Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Shunxing Rong"'
Autor:
Zhao Zhang, Yu Xun, Shunxing Rong, Lijuan Yan, Jeffrey A. SoRelle, Xiaohong Li, Miao Tang, Katie Keller, Sara Ludwig, Eva Marie Y. Moresco, Bruce Beutler
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Obesity is a major risk factor for fatty liver disease. Here, using a forward genetic screen, the authors identify the gene GM4951 as a GTPase involved in lipid oxidation and development of NAFLD in mice.
Externí odkaz:
https://doaj.org/article/0fb5045a02d548e7bf3ceeaa615047a3
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100031- (2021)
Abstract: Genetic variants that increase the risk of fatty liver disease and cirrhosis have recently been identified in the proximity of membrane-bound O-acyltransferase domain-containing 7 (MBOAT7). To elucidate the link between these variants and f
Externí odkaz:
https://doaj.org/article/db253cd6b62f41b0ac153e0f29fb108e
Cholesterol auxotrophy and intolerance to ezetimibe in mice with SREBP-2 deficiency in the intestine
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 10, Pp 1988-1998 (2017)
SREBP-2 activates transcription of all genes needed for cholesterol biosynthesis. To study SREBP-2 function in the intestine, we generated a mouse model (Vil-BP2−/−) in which Cre recombinase ablates SREBP-2 in intestinal epithelia. Intestines of
Externí odkaz:
https://doaj.org/article/4d29a3d8c88d4be09361173ebe9f2d4a
CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL
Autor:
Paulina Bartuzi, Daniel D. Billadeau, Robert Favier, Shunxing Rong, Daphne Dekker, Alina Fedoseienko, Hille Fieten, Melinde Wijers, Johannes H. Levels, Nicolette Huijkman, Niels Kloosterhuis, Henk van der Molen, Gemma Brufau, Albert K. Groen, Alison M. Elliott, Jan Albert Kuivenhoven, Barbara Plecko, Gernot Grangl, Julie McGaughran, Jay D. Horton, Ezra Burstein, Marten H. Hofker, Bart van de Sluis
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Low density lipoprotein receptor (LDLR) is crucial for cholesterol homeostasis. Here, the authors show that components of the CCC-protein complex, CCDC22 and COMMD1, facilitate the endosomal sorting of LDLR and that mutations in these genes cause hyp
Externí odkaz:
https://doaj.org/article/8e60ef48969c43c189785a273159992f
Autor:
Shunxing Rong, Víctor A Cortés, Shirya Rashid, Norma N Anderson, Jeffrey G McDonald, Guosheng Liang, Young-Ah Moon, Robert E Hammer, Jay D Horton
Publikováno v:
eLife, Vol 6 (2017)
The synthesis of cholesterol and fatty acids (FA) in the liver is independently regulated by SREBP-2 and SREBP-1c, respectively. Here, we genetically deleted Srebf-2 from hepatocytes and confirmed that SREBP-2 regulates all genes involved in choleste
Externí odkaz:
https://doaj.org/article/7a399467622743c8aff8f96e1e76e2be
Autor:
Víctor A. Cortés, Kelly M. Cautivo, Shunxing Rong, Abhimanyu Garg, Jay D. Horton, Anil K. Agarwal
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 2, Pp 276-288 (2014)
Leptin is essential for energy homeostasis and regulation of food intake. Patients with congenital generalized lipodystrophy (CGL) due to mutations in 1-acylglycerol-3-phosphate-O-acyltransferase 2 (AGPAT2) and the CGL murine model (Agpat2−/− mic
Externí odkaz:
https://doaj.org/article/01deecd765a8409e813e92cd41137ed9
Autor:
Shunxing Rong, Qiang Cao, Mingxia Liu, Jeongmin Seo, Lin Jia, Elena Boudyguina, Abraham K. Gebre, Perry L. Colvin, Thomas L. Smith, Robert C. Murphy, Nilamadhab Mishra, John S. Parks
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 4, Pp 686-695 (2012)
12/15 lipoxygenase (12/15LO) oxidizes polyunsaturated fatty acids (PUFAs) to form bioactive lipid mediators. The role of 12/15LO in atherosclerosis development remains controversial. We evaluated atherosclerosis development and lipid metabolism in 12
Externí odkaz:
https://doaj.org/article/e01e069bb0fa4b40be7d94acf82a9726
Autor:
Lin Jia, Yinyan Ma, Shunxing Rong, Jenna L. Betters, Ping Xie, Soonkyu Chung, Nanping Wang, Weiqing Tang, Liqing Yu
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 11, Pp 3135-3144 (2010)
Niemann-Pick C1-Like 1 (NPC1L1) mediates intestinal absorption of dietary and biliary cholesterol. Ezetimibe, by inhibiting NPC1L1 function, is widely used to treat hypercholesterolemia in humans. Interestingly, ezetimibe treatment appears to attenua
Externí odkaz:
https://doaj.org/article/a69c908d5d254de2aee222581724fc82
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 4, Pp 849-855 (2010)
The plasmid vector pLIV11 is used commonly to achieve liver-specific expression of genes of interest in transgenic mice and rabbits. Expression is driven by the human apolipoprotein (apo)E 5′ proximal promoter, which includes 5 kb of upstream seque
Externí odkaz:
https://doaj.org/article/2019c8fffe844abd8bd3a1fdcb7ff864
Autor:
Hui Ma, Xiaopeng Zhu, Linshan Zhang, Mingfeng Xia, Xinxia Chang, Jian Gao, Baishen Pan, Xiaoyang Sun, Hongmei Yan, Li Wu, Huandong Lin, Wanyuan He, Xiqi Hu, Shunxing Rong, Yu Hu, Hailuan Zeng, Xin Gao, Hua Bian, Xiaoming Li, Lingyan Chen
Publikováno v:
Journal of Bone and Mineral Research. 36:712-728
Osteocalcin regulates energy metabolism in an active undercarboxylated/uncarboxylated form. However, its role on the development of non-alcoholic fatty liver disease (NAFLD) is still controversial. In the current study, we investigated the causal rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6140706c21d42d5f2c588fc1c615b19
https://doi.org/10.1002/jbmr.4227
https://doi.org/10.1002/jbmr.4227