Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Shunji Shinohara"'
Autor:
Atsushi Nakamura, Hiroko Ono, Azusa Ando, Mikie Hinata, Kazuki Niidome, Shigeki Omachi, Gaku Sakaguchi, Shunji Shinohara
Publikováno v:
Journal of Pharmacological Sciences, Vol 133, Iss 1, Pp 9-17 (2017)
We investigated the mechanisms underlying the suppression of the rewarding effects of opioids using the femur bone cancer (FBC) mouse model. The rewarding and antinociceptive effects of subcutaneously administered morphine and oxycodone in the FBC mo
Externí odkaz:
https://doaj.org/article/46245ec94f2840988654d3441227fa84
Autor:
Hiroko Ono, Atsushi Nakamura, Tomoe Kanbara, Kazuhisa Minami, Shunji Shinohara, Gaku Sakaguchi, Toshiyuki Kanemasa
Publikováno v:
Journal of Pharmacological Sciences, Vol 125, Iss 3, Pp 264-273 (2014)
Abstract.: Although norepinephrine transporter (NET) inhibition has an additional effect on μ-opioid receptor (MOR)-mediated anti-nociception in inflammatory and neuropathic pain, its effect on cancer pain is not well characterized. We investigated
Externí odkaz:
https://doaj.org/article/61ad8022d4804940a7e6483c74296ab5
Autor:
Minoru Tomida, Kosuke Anan, Shoichi Yamamoto, Shunji Shinohara, Aya Tazawa, Nobuyoshi Hasebe, Shigenori Yagi, Masaharu Kume, Shinji Shimada, Yoshihiro Haga, Moriyasu Masui, Hiroyuki Kai, Hiroki Tsuji
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:1143-1147
Selective N-methyl- d -aspartate receptor subunit 2B (NR2B) antagonists show potential as analgesic drugs, and do not cause side effects associated with non-selective N-methyl- d -aspartate (NMDA) antagonists. Using a scaffold-hopping approach, we pr
Autor:
Ryuta Tamano, Minoru Hasegawa, Sosuke Yoneda, Masatomo Rokushima, Gaku Sakaguchi, Masahide Fujita, Erika Yogo, Toshiyuki Asaki, Shigeki Omachi, Shunji Shinohara
Publikováno v:
European Journal of Pharmacology. 833:263-274
Microglia exhibit various activation phenotypes in the spinal cord after peripheral nerve injury, and promote neuropathic pain. Ibudilast is a phosphodiesterase inhibitor with anti-inflammatory activity, but its effect on activated microglia in chron
Autor:
Hiroyuki Kai, Natsuki Ishizuka, Masaharu Kume, Fumiyo Takahashi, Takayuki Kameyama, Shunji Shinohara, Maki Tomari, Shinji Shimada, Naotake Kobayashi, Yoshikazu Tanaka, Haruki Kinoshita, Miho Oohara, Hiroyuki Tobinaga, Masahide Ohdan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:2338-2342
The P2X3 receptor is primarily expressed in the peripheral sensory nerves, and therefore, antagonists of this receptor may be useful for the treatment of chronic pain. Pyrrolinone derivatives have been identified as a novel class of P2X3 receptor ant
Autor:
Naotaka Horiguchi, Mika Kobayashi, Koji Yano, Minoru Hasegawa, Shunji Shinohara, Kouhei Nishitomi, Kohei Jino, Takuya Kano
Publikováno v:
Behavioural Brain Research. 345:21-29
Impulsive choice behavior, which can be assessed using the delay discounting task, is a characteristic of various psychiatric disorders, including attention-deficit/hyperactivity disorder (ADHD). Guanfacine is a selective α2A-adrenergic receptor ago
Autor:
Hiroyuki Kai, Takuya Shintani, Ryouko Sekimoto, Erika Kasai, Yasuhiko Fujii, Yusuke Ichihashi, Kazuhisa Minami, Noriyuki Kurose, Murakami Yuki, Naohiro Itoh, Osamu Yoshida, Shunji Shinohara, Hirai Keiichiro, Naohiro Onodera, Sosuke Yoneda, Takayuki Kameyma, Hiroko Ogawa, Kenichiroh Nakamura, Tohru Horiguchi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 52:128384
In previous work, we discovered a lead compound and conducted initial SAR studies on a novel series of dioxotriazines to identify the compound as one of the P2X3 receptor antagonists. This compound showed high P2X3 receptor selectivity and a strong a
Autor:
Yasuhiko Kanda, Maki Tomari, Tohru Horiguchi, Kayoko Hata, Hiroyuki Kai, Emiko Taniguchi, Tsuyoshi Hasegawa, Shunji Shinohara, Takayuki Kameyama, Yoshiyuki Taoda, Miho Oohara, Shinji Shimada, Yukio Takahara, Yoshikazu Tanaka, Naoko Kurihara, Yukio Tada, Hiroyuki Tobinaga, Chie Takeyama, Shigenori Yagi, Shoichi Yamamoto, Fumiyo Takahashi, Kentarou Asahi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127636
The P2X3 receptor is an attractive target for the treatment of pain and chronic coughing, and thus P2X3 antagonists have been developed as new therapeutic drugs. We previously reported selective P2X3 receptor antagonists by derivatization of hit comp
Publikováno v:
Neuroscience Letters. 615:78-82
Dysfunction in the central serotonin (5-HT) and norepinephrine (NE) systems cause depression and pain. Descending spinal pain modulatory pathways are important in the analgesic mechanisms of antidepressants, particularly serotonin and norepinephrine
Publikováno v:
European Journal of Pharmacology. 772:11-21
We investigated functional alterations of voltage-gated calcium channels (VGCCs) in excitatory synaptic transmission from primary afferent A- and C-fibers after peripheral nerve injury. Patch-clamp recordings were performed on substantia gelatinosa (