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Akademický článek

Decreased DNA methylation in the promoter region of the WNT5A and GDNF genes may promote the osteogenicity of mesenchymal stem cells from patients with ossified spinal ligaments

Autor: Noriyuki Chiba, Ken-Ichi Furukawa, Shohei Takayama, Toru Asari, Shunfu Chin, Yoshifumi Harada, Gentaro Kumagai, Kanichiro Wada, Toshihiro Tanaka, Atsushi Ono, Shigeru Motomura, Manabu Murakami, Yasuyuki Ishibashi

Publikováno v: Journal of Pharmacological Sciences, Vol 127, Iss 4, Pp 467-473 (2015)

Mesenchymal stem cells (MSCs) isolated from spinal ligaments with ectopic ossification have a propensity toward the osteogenic lineage. To explore epigenetic control of the osteogenic features of MSCs, we treated MSCs obtained from the spinal ligamen

Externí odkaz: https://doaj.org/article/5d318038e0e24ae4aba75945e29bc1c0

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Facilitation of Chemotaxis Activity of Mesenchymal Stem Cells via Stromal Cell–Derived Factor-1 and Its Receptor May Promote Ectopic Ossification of Human Spinal Ligaments

Autor: Shigeru Motomura, Yasuyuki Ishibashi, Keigo Kurotaki, Shunpei Nagasaki, Ken-Ichi Furukawa, Gentaro Kumagai, Kanichiro Wada, Shunfu Chin

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 369:1-8

Mesenchymal stem cells (MSCs) have been used to elucidate the pathogenesis of numerous diseases. Our recent study showed that MSCs may conduce to the ossification of spinal ligaments. Stromal cell-derived factor-1 (SDF-1) and CXC chemokine receptor 4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fc2c95b33f42e7e27ff54c481ba782c
https://doi.org/10.1124/jpet.118.254367

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Ectopic Ossification of Human Spinal Ligaments Caused by Mesenchymal Stem Cell Abnormalities

Autor: Yasuyuki Ishibashi, Shunfu Chin, Ken-Ichi Furukawa, Kanichiro Wada, Gentaro Kumagai, Toru Asari

Publikováno v: OPLL ISBN: 9789811538544

Ectopic ossification of the spinal ligament and its progression compresses the spinal cord, resulting in serious neurological deficiencies. Surgery is an established therapy that has had considerable success, but it is often associated with a higher

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d367e80cbcfba20cf15d7b826630a74
https://doi.org/10.1007/978-981-15-3855-1_7

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Decreased DNA methylation in the promoter region of the WNT5A and GDNF genes may promote the osteogenicity of mesenchymal stem cells from patients with ossified spinal ligaments

Autor: Toshihiro Tanaka, Atsushi Ono, Gentaro Kumagai, Kanichiro Wada, Ken-Ichi Furukawa, Shohei Takayama, Toru Asari, Yasuyuki Ishibashi, Noriyuki Chiba, Manabu Murakami, Yoshifumi Harada, Shigeru Motomura, Shunfu Chin

Publikováno v: Journal of Pharmacological Sciences, Vol 127, Iss 4, Pp 467-473 (2015)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f58d64028f07d5715924d63bc5c5174
http://www.sciencedirect.com/science/article/pii/S1347861315000705

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Osteogenic lineage commitment of mesenchymal stem cells from patients with ossification of the posterior longitudinal ligament

Autor: Toshihiro Tanaka, Shigeru Motomura, Soroku Yagihashi, Manabu Murakami, Toru Asari, Shunfu Chin, Atsushi Ono, Yasuyuki Ishibashi, Ken-Ichi Furukawa, Hiroki Mizukami, Yoshifumi Harada

Publikováno v: Biochemical and Biophysical Research Communications. 443:1014-1020

Ectopic bone formation is thought to be responsible for ossification of the posterior longitudinal ligament of the spine (OPLL). Mesenchymal stem cells (MSCs) were isolated from spinal ligaments and shown to play a key role in the process of ectopic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d866c89b21f4c57ff3636c18a1acb065
https://doi.org/10.1016/j.bbrc.2013.12.080

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K-line (-) in the Neck-Flexed Position in Patients With Ossification of the Posterior Longitudinal Ligament Is a Risk Factor for Poor Clinical Outcome After Cervical Laminoplasty

Autor: Hitoshi Kudo, Shunfu Chin, Toru Yokoyama, Kanichiro Wada, Takuya Numasawa, Yoshihito Yamasaki, Taito Itabashi, Kazunari Takeuchi

Publikováno v: Spine. 41(24)

Study design Retrospective study comparing postoperative clinical outcomes after cervical laminoplasty between K-line (-) ossification of the posterior longitudinal ligament (OPLL) and K-line (+) OPLL in the neck-flexed position. Objective To investi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d7787a29a570025f50f34ecbdd0ad50
https://pubmed.ncbi.nlm.nih.gov/27120063

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