Scalable production of siRNA‐encapsulated extracellular vesicles for the inhibition of KRAS‐mutant cancer using acoustic shock waves

Autor: Hyo Kyeong Kim, Yujeong Choi, Kyoung Hwa Kim, Yeongju Byun, Tae Hee Kim, Jae Hwan Kim, Shung Hyun An, DaeHo Bae, Myeong Kwan Choi, Minyoung Lee, Gwansuk Kang, Jihwa Chung, Seok‐Hyun Kim, Kihwan Kwon

Publikováno v: Journal of Extracellular Vesicles, Vol 13, Iss 9, Pp n/a-n/a (2024)

Abstract Extracellular vesicles (EVs) have emerged as a potential delivery vehicle for nucleic‐acid‐based therapeutics, but challenges related to their large‐scale production and cargo‐loading efficiency have limited their therapeutic potenti

Externí odkaz: https://doaj.org/article/9ae6fb533aaf4b39a59699e3053e8639

Ursodeoxycholic Acid (UDCA) Exerts Anti-Atherogenic Effects by Inhibiting RAGE Signaling in Diabetic Atherosclerosis.

Autor: Jihwa Chung, Shung Hyun An, Sang Won Kang, Kihwan Kwon

Publikováno v: PLoS ONE, Vol 11, Iss 1, p e0147839 (2016)

A naturally occurring bile acid, ursodeoxycholic acid (UDCA), is known to alleviate endoplasmic reticulum (ER) stress at the cellular level. However, the detailed action mechanisms of UDCA in atherosclerosis are not fully understood. In this study, w

Externí odkaz: https://doaj.org/article/b5033fe106714fd88f8cb337c188117f

Fluid shear stress regulates the expression of Lectin-like oxidized low density lipoprotein receptor-1 via KLF2-AP-1 pathway depending on its intensity and pattern in endothelial cells

Autor: Lee, Ji Yoon, Chung, Jihwa, Kim, Kyoung Hwa, An, Shung Hyun, Kim, Minsuk, Park, Junbeom, Kwon, Kihwan

Publikováno v: In Atherosclerosis March 2018 270:76-88

Fluid Shear Stress Regulates the Landscape of microRNAs in Endothelial Cell-Derived Small Extracellular Vesicles and Modulates the Function of Endothelial Cells

Autor: Jihwa Chung, Kyoung Hwa Kim, Namhee Yu, Shung Hyun An, Sanghyuk Lee, Kihwan Kwon

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1314
International Journal of Molecular Sciences, Vol 23, Iss 1314, p 1314 (2022)

Blood fluid shear stress (FSS) modulates endothelial function and vascular pathophysiology. The small extracellular vesicles (sEVs) such as exosomes are potent mediators of intercellular communication, and their contents reflect cellular stress. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08c7916870a490000abb8fabd3f811d3
https://pubmed.ncbi.nlm.nih.gov/35163238

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