Efficacy and Safety of Filgotinib in Patients with High Risk of Poor Prognosis Who Showed Inadequate Response to MTX: A Post Hoc Analysis of the FINCH 1 Study

Autor: Bernard G. Combe, Yoshiya Tanaka, Maya H. Buch, Peter Nash, Gerd R. Burmester, Alan J. Kivitz, Beatrix Bartok, Alena Pechonkina, Katrina Xia, Kahaku Emoto, Shungo Kano, Thijs K. Hendrikx, Robert B. M. Landewé, Daniel Aletaha

Publikováno v: Rheumatology and Therapy, Vol 10, Iss 1, Pp 53-70 (2022)

Abstract Introduction This exploratory analysis of FINCH 1 (NCT02889796) examined filgotinib (FIL) efficacy and safety in a subgroup of patients with rheumatoid arthritis (RA) and inadequate response to methotrexate (MTX; MTX-IR) who had four poor pr

Externí odkaz: https://doaj.org/article/d5f278750ece4369b8287f893aae3cee

Two lamprey Hedgehog genes share non-coding regulatory sequences and expression patterns with gnathostome Hedgehogs.

Autor: Shungo Kano, Jin-Hua Xiao, Joana Osório, Marc Ekker, Yavor Hadzhiev, Ferenc Müller, Didier Casane, Ghislaine Magdelenat, Sylvie Rétaux

Publikováno v: PLoS ONE, Vol 5, Iss 10, p e13332 (2010)

Hedgehog (Hh) genes play major roles in animal development and studies of their evolution, expression and function point to major differences among chordates. Here we focused on Hh genes in lampreys in order to characterize the evolution of Hh signal

Externí odkaz: https://doaj.org/article/bb2774d9136c4d0e988713db1630a391

Genomics and developmental approaches to an ascidian adenohypophysis primordium

Autor: Shungo Kano

Publikováno v: Integrative and comparative biology. 50(1)

Ascidians, which are the closest phylogenetic relatives to vertebrates, lack a distinct pituitary gland, which is the major endocrine gland in vertebrates. Nevertheless, for the past 130 years, it has been debated that the ascidian neural complex (NC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f19e7c02145474ba1b6542621619358a
https://pubmed.ncbi.nlm.nih.gov/21558186

Windows of the brain: Towards a developmental biology of circumventricular and other neurohemal organs

Autor: Alessandro Alunni, Sylvie Rétaux, Jean-Stéphane Joly, Shungo Kano, Hélène Auger, Joana Osório

Publikováno v: Seminars in Cell and Developmental Biology
Seminars in Cell and Developmental Biology, Elsevier, 2007, 18 (4), pp.512-524. ⟨10.1016/j.semcdb.2007.06.001⟩
Seminars in Cell and Developmental Biology, Elsevier, 2007, 18 (4), pp.512-524

We review the anatomical and functional features of circumventricular organs in vertebrates and their homologous neurohemal organs in invertebrates. Focusing on cyclostomes (lamprey) and urochordates (ascidians), we discuss the evolutionary origin of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97006f0bef98dc814e0661fead51ca1e
https://hal.archives-ouvertes.fr/hal-00174658

Initial stage of genetic mapping in Ciona intestinalis

Autor: Shungo Kano

Publikováno v: Developmental Dynamics
Developmental Dynamics, Wiley, 2007, 236 (7), pp.1768-81. ⟨10.1002/dvdy.21163⟩

The use of classic genetics is emerging in the ascidian Ciona intestinalis; recent advances in genomics and high-quality developmental and evolutionary studies have made this animal an attractive model for research purposes. Genetic mapping in Ciona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fdab68ab2d26381370a79d4ba43a82b
https://pubmed.ncbi.nlm.nih.gov/17471502