Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Shunichi Oya"'
Autor:
Andrei Molotkov, Patrick Carberry, Martin A. Dolan, Simon Joseph, Sidney Idumonyi, Shunichi Oya, John Castrillon, Elisa E. Konofagou, Mikhail Doubrovin, Glenn J. Lesser, Francesca Zanderigo, Akiva Mintz
Publikováno v:
Pharmaceutics, Vol 13, Iss 3, p 405 (2021)
Glioblastoma (GBM) is the most common primary adult brain malignancy with an extremely poor prognosis and a median survival of fewer than two years. A key reason for this high mortality is that the blood–brain barrier (BBB) significantly restricts
Externí odkaz:
https://doaj.org/article/e7a03a71ccb34b5b9dc1a3d520651608
Autor:
Ludovic Leriche, Thomas B. Cooper, Anissa Abi-Dargham, Agnès Montagne, Valérie Brunner, Simon Joseph, Marlène Guiraud, Florence Gaudoux, Patrick Carberry, Mark Slifstein, Chaitanya R. Divgi, Raymond F. Suckow, Pierre Sokoloff, Ragy R. Girgis, Françoise Tonner, Shunichi Oya
Publikováno v:
Psychopharmacology. 237:519-527
F17464, a dopamine D3 receptor antagonist with relatively high D3 selectivity (70 fold vs D2 in vitro), exhibits an antipsychotic profile in preclinical studies, and therapeutic efficacy was demonstrated in a randomized placebo-controlled clinical tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7f82ff674fc257a245221e943447376
https://doi.org/10.1007/s00213-019-05387-w
https://doi.org/10.1007/s00213-019-05387-w
Autor:
Mark, Slifstein, Anissa, Abi-Dargham, Ragy R, Girgis, Raymond F, Suckow, Thomas B, Cooper, Chaitanya R, Divgi, Pierre, Sokoloff, Ludovic, Leriche, Patrick, Carberry, Shunichi, Oya, Simon K, Joseph, Marlène, Guiraud, Agnès, Montagne, Valérie, Brunner, Florence, Gaudoux, Françoise, Tonner
Publikováno v:
Psychopharmacology. 237(2)
F17464, a dopamine D3 receptor antagonist with relatively high D3 selectivity (70 fold vs D2 in vitro), exhibits an antipsychotic profile in preclinical studies, and therapeutic efficacy was demonstrated in a randomized placebo-controlled clinical tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::daaba2ad04576f3a57ec70c3ddd92730
https://pubmed.ncbi.nlm.nih.gov/31773210
https://pubmed.ncbi.nlm.nih.gov/31773210
Autor:
John Castrillon, Francesca Zanderigo, Shunichi Oya, Akiva Mintz, Andrei Molotkov, Sidney Idumonyi, Mikhail Doubrovin, Elisa E. Konofagou, Glenn J. Lesser, Martin Dolan, Patrick Carberry, Simon Joseph
Publikováno v:
Pharmaceutics
Volume 13
Issue 3
Pharmaceutics, Vol 13, Iss 405, p 405 (2021)
Volume 13
Issue 3
Pharmaceutics, Vol 13, Iss 405, p 405 (2021)
Glioblastoma (GBM) is the most common primary adult brain malignancy with an extremely poor prognosis and a median survival of fewer than two years. A key reason for this high mortality is that the blood–brain barrier (BBB) significantly restricts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f471847df1611ebe0fff106a0da7bff4
https://doi.org/10.3390/pharmaceutics13030405
https://doi.org/10.3390/pharmaceutics13030405
Autor:
Wenchao, Qu, Shunichi, Oya, Brian P, Lieberman, Karl, Ploessl, Limin, Wang, David R, Wise, Chaitanya R, Divgi, Lewis A, Chodosh, Lewis P, Chodosh, Craig B, Thompson, Hank F, Kung
Publikováno v:
Journal of Nuclear Medicine. 53:98-105
