechanisms, especially in eukaryotes, are poorly understood. Here we use single-molecule fluorescence assays to characterize in real
Externí odkaz:
https://doaj.org/article/549b4163dce149ccbd7292ceb63600fe
Autor:
Chao Jiang, Hong-Yu Luo, Xinpeng Xu, Shuo-Xing Dou, Wei Li, Dongshi Guan, Fangfu Ye, Xiaosong Chen, Ming Guo, Peng-Ye Wang, Hui Li
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Cell migration plays important roles in many biological processes, but how migrating cells orchestrate intracellular molecules and subcellular structures to regulate their speed and direction is still not clear. Here, by characterizing the i
Externí odkaz:
https://doaj.org/article/f75cd0760c1a47b0a47803134da555d7
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101790- (2022)
Summary: Intracellular transport plays an important role in maintaining the physiological functions of cells. Here, we describe a protocol for 3D single-particle tracking within living cells. We detail the use of a two-focal imaging system and the an
Externí odkaz:
https://doaj.org/article/cc234c55e2d4455da53bc35bc6627faa
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104210- (2022)
Summary: Intracellular transport, regulated by complex cytoarchitectures and active driving forces, is crucial for biomolecule translocations and relates to many cellular functions. Despite extensive knowledge obtained from two-dimensional (2D) exper
Externí odkaz:
https://doaj.org/article/be3a53e8c40f42af9e50faa936d653a2
Autor:
Hai-Peng Ju, Yi-Zhou Wang, Jing You, Xi-Miao Hou, Xu-Guang Xi, Shuo-Xing Dou, Wei Li, Peng-Ye Wang
Publikováno v:
ACS Omega, Vol 1, Iss 2, Pp 244-250 (2016)
Externí odkaz:
https://doaj.org/article/29aa1b5be7f0434cb3dc8edb812067d4
Autor:
Hong-Yan Zhang, Yu-Ru Liu, Wei Li, Hui Li, Shuo-Xing Dou, Ping Xie, Wei-Chi Wang, Peng-Ye Wang
Publikováno v:
AIP Advances, Vol 4, Iss 8, Pp 087128-087128-8 (2014)
Heptaplatin is a third-generation platinum antitumor drug. It has a chiral isomer. We studied the interactions between the two isomers and DNA by using magnetic tweezers and atomic force microscopy (AFM) to investigate the effect of chiralities of th
Externí odkaz:
https://doaj.org/article/e87ff017b2794ba08a773f5e0667b542
Autor:
Hong-Yan Zhang, Yu-Ru Liu, Chao Ji, Wei Li, Shuo-Xing Dou, Ping Xie, Wei-Chi Wang, Ling-Yun Zhang, Peng-Ye Wang
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71556 (2013)
The interactions of DNA with oxaliplatin (Pt(R,R-DACH)) or its enantiomer (Pt(S,S-DACH)) were investigated using magnetic tweezers and atomic force microscope. In the process of DNA condensation induced by Pt-DACH, only diadducts and micro-loops are
Externí odkaz:
https://doaj.org/article/9f74b433802646b49784614aae52a849
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45465 (2012)
Paclitaxel (PTX), a chemotherapeutic drug, affects microtubule dynamics and influences endocytic trafficking. However, the mechanism and the dynamics of altered endocytic trafficking by paclitaxel treatment in single living cells still remain elusive
Externí odkaz:
https://doaj.org/article/6870a3bd3a554174a825b265d51a766f
Publikováno v:
Chinese Physics Letters.
G-quadruplex (G4) is one of the higher-order DNA structures in guanine-rich sequences which are widely distributed across the genome. Due to their presence in oncogenic promoters and telomeres, G4 DNA structures become the novel targets in anticancer
Autor:
Yi-Zhou Wang, Wei Li, Ming Li, Xue Xiao, Yinuo Liu, Shuo-Xing Dou, Jingwei Kong, Ping Chen, Anfeng Luo, Ke Lu, Lu Ma, Jun Chen, Guohong Li, Peng-Ye Wang, Shuming Zhang, Cuifang Liu, Zhichao Lei
Publikováno v:
Biochemistry. 60:494-499
The candidate anticancer drug curaxins can insert into DNA base pairs and efficiently inhibit the growth of various cancers. However, how curaxins alter the genomic DNA structure and affect the DNA binding property of key proteins remains to be clari