Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Shunsuke Kubota"'
Autor:
Hiroaki Fujita, Taiichi Wakiya, Yota Tatara, Keinosuke Ishido, Yoshiyuki Sakamoto, Norihisa Kimura, Hajime Morohashi, Takuya Miura, Takahiro Muroya, Harue Akasaka, Hiroshi Yokoyama, Taishu Kanda, Shunsuke Kubota, Aika Ichisawa, Kenta Ogasawara, Daisuke Kuwata, Yoshiya Takahashi, Akie Nakamura, Keisuke Yamazaki, Takahiro Yamada, Ryo Matsuyama, Masanobu Kanou, Kei Yamana, Ken Itoh, Kenichi Hakamada
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Nicotinamide adenine dinucleotide (NAD +) plays a pivotal role in numerous cellular functions. Reduced NAD + levels are postulated to be associated with cancer. As interest in understanding NAD + dynamics in cancer patients with therapeutic
Externí odkaz:
https://doaj.org/article/36e1888fc82c4bf1b7f2105e410b61a2
Autor:
Akiko Hanyuda, Miyuki Kubota, Shunsuke Kubota, Sachiko Masui, Kenya Yuki, Kazuo Tsubota, Kazuno Negishi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Monitoring dynamic changes in near vision is important for early detection of presbyopia. This study assessed the accuracy and reliability of a new smartphone-based application, the Smart Vision Check (SVC), compared with those of a conventi
Externí odkaz:
https://doaj.org/article/26998847903f44b1a2421f6ae5cd5668
Autor:
Hirokazu Ogasawara, Tadashi Yoshizawa, Kiyoko Oshima, Kenta Ogasawara, Shunsuke Kubota, Shintaro Goto, Satoko Morohashi, Taiichi Wakiya, Norihisa Kimura, Keinosuke Ishido, Hiroshi Kijima, Kenichi Hakamada
Publikováno v:
Pathology and Oncology Research, Vol 29 (2023)
Perineural invasion (PNI) is a characteristic invasion pattern of distal cholangiocarcinoma (DCC). Conventional histopathologic examination is a challenging approach to analyze the spatial relationship between cancer and neural tissue in full-thickne
Externí odkaz:
https://doaj.org/article/6fd27a322e8646aaba4baefc26f6ec11
Autor:
Taiichi Wakiya, Keinosuke Ishido, Norihisa Kimura, Hayato Nagase, Taishu Kanda, Sotaro Ichiyama, Kenji Soma, Masashi Matsuzaka, Yoshihiro Sasaki, Shunsuke Kubota, Hiroaki Fujita, Takeyuki Sawano, Yutaka Umehara, Yusuke Wakasa, Yoshikazu Toyoki, Kenichi Hakamada
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Preoperatively accurate evaluation of risk for early postoperative recurrence contributes to maximizing the therapeutic success for intrahepatic cholangiocarcinoma (iCCA) patients. This study aimed to investigate the potential of deep learni
Externí odkaz:
https://doaj.org/article/7d783893feed46d2be672fabc6eced26
Autor:
Takuya Miura, Yoshiyuki Sakamoto, Hajime Morohashi, Akiko Suto, Shunsuke Kubota, Aika Ichisawa, Daisuke Kuwata, Takahiro Yamada, Hiroaki Tamba, Shuntaro Matsumoto, Kenichi Hakamada
Publikováno v:
BMC Surgery, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Background Determine whether robotic surgery is more effective than transanal and conventional laparoscopic surgery in preserving bowel and urinary function after total mesorectal excision (TME). Methods Of 79 lower rectal cancer patients wh
Externí odkaz:
https://doaj.org/article/6bfef471e4fb4cabb190004db4cf9e96
Autor:
Miyuki Kubota, Motoko Kawashima, Sachiko Inoue, Toshihiro Imada, Shigeru Nakamura, Shunsuke Kubota, Mitsuhiro Watanabe, Ryo Takemura, Kazuo Tsubota
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract The incidence of dry eye disease is increasing worldwide because of the aging population and increasing use of information technology. Dry eye disease manifests as tear-layer instability and inflammation caused by osmotic hypersensitization
Externí odkaz:
https://doaj.org/article/ad49727e1bbb448384830f2eb0775214
Autor:
Taiichi Wakiya, Keinosuke Ishido, Norihisa Kimura, Hayato Nagase, Shunsuke Kubota, Hiroaki Fujita, Yusuke Hagiwara, Taishu Kanda, Masashi Matsuzaka, Yoshihiro Sasaki, Kenichi Hakamada
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
Massive intraoperative blood loss (IBL) negatively influence outcomes after surgery for pancreatic ductal adenocarcinoma (PDAC). However, few data or predictive models are available for the identification of patients with a high risk for massive IBL.
Externí odkaz:
https://doaj.org/article/50323a741cea4a9ca7419758d8f209f0
Autor:
Yo Sasaki, Hiroki Kakita, Shunsuke Kubota, Abdoulaye Sene, Tae Jun Lee, Norimitsu Ban, Zhenyu Dong, Joseph B Lin, Sanford L Boye, Aaron DiAntonio, Shannon E Boye, Rajendra S Apte, Jeffrey Milbrandt
Publikováno v:
eLife, Vol 9 (2020)
Leber congenital amaurosis type nine is an autosomal recessive retinopathy caused by mutations of the NAD+ synthesis enzyme NMNAT1. Despite the ubiquitous expression of NMNAT1, patients do not manifest pathologies other than retinal degeneration. Her
Externí odkaz:
https://doaj.org/article/4275e0ca179049eabb78a4c6222a8885
Autor:
Norimitsu Ban, Yoko Ozawa, Hideto Osada, Jonathan B. Lin, Eriko Toda, Mitsuhiro Watanabe, Kenya Yuki, Shunsuke Kubota, Rajendra S. Apte, Kazuo Tsubota
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 3, Iss 1, Pp 1-10 (2017)
Author Summary Sirtuins are nicotinamide adenine dinucleotide-dependent protein deacetylases. Among seven sirtuins, SIRT3 is a key regulator of mitochondrial function. However, functions of SIRT3 in the retina are largely unknown. In this study, we i
Externí odkaz:
https://doaj.org/article/92495cab1dba4cccbc679a25927d2256
Autor:
Jonathan B. Lin, Shunsuke Kubota, Norimitsu Ban, Mitsukuni Yoshida, Andrea Santeford, Abdoulaye Sene, Rei Nakamura, Nicole Zapata, Miyuki Kubota, Kazuo Tsubota, Jun Yoshino, Shin-ichiro Imai, Rajendra S. Apte
Publikováno v:
Cell Reports, Vol 17, Iss 1, Pp 69-85 (2016)
Photoreceptor death is the endpoint of many blinding diseases. Identifying unifying pathogenic mechanisms in these diseases may offer global approaches for facilitating photoreceptor survival. We found that rod or cone photoreceptor-specific deletion
Externí odkaz:
https://doaj.org/article/ad5b3619cf5149aa8ea7fff5633aedfd