Zobrazeno 1 - 10
of 213
pro vyhledávání: '"Shunsuke IMAI"'
Autor:
Shun Kaneko, Shunsuke Imai, Tomomi Uchikubo-Kamo, Tamao Hisano, Nobuaki Asao, Mikako Shirouzu, Ichio Shimada
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract G-protein-coupled receptors (GPCRs) play pivotal roles in various physiological processes. These receptors are activated to different extents by diverse orthosteric ligands and allosteric modulators. However, the mechanisms underlying these
Externí odkaz:
https://doaj.org/article/8986cdcaf6aa480fa00140791f388d6f
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Many RNA viruses employ internal ribosome entry sites (IRESs) in their genomic RNA to commandeer the host’s translational machinery for replication. The IRES from encephalomyocarditis virus (EMCV) interacts with eukaryotic translation init
Externí odkaz:
https://doaj.org/article/78178287e2944361b00c4f2ec6822014
Autor:
Ryosuke Murai, Keisuke Kida, Hiroshi Suzuki, Yasushi Sakata, Takayuki Ise, Shin-ichiro Miura, HIROKAZU KONDO, Yuichi Tamura, Misato Chimura, Tatsunori Taniguchi, Kensuke Takabayashi, Shinji Koba, Hiroyuki Miura, Emi Maekawa, Koki Matsuo, Wataru Fujimoto, Shunsuke Imai, Hideki Origuchi, Akiko Goda, Ryotaro Saita, Atsushi Kikuchi
Publikováno v:
BMJ Open, Vol 13, Iss 8 (2023)
Introduction Cardiac rehabilitation (CR) is strongly recommended as a medical treatment to improve the prognosis and quality of life of patients with heart failure (HF); however, participation rates in CR are low compared with other evidence-based tr
Externí odkaz:
https://doaj.org/article/f7e6450e596e4ed088c8e628c4bcd1c3
Autor:
Hideaki Ota, Hitoshi Matsuo, Shunsuke Imai, Yuki Nakashima, Yoshiaki Kawase, Munenori Okubo, Hiroshi Takahashi, Hideki Kawai, Yoshihiro Sobue, Masanori Kawasaki, Takeshi Kondo, Takashi Muramatsu, Hideo Izawa
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
BackgroundThis study compares the efficacy of coronary computed tomography angiography (CCTA) and near-infrared spectroscopy intravascular ultrasound (NIRS–IVUS) in patients with significant coronary stenosis for predicting periprocedural myocardia
Externí odkaz:
https://doaj.org/article/9f02279eb8bf4070840438998582baba
Autor:
Kazuki Matsumura, Takushi Shimomura, Yoshihiro Kubo, Takayuki Oka, Naohiro Kobayashi, Shunsuke Imai, Naomi Yanase, Madoka Akimoto, Masahiro Fukuda, Mariko Yokogawa, Kazuyoshi Ikeda, Jun-ichi Kurita, Yoshifumi Nishimura, Ichio Shimada, Masanori Osawa
Publikováno v:
BMC Molecular and Cell Biology, Vol 22, Iss 1, Pp 1-16 (2021)
Abstract Background Human ether-à-go-go-related gene potassium channel 1 (hERG) is a voltage-gated potassium channel, the voltage-sensing domain (VSD) of which is targeted by a gating-modifier toxin, APETx1. APETx1 is a 42-residue peptide toxin of s
Externí odkaz:
https://doaj.org/article/fefcd79f84134514b7e6ed26583065d2
Autor:
Yuta Iwahashi, Yuki Toyama, Shunsuke Imai, Hiroaki Itoh, Masanori Osawa, Masayuki Inoue, Ichio Shimada
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Potassium ion channels control K+ permeation across cell membranes and mutations that cause cardiovascular and neural diseases are known. Here, the authors perform NMR measurements with the prototypical K+ channel from Streptomyces lividans, KcsA and
Externí odkaz:
https://doaj.org/article/1e91ff52d72149278985a050c03132cb
Autor:
Hanaho Kano, Yuki Toyama, Shunsuke Imai, Yuta Iwahashi, Yoko Mase, Mariko Yokogawa, Masanori Osawa, Ichio Shimada
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Opening of G protein-gated inwardly rectifying potassium channels (GIRK) is coupled to the activation of a GPCR. Here the authors use NMR and cell-based BRET assays to gain insights into the mechanisms underlying family-specific activation and find t
Externí odkaz:
https://doaj.org/article/1d3c5f17ee3f414881ec083bebb5692c
Autor:
Ryoichi Sawazaki, Shunsuke Imai, Mariko Yokogawa, Nao Hosoda, Shin-ichi Hoshino, Muneyo Mio, Kazuhiro Mio, Ichio Shimada, Masanori Osawa
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract Eukaryotic mature mRNAs possess a poly adenylate tail (poly(A)), to which multiple molecules of poly(A)-binding protein C1 (PABPC1) bind. PABPC1 regulates translation and mRNA metabolism by binding to regulatory proteins. To understand funct
Externí odkaz:
https://doaj.org/article/72a8c212de0b4c6b858a335b08566f8e
Autor:
Yutaro Shiraishi, Mei Natsume, Yutaka Kofuku, Shunsuke Imai, Kunio Nakata, Toshimi Mizukoshi, Takumi Ueda, Hideo Iwaï, Ichio Shimada
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Upon stimulation by agonist binding, the C-terminal regions of G-protein-coupled receptors (GPCRs) become phosphorylated by GPCR kinases, and phosphorylated GPCRs bind arrestin. Here the authors give structural insights into the phosphorylation induc
Externí odkaz:
https://doaj.org/article/11dca4d48ec6418dbf505466ac65a7b4
Autor:
Koh Takeuchi, Yutaka Kofuku, Shunsuke Imai, Takumi Ueda, Yuji Tokunaga, Yuki Toyama, Yutaro Shiraishi, Ichio Shimada
Publikováno v:
Membranes, Vol 11, Iss 8, p 604 (2021)
A primary biological function of multi-spanning membrane proteins is to transfer information and/or materials through a membrane by changing their conformations. Therefore, particular dynamics of the membrane proteins are tightly associated with thei
Externí odkaz:
https://doaj.org/article/399a52ea34974dbb844af3cc8f0e5f6e