Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Shunsuke Einaru"'
Autor:
Ann Vos, Lieve Lammens, Richard Alexander, Frederik J. R. Rombouts, Michel Surkyn, Kenji Morimoto, Laurent Leclercq, Nigel Austin, Koichi Tsubone, Tatsuhiko Ueno, Michel Anna Jozef De Cleyn, Deborah Dhuyvetter, Ken-ichi Kusakabe, Ard Teisman, Diederik Moechars, Tom Jacobs, An Van Den Bergh, Hirokazu Sumiyoshi, Herman Borghys, Shunsuke Einaru, Soufyan Jerhaoui, Brian Joel Hrupka, Harrie J.M. Gijsen
Publikováno v:
Journal of Medicinal Chemistry. 64:14175-14191
The discovery of a novel 2-aminotetrahydropyridine class of BACE1 inhibitors is described. Their pKa and lipophilicity were modulated by a pending sulfonyl group, while good permeability and brain penetration were achieved via intramolecular hydrogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b24d041c262542cc337ea98b8c94c5e
https://doi.org/10.1021/acs.jmedchem.1c00935
https://doi.org/10.1021/acs.jmedchem.1c00935
Autor:
Shiho Yamamoto, Hisanori Ito, Takushi Kanazu, Shunsuke Einaru, Shuji Yonezawa, Norihiko Tanimoto, Takahiko Yamamoto, Luc Tritsmans, Takuya Oguma, Akira Kato, Gaku Sakaguchi, Ken-ichi Kusakabe, Katsunori Sakai, Tatsuhiko Ueno, Akihiro Matsuda, Akihiro Hori, Kenji Morimoto, Yoshitaka Yamaguchi, Yoshiyasu Baba, Maarten Timmers, Naoya Asada, Koriyama Yuji
Publikováno v:
Journal of Medicinal Chemistry. 64:1873-1888
Accumulation of amyloid β peptides (Aβ) is thought to be one of the causal factors of Alzheimer's disease (AD). The aspartyl protease β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the rate-limiting protease for Aβ production, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7261e2c9798f2ee4c20472d855dc9f1
https://doi.org/10.1021/acs.jmedchem.0c01917
https://doi.org/10.1021/acs.jmedchem.0c01917
Publikováno v:
European Journal of Organic Chemistry. 2020:7131-7133
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e613bda004a9632fd119f03acbe5214
https://doi.org/10.1002/ejoc.202000956
https://doi.org/10.1002/ejoc.202000956
Autor:
Shunsuke Einaru, Kenta Shitamichi, Tagui Nagano, Akira Matsumoto, Keisuke Asano, Seijiro Matsubara
Publikováno v:
Angewandte Chemie. 130:14059-14063
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71abcb06dcc0928161f0140b9e115096
https://doi.org/10.1002/ange.201808320
https://doi.org/10.1002/ange.201808320
Autor:
Rombouts, Frederik J. R., Ken-ichi Kusakabe, Alexander, Richard, Austin, Nigel, Borghys, Herman, De Cleyn, Michel, Dhuyvetter, Deborah, Gijsen, Harrie J. M., Hrupka, Brian, Jacobs, Tom, Jerhaoui, Soufyan, Lammens, Lieve, Leclercq, Laurent, Tsubone, Koichi, Tatsuhiko Ueno, Kenji Morimoto, Shunsuke Einaru, Hirokazu Sumiyoshi, Van den Bergh, An, Ann Vos
Publikováno v:
Journal of Medicinal Chemistry; 10/14/2021, Vol. 64 Issue 19, p14175-14191, 17p
Publikováno v:
European Journal of Organic Chemistry. 2020:7101-7101
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b80ca301e2f4272e88dff6843ff0bffb
https://doi.org/10.1002/ejoc.202001293
https://doi.org/10.1002/ejoc.202001293