Zobrazeno 1 - 10
of 277
pro vyhledávání: '"Shunsei Hirohata"'
Autor:
Shunsei Hirohata, Hirotoshi Kikuchi
Publikováno v:
ACR Open Rheumatology, Vol 3, Iss 1, Pp 42-49 (2021)
Objective The present study was designed in order to elucidate the roles of serum interleukin 6 (IL‐6) in the pathogenesis in neuropsychiatric systemic lupus erythematosus (NPSLE). Methods Paired serum and cerebrospinal fluid (CSF) samples were obt
Externí odkaz:
https://doaj.org/article/ec666edafacd4bca8eeca376cefc96cf
Autor:
Toshihiro Tono, Satoko Aihara, Takayuki Hoshiyama, Yoshiyuki Arinuma, Tatsuo Nagai, Shunsei Hirohata
Publikováno v:
Inflammation and Regeneration, Vol 37, Iss 1, Pp 1-6 (2017)
Abstract Background Abatacept, a CTLA4-Ig fusion protein attenuates T cell activation by inhibiting the CD80/86-CD28 costimulatory pathway that is required for the proper T cell activation and thus displays beneficial effects in the treatment of rheu
Externí odkaz:
https://doaj.org/article/b0de17aae348438480976dffb202ebfd
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0209282 (2018)
The present study was performed to elucidate the roles of serum anti-Sm antibodies in the pathogenesis of systemic lupus erythematosus (SLE). Highly purified peripheral blood monocytes obtained from healthy donors were cultured in the presence of mon
Externí odkaz:
https://doaj.org/article/bafc93b2edba4602b0ef0e6431272b0a
Autor:
Tomoyuki Asano, Hiromi Ito, Yoshinobu Kariya, Kyoka Hoshi, Akioh Yoshihara, Yoshikazu Ugawa, Hideharu Sekine, Shunsei Hirohata, Yoshiki Yamaguchi, Shuzo Sato, Hiroko Kobayashi, Kiyoshi Migita, Hiromasa Ohira, Yasuhiro Hashimoto, Hiroshi Watanabe
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186414 (2017)
Although quotient of alpha2 macroglobulin (Qα2MG) was previously reported to be useful for the evaluation of blood-brain barrier (BBB) function, it is not commonly used. We therefore evaluated BBB function among the various subsets of neuropsychiatr
Externí odkaz:
https://doaj.org/article/e6d07c93e8ba4fbdb37b190c50aba7f7
Autor:
Yuki Hachiya, Aya Kawasaki, Shomi Oka, Yuya Kondo, Satoshi Ito, Isao Matsumoto, Makio Kusaoi, Hirofumi Amano, Akiko Suda, Keigo Setoguchi, Tatsuo Nagai, Kota Shimada, Shoji Sugii, Akira Okamoto, Noriyuki Chiba, Eiichi Suematsu, Shigeru Ohno, Masao Katayama, Hajime Kono, Shunsei Hirohata, Yoshinari Takasaki, Hiroshi Hashimoto, Takayuki Sumida, Shouhei Nagaoka, Shigeto Tohma, Hiroshi Furukawa, Naoyuki Tsuchiya
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0158065 (2016)
HLA-G plays a role in fetal-maternal tolerance as well as immunoregulation, and has been suggested to be involved in autoimmune diseases and cancers. HLA-G encodes two potentially functional polymorphisms in the 3' untranslated region, 14bp insertion
Externí odkaz:
https://doaj.org/article/ce99e4571a094b20b55b37041b0b37cf
Autor:
Hiroshi Furukawa, Shomi Oka, Aya Kawasaki, Kota Shimada, Shoji Sugii, Takashi Matsushita, Atsushi Hashimoto, Akiko Komiya, Naoshi Fukui, Kouji Kobayashi, Atsumu Osada, Atsushi Ihata, Yuya Kondo, Tatsuo Nagai, Keigo Setoguchi, Akiko Okamoto, Akira Okamoto, Noriyuki Chiba, Eiichi Suematsu, Hajime Kono, Masao Katayama, Shunsei Hirohata, Takayuki Sumida, Kiyoshi Migita, Minoru Hasegawa, Manabu Fujimoto, Shinichi Sato, Shouhei Nagaoka, Kazuhiko Takehara, Shigeto Tohma, Naoyuki Tsuchiya
