Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Shunsuke Yamane"'
Autor:
Akihiro Hamasaki, Norio Harada, Atsushi Muraoka, Shunsuke Yamane, Erina Joo, Kazuyo Suzuki, Nobuya Inagaki
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionIncretin-based drugs are extensively utilized in the treatment of type 2 diabetes (T2D), with remarkable clinical efficacy. These drugs were developed based on findings that the incretin effect is reduced in T2D. The incretin effect in Ea
Externí odkaz:
https://doaj.org/article/8161b599d06c43c2847ed02fe5a9a957
Autor:
Tomonobu Hatoko, Norio Harada, Shinsuke Tokumoto, Shunsuke Yamane, Eri Ikeguchi-Ogura, Tomoko Kato, Takuma Yasuda, Hisato Tatsuoka, Satoko Shimazu-Kuwahara, Daisuke Yabe, Yoshitaka Hayashi, Nobuya Inagaki
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Tissue optical clearing permits detailed evaluation of organ three-dimensional (3-D) structure as well as that of individual cells by tissue staining and autofluorescence. In this study, we evaluated intestinal morphology, intestinal epithel
Externí odkaz:
https://doaj.org/article/444c2be1c89a4867a8b89ba4bb7497c6
Autor:
Sakura Kiyobayashi, Takaaki Murakami, Norio Harada, Hiroyuki Fujimoto, Yuki Murata, Naotaka Fujita, Keita Hamamatsu, Eri Ikeguchi-Ogura, Tomonobu Hatoko, Xuejing Lu, Shunsuke Yamane, Nobuya Inagaki
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Pancreatic β-cell mass (BCM) has an importance in the pathophysiology of diabetes mellitus. Recently, glucagon-like peptide-1 receptor (GLP-1R)-targeted imaging has emerged as a promising tool for BCM evaluation. While glucose-dependent insulinotrop
Externí odkaz:
https://doaj.org/article/56eb90921da74ff78c9ad91627258319
Autor:
Yuki Murata, Norio Harada, Shigenobu Kishino, Kanako Iwasaki, Eri Ikeguchi-Ogura, Shunsuke Yamane, Tomoko Kato, Yoshinori Kanemaru, Akiko Sankoda, Tomonobu Hatoko, Sakura Kiyobayashi, Jun Ogawa, Akira Hirasawa, Nobuya Inagaki
Publikováno v:
iScience, Vol 24, Iss 9, Pp 102963- (2021)
Summary: Long-chain triglycerides (LCTs) intake strongly stimulates GIP secretion from enteroendocrine K cells and induces obesity and insulin resistance partly due to GIP hypersecretion. In this study, we found that medium-chain triglycerides (MCTs)
Externí odkaz:
https://doaj.org/article/2164c584dab04609a57a748fcf6b2b5e
Autor:
Akiko Sankoda, Norio Harada, Tomoko Kato, Eri Ikeguchi, Kanako Iwasaki, Shunsuke Yamane, Yuki Murata, Akira Hirasawa, Nobuya Inagaki
Publikováno v:
Journal of Diabetes Investigation, Vol 10, Iss 6, Pp 1430-1437 (2019)
Abstract Aims/Introduction Incretin hormone glucose‐dependent insulinotropic polypeptide/gastric inhibitory polypeptide (GIP) plays a key role in high‐fat diet‐induced obesity and insulin resistance. GIP is strongly secreted from enteroendocrin
Externí odkaz:
https://doaj.org/article/83075307947f4fc08ffd7c36068a33d5
Autor:
Satoko Shimazu‐Kuwahara, Yoshinori Kanemaru, Norio Harada, Eri Ikeguchi, Yohei Ueda, Shunsuke Yamane, Yuki Murata, Akihiro Yasoda, Timothy J Kieffer, Nobuya Inagaki
Publikováno v:
Journal of Diabetes Investigation, Vol 10, Iss 4, Pp 909-914 (2019)
Abstract Given the established roles of glucose‐dependent insulinotropic polypeptide (GIP) in promoting fat storage and bone formation, we assessed the contribution of GIP to obesity and osteopenia in ovariectomized mice with a gene encoding green
Externí odkaz:
https://doaj.org/article/656fc3cc51de4cdb87469659c45eee6b
Autor:
Shunsuke Yamane, Norio Harada
Publikováno v:
Journal of Diabetes Investigation, Vol 10, Iss 1, Pp 3-5 (2019)
Externí odkaz:
https://doaj.org/article/6231d096fa5f4193b07a5539d83c3781
Autor:
Satoko Shimazu-Kuwahara, Norio Harada, Shunsuke Yamane, Erina Joo, Akiko Sankoda, Timothy J. Kieffer, Nobuya Inagaki
Publikováno v:
Molecular Metabolism, Vol 6, Iss 3, Pp 288-294 (2017)
Objective: Glucose-dependent insulinotropic polypeptide (GIP) is released during meals and promotes nutrient uptake and storage. GIP receptor knockout mice are protected from diet induced weight gain and thus GIP antagonists have been proposed as a t
Externí odkaz:
https://doaj.org/article/418f425322f44c128f9fc79fa605f63b
Autor:
Jungmi Choi, Hatasu Kobayashi, Hiroko Okuda, Kouji H Harada, Midori Takeda, Hiroyuki Fujimoto, Shunsuke Yamane, Daisuke Tanaka, Shohab Youssefian, Nobuya Inagaki, Akio Koizumi
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190863 (2018)
Adiponectin, a metabolically-active cytokine secreted from adipose tissue, is reported to have anti-apoptotic effects on β-cells as well as anti-hyperglycemic effects through adiponectin receptor signaling. However, the anti-apoptotic effects of adi
Externí odkaz:
https://doaj.org/article/ab958e6f4f134a6eb3399cf6da1616af
Autor:
Takuma Yasuda, Norio Harada, Tomonobu Hatoko, Atsuhiko Ichimura, Eri Ikeguchi-Ogura, Yuki Murata, Naoki Wada, Sakura Kiyobayashi, Shunsuke Yamane, Akira Hirasawa, Nobuya Inagaki
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 324:E449-E460
We generated novel intestine-specific GPR120-knockout ( GPR120int−/−) mice and investigated the metabolic effect of GPR120 in the intestine. GPR120int−/− mice exhibited a reduction of GIP secretion and CCK action after a single administration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1d5fe2921ef333e49f4fa12652ec05a
https://doi.org/10.1152/ajpendo.00329.2022
https://doi.org/10.1152/ajpendo.00329.2022