Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Shun-Ichiro Komatsu"'
Autor:
Shun-ichiro Komatsu, Yoko Kayukawa, Yoko Miyazaki, Akihisa Kaneko, Hisashi Ikegami, Takahiro Ishiguro, Mikiko Nakamura, Werner Frings, Natsuki Ono, Kiyoaki Sakata, Toshihiko Fujii, Shohei Kishishita, Takehisa Kitazawa, Mika Endo, Yuji Sano
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Currently, ERY974, a humanized IgG4 bispecific T cell-redirecting antibody recognizing glypican-3 and CD3, is in phase I clinical trials. After a first-in-human clinical trial of an anti-CD28 agonist monoclonal antibody resulting in severe l
Externí odkaz:
https://doaj.org/article/d2beb88677cc4be395bfc5abeda0d963
Autor:
Nozomi FUJISAWA, Tomochika MATSUSHITA, Saori MATSUO, Mayumi HIRANUMA, Hiroko AZABU, Ryota SAITO, Shun-Ichiro KOMATSU, Atsuhiko KATO, Naoto TOYOTA, Junko TAKETO, Hiromi SUZUKI
Publikováno v:
Experimental Animals; 2024, Vol. 73 Issue 1, p73-82, 10p
Autor:
Tomoyuki Igawa, Takehisa Kitazawa, Yoshiki Kawabe, Kou-ichi Jishage, Mika Endo, Yoshito Nakanishi, Otoya Ueda, Atsuhiko Kato, Noriaki Sawada, Yasushi Tomii, Fumihisa Isomura, Masaki Kamimura, Tetsuya Wakabayashi, Ami Ito, Haruka Kuroi, Junko Shinozuka, Yuki Noguchi, Motohiko Sato, Yasuko Satoh, Nasa Savory, Sotaro Naoi, Koki Hamada, Ayano Hirako, Sayuri Horikawa, Akihisa Sakamoto, Shun-ichiro Komatsu, Shojiro Kadono, Tomochika Matsushita, Tetsushi Sakiyama, Kenji Adachi, Natsuki Ono, Tatsuhiko Tachibana, Hirofumi Mikami, Shun Shimizu, Yuki Ohte, Naoko A. Wada, Taro Miyazaki, Shoichi Metsugi, Meiri Shida-Kawazoe, Kenji Taniguchi, Naoka Hironiwa, Masaki Honda, Ryo Uchikawa, Takayuki Nemoto, Yuji Hori, Yoshinori Narita, Mika Kamata-Sakurai
Supplementary figures, tables, material and methods, and references
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ef075e9b136326aba4e8a3303859f52
https://doi.org/10.1158/2159-8290.22535753.v1
https://doi.org/10.1158/2159-8290.22535753.v1
Autor:
Yuri Teranishi-Ikawa, Tetsuhiro Soeda, Hikaru Koga, Kazuki Yamaguchi, Kazuki Kato, Keiko Esaki, Kentaro Asanuma, Miho Funaki, Mina Ichiki, Yuri Ikuta, Shunsuke Ito, Eri Joyashiki, Shun-Ichiro Komatsu, Atsushi Muto, Kei Nishimura, Momoko Okuda, Hisakazu Sanada, Motohiko Sato, Norihito Shibahara, Tetsuya Wakabayashi, Koji Yamaguchi, Akiko Matsusaki, Zenjiro Sampei, Hirotake Shiraiwa, Hiroko Konishi, Yoshiki Kawabe, Kunihiro Hattori, Takehisa Kitazawa, Tomoyuki Igawa
Emicizumab, a factor (F)VIIIa-function mimetic bispecific antibody (BsAb) to FIXa and FX, has become an indispensable treatment for people with hemophilia A (PwHA). Although emicizumab is very potent, long-term outcomes from the clinical studies sugg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65e05c434bee4d4affb01dcc8f26f39e
https://doi.org/10.1101/2022.12.19.520692
https://doi.org/10.1101/2022.12.19.520692
Autor:
Tatsuhiko Tachibana, Nasa Savory, Otoya Ueda, Sayuri Horikawa, Tetsushi Sakiyama, Tomochika Matsushita, Yuji Hori, Kou-ichi Jishage, Haruka Kuroi, Motohiko Sato, Tetsuya Wakabayashi, Junko Shinozuka, Naoka Hironiwa, Meiri Shida-Kawazoe, Kenji Adachi, Ryo Uchikawa, Taro Miyazaki, Koki Hamada, Masaki Honda, Fumihisa Isomura, Mika Endo, Mika Kamata-Sakurai, Yoshito Nakanishi, Yuki Noguchi, Natsuki Ono, Yasuko Satoh, Yuki Ohte, Tomoyuki Igawa, Ayano Hirako, Hirofumi Mikami, Naoko A. Wada, Noriaki Sawada, Takehisa Kitazawa, Yasushi Tomii, Shun-ichiro Komatsu, Takayuki Nemoto, Yoshinori Narita, Kenji Taniguchi, Shun Shimizu, Naoi Sotaro, Akihisa Sakamoto, Shojiro Kadono, Yoshiki Kawabe, Atsuhiko Kato, Kamimura Masaki, Shoichi Metsugi, Ami Ito
Publikováno v:
Cancer Discovery. 11:158-175
Agonistic antibodies targeting CD137 have been clinically unsuccessful due to systemic toxicity. Because conferring tumor selectivity through tumor-associated antigen limits its clinical use to cancers that highly express such antigens, we exploited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a70e3edd07d12527043287be739925bc
