Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Shunji Kunori"'
Autor:
Masako Uchii, Mariko Sakai, Yuhei Hotta, Satoshi Saeki, Naoya Kimoto, Akinori Hamaguchi, Tetsuya Kitayama, Shunji Kunori
Publikováno v:
Journal of Pharmacological Sciences, Vol 135, Iss 3, Pp 126-130 (2017)
Saxagliptin, a potent and selective DPP-4 inhibitor, exhibits a slow dissociation from DPP-4. We investigated the sustained effects of saxagliptin on renal DPP-4 activity in a washout study using renal tubular (HK-2) cells, and in a pharmacodynamic s
Externí odkaz:
https://doaj.org/article/4850ac17a9bd45a3be39b4af856c75ed
Publikováno v:
Journal of Pharmacological Sciences, Vol 132, Iss 1, Pp 65-70 (2016)
Saxagliptin, a potent and selective DPP-4 inhibitor, is characterized by its slow dissociation from DPP-4 and its long half-life and is expected to have a potent tissue membrane-bound DPP-4-inhibitory effect in various tissues. In the present study,
Externí odkaz:
https://doaj.org/article/ee83464ecfb542cdb2fa467b2c83faa8
Autor:
Yuhei Hotta, Shunji Kunori, Satoshi Saeki, Tetsuya Kitayama, Mariko Sakai, Masako Uchii, Naoya Kimoto, Akinori Hamaguchi
Publikováno v:
Journal of Pharmacological Sciences, Vol 135, Iss 3, Pp 126-130 (2017)
Saxagliptin, a potent and selective DPP-4 inhibitor, exhibits a slow dissociation from DPP-4. We investigated the sustained effects of saxagliptin on renal DPP-4 activity in a washout study using renal tubular (HK-2) cells, and in a pharmacodynamic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d0ab5a15e9e53d7cf51eb6bc005312
https://doi.org/10.1016/j.jphs.2017.10.003
https://doi.org/10.1016/j.jphs.2017.10.003
Publikováno v:
European Journal of Pharmacology. 783:56-63
Although previous studies have shown an important role of renal dipeptidyl peptidase-4 (DPP-4) inhibition in ameliorating kidney injury in hypertensive rats, the renal distribution of DPP-4 and mechanisms of renoprotective action of DPP-4 inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b961ec02ae45c354ef46d4165f27b67
Publikováno v:
Journal of Pharmacological Sciences, Vol 132, Iss 1, Pp 65-70 (2016)
Saxagliptin, a potent and selective DPP-4 inhibitor, is characterized by its slow dissociation from DPP-4 and its long half-life and is expected to have a potent tissue membrane-bound DPP-4-inhibitory effect in various tissues. In the present study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf08f9f8f9c65dba3da6f103f60fb6b0
https://pubmed.ncbi.nlm.nih.gov/27666017
https://pubmed.ncbi.nlm.nih.gov/27666017
Autor:
Emiko Okuda-Ashitaka, Shunji Kunori, Seiji Ito, Yoshihiro Urade, Tayo Katano, Laurent P. Audoly, Shinji Matsumura
Publikováno v:
Glia. 59:208-218
Neuropathic pain produced by damage to or dysfunction of the nervous system is a common and severely disabling state that affects millions of people worldwide. Recent evidence indicates that activated microglia are key cellular intermediaries in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1138bab423cbeb5f4c9fa43bf475e470
https://doi.org/10.1002/glia.21090
https://doi.org/10.1002/glia.21090
Autor:
Emiko Okuda-Ashitaka, Tayo Katano, Seiji Ito, Shunji Kunori, Tadashi Yamamoto, Shinji Matsumura, Tamaki Mabuchi, Masahiko Watanabe, Tetsuya Abe, Takanobu Nakazawa
Publikováno v:
European Journal of Neuroscience. 32:798-810
Ca(2+) /calmodulin-dependent protein kinase II (CaMKII) is a key mediator of long-term potentiation (LTP), which can be triggered by N-methyl-d-aspartate (NMDA) receptor-mediated Ca(2+) influx. We previously demonstrated that Fyn kinase-mediated phos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87f41a61b9ca61bba6e4bdcccbdece7c
https://doi.org/10.1111/j.1460-9568.2010.07348.x
https://doi.org/10.1111/j.1460-9568.2010.07348.x
Publikováno v:
The Journal of Biochemistry. 118:1239-1247
The N-terminal 28-residue peptide of actin whose Cys10 was labeled with 5-iodoacetamido-fluorescein (F3K peptide) was isolated from the fluorescently labeled thrombin digest of actin. The effect of myosin subfragment 1 (S1) on the fluorescence of F3K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::962d172d83d2eb840ff8ea69b1afbbca
https://doi.org/10.1093/oxfordjournals.jbchem.a125013
https://doi.org/10.1093/oxfordjournals.jbchem.a125013
Autor:
Shinji, Matsumura, Shunji, Kunori, Tamaki, Mabuchi, Tayo, Katano, Takanobu, Nakazawa, Tetsuya, Abe, Masahiko, Watanabe, Tadashi, Yamamoto, Emiko, Okuda-Ashitaka, Seiji, Ito
Publikováno v:
The European journal of neuroscience. 32(5)
Ca(2+) /calmodulin-dependent protein kinase II (CaMKII) is a key mediator of long-term potentiation (LTP), which can be triggered by N-methyl-d-aspartate (NMDA) receptor-mediated Ca(2+) influx. We previously demonstrated that Fyn kinase-mediated phos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9eed19f01c3617c9733878bfdfa4b02c
https://pubmed.ncbi.nlm.nih.gov/20722721
https://pubmed.ncbi.nlm.nih.gov/20722721
Autor:
Shinichi Tatsumi, Tamaki Mabuchi, Toshiaki Minami, Seiji Ito, Yukihiko Sugimoto, Shunji Kunori, Shinji Matsumura
Publikováno v:
Neuroscience. 163(1)
Nociceptive primary afferents have the capacity to induce a state of increased excitability in the dorsal horn neurons of the spinal cord. It is well accepted that capsaicin-sensitive C-fibers transduce noxious stimulation and acute pain and that cap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d18bc79623ee19fbc05b9b6a18a79b0
https://pubmed.ncbi.nlm.nih.gov/19490931
https://pubmed.ncbi.nlm.nih.gov/19490931