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0154255 (2016)
Several studies on associations between human leukocyte antigen (HLA) allele frequencies and susceptibility to systemic sclerosis (SSc) have been reported. Anti-centromere antibodies (ACA) and anti-topoisomerase I antibodies (ATA) are found in SSc pa
Externí odkaz:
https://doaj.org/article/420033d6607340dfbf100fabe0b10284
Autor:
Aya Kawasaki, Hiroshi Furukawa, Nao Nishida, Eiji Warabi, Yuya Kondo, Satoshi Ito, Isao Matsumoto, Makio Kusaoi, Hirofumi Amano, Akiko Suda, Shouhei Nagaoka, Keigo Setoguchi, Tatsuo Nagai, Shunsei Hirohata, Kota Shimada, Shoji Sugii, Akira Okamoto, Noriyuki Chiba, Eiichi Suematsu, Shigeru Ohno, Masao Katayama, Akiko Okamoto, Hajime Kono, Katsushi Tokunaga, Yoshinari Takasaki, Hiroshi Hashimoto, Takayuki Sumida, Shigeto Tohma, Naoyuki Tsuchiya
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109764 (2014)
Interferon regulatory factor 2 (IRF2) negatively regulates type I interferon (IFN) responses, while it plays a role in induction of Th1 differentiation. Previous linkage and association studies in European-American populations suggested genetic role
Externí odkaz:
https://doaj.org/article/e07e5f3a91cb4d4ba95ba8cd4556417a
Autor:
Hiroshi Furukawa, Aya Kawasaki, Shomi Oka, Ikue Ito, Kota Shimada, Shoji Sugii, Atsushi Hashimoto, Akiko Komiya, Naoshi Fukui, Yuya Kondo, Satoshi Ito, Taichi Hayashi, Isao Matsumoto, Makio Kusaoi, Hirofumi Amano, Tatsuo Nagai, Shunsei Hirohata, Keigo Setoguchi, Hajime Kono, Akira Okamoto, Noriyuki Chiba, Eiichi Suematsu, Masao Katayama, Kiyoshi Migita, Akiko Suda, Shigeru Ohno, Hiroshi Hashimoto, Yoshinari Takasaki, Takayuki Sumida, Shouhei Nagaoka, Naoyuki Tsuchiya, Shigeto Tohma
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87792 (2014)
Many studies on associations between human leukocyte antigen (HLA) allele frequencies and susceptibility to systemic lupus erythematosus (SLE) have been performed. However, few protective associations with HLA-DRB1 alleles have been reported. Here, w
Externí odkaz:
https://doaj.org/article/74a646716d404b239f4f8a3d2f04a032
Autor:
Hiroshi Furukawa, Shomi Oka, Kota Shimada, Shoji Sugii, Atsushi Hashimoto, Akiko Komiya, Naoshi Fukui, Tatsuo Nagai, Shunsei Hirohata, Keigo Setoguchi, Akira Okamoto, Noriyuki Chiba, Eiichi Suematsu, Taiichiro Miyashita, Kiyoshi Migita, Akiko Suda, Shouhei Nagaoka, Naoyuki Tsuchiya, Shigeto Tohma
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53910 (2013)
INTRODUCTION: Autoantibodies to ribonucleoprotein are associated with a variety of autoimmune diseases, including rheumatoid arthritis (RA). Many studies on associations between human leukocyte antigen (HLA) alleles and RA have been reported, but few
Externí odkaz:
https://doaj.org/article/4c6073feb3844c00802a46a3aa110e47
Autor:
Shunsei Hirohata, Hirotoshi Kikuchi, Tetsuji Sawada, Masataka Kuwana, Izumi Kawachi, Yohei Kirino, Yoshiaki Ishigatsubo, Mitsuhiro Takeno
Publikováno v:
Internal Medicine; 2024, Vol. 63 Issue 4, p481-486, 6p