Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Shunhui Wei"'
Autor:
Charlene P. Poore, Nurul A.M.N. Hazalin, Shunhui Wei, See Wee Low, Bo Chen, Bernd Nilius, Zurina Hassan, Ping Liao
Publikováno v:
Neurobiology of Disease, Vol 191, Iss , Pp 106408- (2024)
Excitotoxicity arises from unusually excessive activation of excitatory amino acid receptors such as glutamate receptors. Following an energy crisis, excitotoxicity is a major cause for neuronal death in neurological disorders. Many glutamate antagon
Externí odkaz:
https://doaj.org/article/0afdc4161e954daa850a94231c7a4c52
Autor:
Shunhui Wei, Julian Behn, Charlene Priscilla Poore, See Wee Low, Bernd Nilius, Hao Fan, Ping Liao
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Mouse monoclonal antibody M4M was recently designed to block human TRPM4 channel. The polypeptide for generating M4M is composed of peptide A1 between the transmembrane segment 5 (S5) and the pore, and a second peptide A2 between the pore an
Externí odkaz:
https://doaj.org/article/f6a643c7a2f442f3985610e499028acd
Autor:
Bo Chen, Shunhui Wei, See Wee Low, Charlene Priscilla Poore, Andy Thiam-Huat Lee, Bernd Nilius, Ping Liao
Publikováno v:
Biomedicines, Vol 11, Iss 5, p 1480 (2023)
Reperfusion therapy for acute ischemic stroke aims to restore the blood flow of occluded blood vessels. However, successful recanalization is often associated with disruption of the blood-brain barrier, leading to reperfusion injury. Delayed recanali
Externí odkaz:
https://doaj.org/article/8e4a42b0dd034554b1f8e22bf77dcef2
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract TRPM4 is a calcium-activated non-selective monovalent cation channel implicated in diseases such as stroke. Lack of potent and selective inhibitors remains a major challenge for studying TRPM4. Using a polypeptide from rat TRPM4, we have gen
Externí odkaz:
https://doaj.org/article/4e73928161fe44fea160522f5b96ca9b
Autor:
Shunhui Wei, See Wee Low, Charlene Priscilla Poore, Bo Chen, Yahui Gao, Bernd Nilius, Ping Liao
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
In stroke and other neurological diseases, Transient Receptor Potential Melastatin 4 (TRPM4) has been reported to cause oncotic cell death which is due to an excessive influx of sodium ions. Following stroke, hypoxia condition activates TRPM4 channel
Externí odkaz:
https://doaj.org/article/4b214e4019784ec6963c5bf2b9a08251
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports
TRPM4 is a calcium-activated non-selective monovalent cation channel implicated in diseases such as stroke. Lack of potent and selective inhibitors remains a major challenge for studying TRPM4. Using a polypeptide from rat TRPM4, we have generated a
Autor:
Shaoping Xie, Shunhui Wei, Mei-Chih Liao, Allen Chen, Shaul Reuveny, Steve Oh, Walter Hunziker, Li Zeng, Zhi Dong Zhou, Lifeng Qiu, Eng-King Tan
Publikováno v:
Stem Cells Translational Medicine
Recent reports have indicated human embryonic stem cells-derived midbrain dopamine (mDA) neurons as proper cell resources for use in Parkinson's disease (PD) therapy. Nevertheless, no detailed and systematic study has been conducted to identify which
Autor:
Tian Ming Tu, Ping Liao, See Wee Low, Bo Chen, Dejie Yu, Tuck Wah Soong, Bernd Nilius, Yahui Gao, Shunhui Wei, Gandi Ng
Publikováno v:
Pflugers Archiv
Reperfusion therapy is currently the gold standard treatment for acute ischemic stroke. However, reperfusion injuries such as oedema and haemorrhagic transformation largely limit the use of this potent treatment to a narrow time window. Recently, tra
Autor:
Andre Choo, Stanley Kwang-Loong Ng, Selena Meiyun Wu, Dong-Yup Lee, Thian Thian Beh, Shunhui Wei, Ker Sin Tan, Hock Chuan Yeo, Huishan Chen, Ken Kwok-Keung Chan
Publikováno v:
Stem Cells and Development. 21:729-741
Molecular and cellular signaling pathways are involved in the process of neural differentiation from human embryonic stem cells (hESC) to terminally differentiated neurons. The Sonic hedgehog (SHH) morphogen is required to direct the differentiation
Autor:
Chaminda Jayampath Seneviratne, Tong Cao, Mengfei Yu, Bjorn R. Olsen, Mingming Li, Huei Jinn Tong, Chuan Yan, Gopu Sriram, Qian Zhu, Qiqi Lu, Walter Hunziker, Rong Gao, Shunhui Wei, Yu Zou, Zhiyuan Gong
Publikováno v:
Biotechnology Journal. 12:1700067
Neural crest stem cells (NCSCs) are a transient and multipotent cell population giving rise to various cell types with clinical importance. Isolation of human NCSCs is extremely challenging that limits our knowledge about neural crest development and