Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Shuntaro Takahashi"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Ligands that recognise specific i-motif DNAs are helpful in cancer diagnostics and therapeutics, as i-motif formation can cause cancer. Although the loop regions of i-motifs are promising targets for ligands, the interaction between a ligand
Externí odkaz:
https://doaj.org/article/965bb7cdba39409e935bae8f8433317d
Autor:
Takao Hoshino, Takafumi Mizuno, Kentaro Ishizuka, Shuntaro Takahashi, Satoko Arai, Sono Toi, Kazuo Kitagawa
Publikováno v:
Cardiovascular Diabetology, Vol 21, Iss 1, Pp 1-9 (2022)
Abstract Background Triglyceride-glucose (TyG) index has been proposed as a simple and credible surrogate for insulin resistance and an independent predictor of cardiovascular outcomes. Due to lack of data on TyG index in stroke, we aimed to evaluate
Externí odkaz:
https://doaj.org/article/f0b5f0507b8e4449aa28391ca6b2c012
Autor:
Shuntaro Takahashi, Saki Matsumoto, Pallavi Chilka, Saptarshi Ghosh, Hiromichi Okura, Naoki Sugimoto
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract In biological systems, the synthesis of nucleic acids, such as DNA and RNA, is catalyzed by enzymes in various aqueous solutions. However, substrate specificity is derived from the chemical properties of the residues, which implies that pert
Externí odkaz:
https://doaj.org/article/1429a0e127024b148ceba374a260dfc1
Publikováno v:
ACS Omega, Vol 4, Iss 2, Pp 4325-4329 (2019)
Externí odkaz:
https://doaj.org/article/a202e58a3f9e411cba70620386d1a311
Publikováno v:
Life, Vol 12, Iss 4, p 553 (2022)
The human telomere region is known to contain guanine-rich repeats and form a guanine-quadruplex (G4) structure. As telomeres play a role in the regulation of cancer progression, ligands that specifically bind and stabilize G4 have potential therapeu
Externí odkaz:
https://doaj.org/article/f510d65bca504f679f670aabd52e8725
Publikováno v:
ACS Omega, Vol 1, Iss 6, Pp 1247-1252 (2016)
Externí odkaz:
https://doaj.org/article/6f8fece47bba4aeead83ae011dddcc97
Publikováno v:
Molecules, Vol 25, Iss 18, p 4120 (2020)
Unnatural nucleic acids are promising materials to expand genetic information beyond the natural bases. During replication, substrate nucleotide incorporation should be strictly controlled for optimal base pairing with template strand bases. Base-pai
Externí odkaz:
https://doaj.org/article/9c24781c9f39409c91d767be613a0b02
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189326 (2017)
The performance of deep learning in natural language processing has been spectacular, but the reasons for this success remain unclear because of the inherent complexity of deep learning. This paper provides empirical evidence of its effectiveness and
Externí odkaz:
https://doaj.org/article/16493689257d4cbb87b8ae7d89205206
Autor:
Shuntaro Takahashi, Naoki Sugimoto
Publikováno v:
Molecules, Vol 18, Iss 11, Pp 13297-13319 (2013)
Pressure is a thermodynamic parameter that can induce structural changes in biomolecules due to a volumetric decrease. Although most proteins are denatured by pressure over 100 MPa because they have the large cavities inside their structures, the dou
Externí odkaz:
https://doaj.org/article/808d0583bfe14045b887c6c44ab74bd5
Autor:
Shuntaro Takahashi, Boris Chelobanov, Ki Tae Kim, Byeang Hyean Kim, Dmitry Stetsenko, Naoki Sugimoto
Publikováno v:
Molecules, Vol 23, Iss 12, p 3228 (2018)
The formation of a guanine quadruplex DNA structure (G4) is known to repress the expression of certain cancer-related genes. Consequently, a mutated G4 sequence can affect quadruplex formation and induce cancer progression. In this study, we develope
Externí odkaz:
https://doaj.org/article/dba394f7eb374ba6a57998c92763b209