Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Shunqi Yan"'
Autor:
Alberto Bardelli, Salvatore Siena, Gang Li, Andrea Sartore Bianchi, Federica Di Nicolantonio, Robert Wild, Robert Shoemaker, Shunqi Yan, Roopal Patel, Nicholas Cam, Alice Bartolini, Benedetta Mussolin, Luca Novara, Giuseppe Rospo, Giorgio Corti, Luca Lazzari, Giovanni Crisafulli, Giulia Siravegna, Ge Wei, Sandra Misale, Mariangela Russo
Supplementary Figure S1. LMNA-NTRK1 genetic rearrangement detected in patient's plasma and xeno. Supplementary Figure S2. Acquisition of mutations in the TRKA kinase domain drives secondary resistance to entrectinib in Ba/F3 TRKA WT cells. Supplement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057302585d4404e254351678a966601f
https://doi.org/10.1158/2159-8290.22531250.v1
https://doi.org/10.1158/2159-8290.22531250.v1
Autor:
Alexander Drilon, Marc Ladanyi, Pratik Multani, Rupal Patel, Jennifer W. Oliver, Ge Wei, Shunqi Yan, Jason Harris, Gregory J. Riely, Eric Martin, Anni Schairer, Aleksandra Franovic, Leenus Martin, Takuo Hayashi, Roger S. Smith, James Joseph, Romel Somwar, Gang G. Li
Supplementary Figure 1. In vitro characterization of RET inhibitory activity of RXDX-105 in HBEC3KT-RET cells; Supplementary Figure 2. In vivo efficacy of RXDX-105 in a xenograft model of HBEC3KT-RET harboring CCDC6-RET fusion.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bf2627da5d44cfbb7ffef3f298ea800
https://doi.org/10.1158/1078-0432.22462959
https://doi.org/10.1158/1078-0432.22462959
Autor:
Alexander Drilon, Marc Ladanyi, Pratik Multani, Rupal Patel, Jennifer W. Oliver, Ge Wei, Shunqi Yan, Jason Harris, Gregory J. Riely, Eric Martin, Anni Schairer, Aleksandra Franovic, Leenus Martin, Takuo Hayashi, Roger S. Smith, James Joseph, Romel Somwar, Gang G. Li
Purpose: While multikinase inhibitors with RET activity are active in RET-rearranged thyroid and lung cancers, objective response rates are relatively low and toxicity can be substantial. The development of novel RET inhibitors with improved potency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b105702602221e55d28aa4cdca2dd19
https://doi.org/10.1158/1078-0432.c.6525270.v1
https://doi.org/10.1158/1078-0432.c.6525270.v1
Autor:
Alexander Drilon, Marc Ladanyi, Pratik Multani, Rupal Patel, Jennifer W. Oliver, Ge Wei, Shunqi Yan, Jason Harris, Gregory J. Riely, Eric Martin, Anni Schairer, Aleksandra Franovic, Leenus Martin, Takuo Hayashi, Roger S. Smith, James Joseph, Romel Somwar, Gang G. Li
Supplementary figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8744d89bf98cc5c97a904a370b94485d
https://doi.org/10.1158/1078-0432.22462962.v1
https://doi.org/10.1158/1078-0432.22462962.v1
Autor:
Jennifer W. Oliver, Gang G Li, Ge Wei, Annelie E. Abrahamsson Schairer, Romel Somwar, Takuo Hayashi, Aleksandra Franovic, Pratik S. Multani, Rupal Patel, James Joseph, Shunqi Yan, Marc Ladanyi, Leenus Martin, Gregory J. Riely, Eric S. Martin, Alexander Drilon, Jason Harris, Roger S. Smith
Publikováno v:
Clinical Cancer Research. 23:2981-2990
Purpose: While multikinase inhibitors with RET activity are active in RET-rearranged thyroid and lung cancers, objective response rates are relatively low and toxicity can be substantial. The development of novel RET inhibitors with improved potency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63d8950f51ca5bdd465056e4fce2dddd
https://doi.org/10.1158/1078-0432.ccr-16-1887
https://doi.org/10.1158/1078-0432.ccr-16-1887
Autor:
