Zobrazeno 1 - 10
of 224
pro vyhledávání: '"Shunji, Kozaki"'
Autor:
Ryuji Kaji, Ai Miyashiro, Nori Sato, Taiki Furumoto, Toshiaki Takeuchi, Ryosuke Miyamoto, Tomoko Kohda, Yuishin Izumi, Shunji Kozaki
Publikováno v:
Toxins, Vol 14, Iss 11, p 739 (2022)
All the currently used type A botulinum neurotoxins for clinical uses are of subtype A1. We compared the efficacy and safety for the first time head-to-head between a novel botulinum toxin A2NTX prepared from subtype A2 and onabotulinumtoxinA (BOTOX)
Externí odkaz:
https://doaj.org/article/a8787929459748019040c3ac171f6cb7
Autor:
Toshiaki Takeuchi, Tsuyoshi Okuno, Ai Miyashiro, Tomoko Kohda, Ryosuke Miyamoto, Yuishin Izumi, Shunji Kozaki, Ryuji Kaji
Publikováno v:
Toxins, Vol 13, Iss 11, p 824 (2021)
All the botulinum type A neurotoxins available for clinical use are of the A1 subtype. We developed a subtype A2 low-molecular-weight (150 kD (kilo Dalton)) neurotoxin (A2NTX) with less spread and faster entry into the motor nerve terminal than A1 in
Externí odkaz:
https://doaj.org/article/9a9ff29f6a3843ac893cb75e843cbfad
Autor:
Min-Chul Shin, Masahito Wakita, Du-Jie Xie, Toshitaka Yamaga, Satomi Iwata, Yasushi Torii, Tetsuhiro Harakawa, Akihiro Ginnaga, Shunji Kozaki, Norio Akaike
Publikováno v:
Journal of Pharmacological Sciences, Vol 118, Iss 1, Pp 33-42 (2012)
Recent studies have demonstrated that the botulinum neurotoxins inhibit the release of acetylcholine, glutamate, GABA, and glycine in central nerve system (CNS) neurons. The Na+ current (INa) is of major interest because it acts as the trigger for ma
Externí odkaz:
https://doaj.org/article/62f5abd3ff5043848867d43c9a9733ca
Autor:
Yasushi Torii, Norio Akaike, Tetsuhiro Harakawa, Keiko Kato, Nakaba Sugimoto, Yoshitaka Goto, Shinji Nakahira, Tomoko Kohda, Shunji Kozaki, Ryuji Kaji, Akihiro Ginnaga
Publikováno v:
Journal of Pharmacological Sciences, Vol 117, Iss 4, Pp 275-285 (2011)
Abstract.: The adverse effects of botulinum LL toxin and neurotoxin produced by subtype A1 (A1LL and A1NTX) are becoming issues, as the toxins could diffuse from the toxin-treated (ipsilateral) to contralateral muscles. We have attempted to produce n
Externí odkaz:
https://doaj.org/article/78dbaae9ae104b128574f50ed372808d
Autor:
Yuishin Izumi, Ryosuke Miyamoto, Tsuyoshi Okuno, Ai Miyashiro, Shunji Kozaki, Ryuji Kaji, Tomoko Kohda, Toshiaki Takeuchi
Publikováno v:
Toxins, Vol 13, Iss 824, p 824 (2021)
Toxins
Toxins; Volume 13; Issue 11; Pages: 824
Toxins
Toxins; Volume 13; Issue 11; Pages: 824
All the botulinum type A neurotoxins available for clinical use are of the A1 subtype. We developed a subtype A2 low-molecular-weight (150 kD (kilo Dalton)) neurotoxin (A2NTX) with less spread and faster entry into the motor nerve terminal than A1 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fe3ac7c582b2c99680ddcc894fef8f0
https://www.mdpi.com/2072-6651/13/11/824
https://www.mdpi.com/2072-6651/13/11/824
Autor:
Shunji Kozaki, Toshiaki Takeuchi, Yuishin Izumi, Ryuji Kaji, Tomoko Kohda, Ryosuke Miyamoto, Tsuyoshi Okuno, Ai Miyashiro
All the available botulinum type A neurotoxins for clinical uses are of A1 subtype. We developed a subtype A2 low molecular weight (150kD) neurotoxin (A2NTX), with less spread and faster entry into the motor nerve terminal than A1 in vitro and in viv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bf453ef46a13632b716e46d5144079f
https://doi.org/10.20944/preprints202110.0121.v1
https://doi.org/10.20944/preprints202110.0121.v1
Autor:
Piyada Wangroongsarb, Tomoko Kohda, Chutima Jittaprasartsin, Karun Suthivarakom, Thanitchi Kamthalang, Kaoru Umeda, Pathom Sawanpanyalert, Shunji Kozaki, Kazuyoshi Ikuta
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e77792 (2014)
BACKGROUND: Thailand has had several foodborne outbreaks of botulism, one of the biggest being in 2006 when laboratory investigations identified the etiologic agent as Clostridium botulinum type A. Identification of the etiologic agent from outbreak
Externí odkaz:
https://doaj.org/article/d6f438f6eda740e292eee1bbd2997ee7
Publikováno v:
Microbiology and Immunology. 61:482-489
Clostridium botulinum produces the highly potent neurotoxin, botulinum neurotoxin (BoNT), which is classified into seven serotypes (A-G); the subtype classification is confirmed by the diversity of amino acid sequences among the serotypes. BoNT from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7e01e6ac4fefc0654a8817434aa26ff
https://doi.org/10.1111/1348-0421.12540
https://doi.org/10.1111/1348-0421.12540
Publikováno v:
Microbiology and immunologyREFERENCES. 64(7)
Botulinum neurotoxin (BoNT) is the causative agent of botulism in humans and animals. Only BoNT serotype A subtype 1 (BoNT/A1) is used clinically because of its high potency and long duration of action. BoNT/A1 and BoNT/A subtype 2 (BoNT/A2) have a h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2df31f246efd2d15c9ea98fb8b3a196
https://pubmed.ncbi.nlm.nih.gov/32301520
https://pubmed.ncbi.nlm.nih.gov/32301520
Autor:
Keiji Oguma, Masakiyo Sakaguchi, Tomonori Suzuki, Yoshihiko Sakaguchi, Yumiko Yamamoto, Tomoko Kohda, Shunji Kozaki, Shunji Hayashi, Jumpei Uchiyama, Akira Také, Koji Hosomi, Kazuyoshi Gotoh, Masafumi Mukamoto
Publikováno v:
Anaerobe. 66:102281
Clostridium argentinense produces botulinum neurotoxin type G (BoNT/G). We sequenced and analyzed the plasmid harboring the bont/G gene, designated pCAG, in C. argentinense strain 2740. The pCAG consisted of 140,070 bp containing the bont/G gene clus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d16a7b424c9507a96ea5b505e2e593
https://doi.org/10.1016/j.anaerobe.2020.102281
https://doi.org/10.1016/j.anaerobe.2020.102281