Recently, there has been a renewed interest in the study of tumor metabolism above and beyond the Warburg effect. Studies on cancer cell metabolism have provided evidence that tumor-specific activation of signaling pathways, such as the upregulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2b53706e022689c9cadb03f9a3d5b4d
https://doi.org/10.2967/jnumed.111.093831
https://doi.org/10.2967/jnumed.111.093831
Publikováno v:
Nuclear Medicine and Biology. 37:577-586
Introduction Single photon emission computed tomography (SPECT) imaging of the serotonin transporter (SERT) in the brain is a useful tool for examining normal physiological functions and disease states involving the serotonergic system. The goal of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b22edcb90adcf640dba8e15fa2ae4681
https://doi.org/10.1016/j.nucmedbio.2010.02.010
https://doi.org/10.1016/j.nucmedbio.2010.02.010
Autor:
Catherine Hou, Brian P. Lieberman, Karl Ploessl, Hank F. Kung, Ajit K. Parhi, Julie L. Wang, Shunichi Oya
Publikováno v:
Nuclear Medicine and Biology. 37:479-486
Introduction The utility of [ 18 F]FPBM [2-(2′-((dimethylamino)methyl)-4′-(3-[ 18 F]-fluoropropoxy)phenylthio)benzenamine], a selective serotonin transporter (SERT) tracer, and [ 18 F]AV-133 [(+)-2-Hydroxy-3-isobutyl-9-(3-fluoropropoxy)-10-methox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abaf6f1c790946cdb1e8639628508b01
https://doi.org/10.1016/j.nucmedbio.2010.01.006
https://doi.org/10.1016/j.nucmedbio.2010.01.006
Autor:
Catherine Hou, Hank F. Kung, Daniel Skovronsky, Michael R. Kilbourn, Karl Poessl, Eric Blankemeyer, Brian P. Lieberman, Seok Rye Choi, Shunichi Oya, Mei-Ping Kung, Zhi Ping Zhuang
Publikováno v:
Nuclear Medicine and Biology. 35:825-837
Objectives Development of imaging agents for pancreatic beta cell mass may provide tools for studying insulin-secreting beta cells and their relationship with diabetes mellitus. In this paper, a new imaging agent, [ 18 F](+)-2-oxiranyl-3-isobutyl-9-(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5883dea7d92120ac78ab3a6a2e308db
https://doi.org/10.1016/j.nucmedbio.2008.08.004
https://doi.org/10.1016/j.nucmedbio.2008.08.004
Autor:
Catherine Hou, Mei-Ping Kung, Wei Zhang, Daniel Skovronsky, Rajesh Manchandra, Shunichi Oya, Zhi-Ping Zhuang, Hank F. Kung, Wenchao Qu, Seok-Rye Choi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4823-4827
Two new phenylacetylene derivatives, 5-((4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)phenyl)ethynyl)indoline 8 and 5-((4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)phenyl)ethynyl)-1 H -indole 14 , targeting β-amyloid (Aβ) plaques have been prepared. In vitro bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5cc3b9ab455bef55cb39aa1522c0167
https://doi.org/10.1016/j.bmcl.2008.07.077
https://doi.org/10.1016/j.bmcl.2008.07.077
Autor:
Hank F. Kung, Brian P. Lieberman, Catherine Hou, Michael R. Kilbourn, Daniel Skovronsky, Eric Blankemeyer, Shunichi Oya, Datta E. Ponde, Mei-Ping Kung
Publikováno v:
Journal of Nuclear Medicine. 49:1171-1176
Recent studies on gene expression of β-cell mass (BCM) in the pancreas showed that vesicular monoamine transporter 2 (VMAT2) is highly expressed in the BCM (mainly in the islets of Langerhans). Imaging pancreatic BCM may provide an important tool fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb0d1dfaccb0f05d808e6577da8c497d
https://doi.org/10.2967/jnumed.108.051680
https://doi.org/10.2967/jnumed.108.051680