Luca Novara, Giovanni Crisafulli, Salvatore Siena, Federica Di Nicolantonio, R. Patel, Alberto Bardelli, Giuseppe Rospo, Giorgio Corti, Giulia Siravegna, Ge Wei, Luca Lazzari, Andrea Bianchi, Sandra Misale, Mariangela Russo, Benedetta Mussolin, Nicholas Cam, Robert H. Shoemaker, Gang Li, Alice Bartolini, Robert A. Wild, Shunqi Yan
Publikováno v:
Cancer Discovery. 6:36-44
Entrectinib is a first-in-class pan-TRK kinase inhibitor currently undergoing clinical testing in colorectal cancer and other tumor types. A patient with metastatic colorectal cancer harboring an LMNA–NTRK1 rearrangement displayed a remarkable resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba15b7a031767652f73d9b23341a339
https://doi.org/10.1158/2159-8290.cd-15-0940
https://doi.org/10.1158/2159-8290.cd-15-0940
Autor:
Shunqi Yan, Scott A. Biller, Fang Wang, David P. Schenkein, Marion Dorsch, Shinsan M. Su, Jeffrey O. Saunders, Jeremy Travins, Wentao Wei, Kimberly Straley, Wei Liu, Stefan Gross, Camelia Gliser, Lenny Dang, Elena Mylonas, Hua Yang, Sam Agresta, Erica Hansen, Véronique Saada, Stéphane de Botton, Byron DeLaBarre, Katharine E. Yen, Janeta Popovici-Muller, Stuart Murray, Erin Artin, Stefanie Schalm, Cyril Quivoron, Andrew Kernytsky, Virginie Penard-Lacronique, Yi Gao, Francesco G. Salituro
Publikováno v:
Science. 340:622-626
IDHology Among the most exciting drug targets to emerge from cancer genome sequencing projects are two related metabolic enzymes, isocitrate dehydrogenases 1 and 2 (IDH1, IDH2). Mutations in the IDH1 and IDH2 genes are common in certain types of huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29fb3aa7882e5c926f2b401241cd644f
https://doi.org/10.1126/science.1234769
https://doi.org/10.1126/science.1234769
Autor:
Gang G, Li, Romel, Somwar, James, Joseph, Roger S, Smith, Takuo, Hayashi, Leenus, Martin, Aleksandra, Franovic, Anni, Schairer, Eric, Martin, Gregory J, Riely, Jason, Harris, Shunqi, Yan, Ge, Wei, Jennifer W, Oliver, Rupal, Patel, Pratik, Multani, Marc, Ladanyi, Alexander, Drilon
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 23(12)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::91049061c6f5ea54258cab2e386e715f
https://pubmed.ncbi.nlm.nih.gov/28011461
https://pubmed.ncbi.nlm.nih.gov/28011461
Autor:
Shinsan M. Su, Shunqi Yan, Ed Driggers, Wentao Wei, Cheng Fang, Shengfang Jin, Jeff Hixon, Yi Gao, Giovanni Cianchetta, Francesco G. Salituro, Lewis C. Cantley, Kevin Qian, Fan Jiang, Sung Choe, Kaiko Kunii, Matthew G. Vander Heiden, Shalini Sethumadhavan, Erin Murphy, Katharine E. Yen, Stuart Murray, Hin Koon Woo, Charles Kung, Jeffrey O. Saunders, Shaohui Wang, Xiling Wang, Wei Liu, Lenny Dang, Kevin Marks, Byron DeLaBarre, Stefan Gross, Hua Yang
Publikováno v:
Chemistry & Biology. 19(9):1187-1198
SummaryProliferating tumor cells use aerobic glycolysis to support their high metabolic demands. Paradoxically, increased glycolysis is often accompanied by expression of the lower activity PKM2 isoform, effectively constraining lower glycolysis. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::606aa052e44f56bf326011d5541703c7
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:1991-1995
A novel series of thiazolone-acylsulfonamides were designed as HCV NS5B polymerase allosteric inhibitors. The structure based drug designs (SBDD) were guided by docking results that revealed the potential to explore an additional pocket in the allost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c37882f9e3b768a256e444ed41567e12
https://doi.org/10.1016/j.bmcl.2007.01.024
https://doi.org/10.1016/j.bmcl.2007.01.024