Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Shunji Nagahara"'
Autor:
Takuji Ishimoto, Shinichiro Inaba, Yoshifumi Takei, Yuzo Tarumi, Seiichi Matsuo, Kenji Kadomatsu, Naoki Makita, Shunji Nagahara
Publikováno v:
Molecular Therapy. 20(2):356-366
Short interfering RNA (siRNA) is a potent activator of the mammalian innate immune system. When considering possible clinical applications of siRNA for humans, the adverse immunostimulatory effects must also be taken into account. Here, we show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee9377a9139f422980cc2b06da242fc5
Autor:
Naoki Makita, Shunji Nagahara
Publikováno v:
Drug Delivery System. 25:607-614
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b94c1081553767177082a233da9ab57
https://doi.org/10.2745/dds.25.607
https://doi.org/10.2745/dds.25.607
Publikováno v:
Expert Opinion on Drug Discovery. 2:159-167
RNA interference (RNAi) was first reported in nematodes in 1998. Since that time, RNAi has been discovered in fish, insects and mammals. Novel treatments and drug discovery in preclinical studies based on RNAi are targeting a wide range of diseases a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2548b538ee56b4714fc5313524deffd4
https://doi.org/10.1517/17460441.2.2.159
https://doi.org/10.1517/17460441.2.2.159
Autor:
Akihiko Sano, Tomoko Hata, Takahiro Nemoto, Kunihiko Nakazawa, Shunji Nagahara, Yutaka Nagai, Hiroshi Itoh, Shunichiro Kubota, Yousuke Seyama
Publikováno v:
Cancer. 109:993-1002
BACKGROUND Substantial evidence supports a direct role of ornithine decarboxylase (ODC) in the development and maintenance of human tumors. Although antisense oligonucleotide therapy targeting various genes are useful for cancer treatment, 1 of the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d304962ca31b480aae4204ae73f2f9b
https://doi.org/10.1002/cncr.22483
https://doi.org/10.1002/cncr.22483
Autor:
Koji Hanai, Miho Maeda, Yoshiko Minakuchi, Takahiro Ochiya, Fumitaka Takeshita, Kimi Honma, Akihiko Sano, Shunji Nagahara
Publikováno v:
Annals of the New York Academy of Sciences. 1082:9-17
The goal of our research is to provide a practical platform for drug delivery in oligonucleotide therapy. We report here the efficacy of an atelocollagen-mediated oligonucleotide delivery system applied to systemic siRNA and antisense oligonucleotide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b197d8e8fd904dd24b69774bc05bf2c4
https://doi.org/10.1196/annals.1348.010
https://doi.org/10.1196/annals.1348.010
Autor:
Takahiro Ochiya, Koji Hanai, Shunji Nagahara, Akihiko Sano, Tomoyo Kurokawa, Miho Maeda, Teruo Miyata, Yoshiko Minakuchi
Publikováno v:
Human Gene Therapy. 15:263-272
To study the possibility of using atelocollagen as an oligonucleotide (ODN) delivery carrier in vivo, the activity of formulated antisense ODN targeted against the intercellular adhesion molecule-1 (ICAM-1) mRNA was investigated in an allergic dermat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2d66e765674788e39c3ad53748b5efd
https://doi.org/10.1089/104303404322886110
https://doi.org/10.1089/104303404322886110
Publikováno v:
Drug Delivery System. 19:356-363
siRNAを用いた遺伝子発現抑制技術はin vitro, in vivoにおいて遺伝子機能解析の有力な手法の一つである. siRNAはアンチセンスDNAに比較して手法が単純でありかつ効果が高いことから, 医薬品と
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fb6fb9b2a67b1a98f6ae5c8f3022f62
https://doi.org/10.2745/dds.19.356
https://doi.org/10.2745/dds.19.356
Autor:
Akihiko Sano, Hiroshi Itoh, Keiji Fujioka, Kimi Honma, Takahiro Ochiya, Miho Maeda, Shunji Nagahara, Teruo Miyata
Publikováno v:
Advanced Drug Delivery Reviews. 55:1651-1677
Recent progress in recombinant gene technology and cell culture technology has made it possible to use protein and polynucleotides as effective drugs. However, because of their short half-lives in the body and the necessity of delivering to target si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e331a3c9090021c85712488894d02781
https://doi.org/10.1016/j.addr.2003.08.005
https://doi.org/10.1016/j.addr.2003.08.005
Publikováno v:
Vaccine. 20:1089-1098
Two continuous delivery injectable silicone implants were tested to determine if they were capable of delivering vaccines in a single shot. The Type A implant delivers antigen in vitro over a 1-month-period and the Type B over several months. Vaccina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23f4a043e6dc6889c1de70005296a997
https://doi.org/10.1016/s0264-410x(01)00444-3
https://doi.org/10.1016/s0264-410x(01)00444-3
The application of biodegradable collagen minipellets as vaccine delivery vehicles in mice and sheep
Autor:
Garry Barcham, Shunji Nagahara, Shari Lofthouse, Akihiko Sano, Malcolm R. Brandon, Bradley J Sedgmen
Publikováno v:
Vaccine. 19:4318-4327
Collagen minipellets are injectable delivery vehicles that release antigen and adjuvant over several days in a first-order release profile. In vaccination experiments in mice, secondary antibody responses induced by minipellets formulated with avidin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d62de6eed46b81d80a5dafcd876fe29
https://doi.org/10.1016/s0264-410x(01)00153-0
https://doi.org/10.1016/s0264-410x(01)00153-0