https://doi.org/10.1158/2159-8290.cd-20-0328
https://doi.org/10.1158/2159-8290.cd-20-0328
Autor:
Takahiro Ishiguro, Werner Frings, Yuji Sano, Akihisa Kaneko, Jun-ichi Nezu, Yasuko Kinoshita, Yoko Kayukawa, Toshiaki Tsunenari, Mika Endo, Yumiko Azuma, Shun-ichiro Komatsu, Natsuki Ono, Mika Kamata-Sakurai, Hirotake Shiraiwa
Publikováno v:
Cancer Research. 76:DDT01-05
Immune checkpoint inhibitors such as anti-PD1 antibodies have shown promising clinical responses in several solid tumors, however there remain patients who do not show an adequate response. Recent biomarker studies have revealed that the presence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9d927cc91be1499a3c7e08f7c981384
https://doi.org/10.1158/1538-7445.am2016-ddt01-05
https://doi.org/10.1158/1538-7445.am2016-ddt01-05
Autor:
Hitoshi Yoshino, Shunsuke Nagao, Yoshiyuki Suzuki, Masanori Fukazawa, Shun-ichiro Komatsu, Kotaro Ogawa, Yoshiki Kawabe, Takahiro Kawai, Fumihito Tanino
Publikováno v:
Diabetes. 67
Activation of glucagon-like peptide-1 receptors (GLP-1R) is a promising approach for the treatment of type 2 diabetes mellitus (T2D), and several peptide analogues of GLP-1 have been successfully developed. Here we identified a new orally active non-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4642b8d8ec93eaf0314e43fa82059eb
https://doi.org/10.2337/db18-1118-p
https://doi.org/10.2337/db18-1118-p
Autor:
Tomoyuki Igawa, Hiroko Konishi, Shuichi Chiba, Yukari Nishito, Etsuko Fujii, Hiroaki Segawa, Toshiaki Tsunenari, Atsushi Narita, Asako Harada, Takashi Tsushima, Hirotake Shiraiwa, Kunihiro Hattori, Eitaro Nanba, Ehab Elgabry, Akihisa Kaneko, Mizuho Noguchi, Lorraine Stewart, Masahiro Aoki, Mika Endo, Hironori Mutoh, Yuji Sano, Jun-ichi Nezu, Yukiko Sonobe, Yoshiki Kawabe, Yumiko Azuma, Shun-ichiro Komatsu, Tetsuya Wakabayashi, Akihisa Sakamoto, Natsuki Ono, Yoko Kayukawa, Kiyoaki Sakata, Yasuko Kinoshita, Yoko Miyazaki, Toshihiko Fujii, Masaki Ishigai, Mika Kamata-Sakurai, Mina Takahashi, Takahiro Ishiguro, Werner Frings
Publikováno v:
Science translational medicine. 9(410)
Cancer care is being revolutionized by immunotherapies such as immune checkpoint inhibitors, engineered T cell transfer, and cell vaccines. The bispecific T cell-redirecting antibody (TRAB) is one such promising immunotherapy, which can redirect T ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d23ef2e133f7bf3257b30ef5449c80b
https://pubmed.ncbi.nlm.nih.gov/29147028
https://pubmed.ncbi.nlm.nih.gov/29147028
Autor:
Etsuko Fujii, Kentaro Asanuma, Atsuhiko Kato, Kenji Adachi, Tetsuro Sugimoto, Shun-ichiro Komatsu, Kaori Isobe, Chie Kato, Tsuneo Ito, Masami Suzuki
Publikováno v:
Journal of Toxicologic Pathology
Increased incidence of adrenal pheochromocytoma is frequently encountered in rat carcinogenicity studies. In some of the studies, the finding is judged to be due to a rat-specific mechanism of carcinogenesis caused by a disturbance of calcium homeost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc1e059e1be3e176234550b6f476c5d
https://doi.org/10.1293/tox.25.281
https://doi.org/10.1293/tox.25.281
TOTAL PARENTERAL NUTRITION USING CONTINUOUS INTRAVENOUS INFUSION VIA THE POSTERIOR VENA CAVA IN RATS
Publikováno v:
The Journal of Toxicological Sciences. 31:139-147
This study was conducted to evaluate the feasibility of total parenteral nutrition (TPN) in rats using continuous intravenous infusion (tail cuff method) via the posterior vena cava. A catheter was inserted into the posterior vena cava from the femor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0e10ebb741ced390af5ab964ae822f6
https://doi.org/10.2131/jts.31.139
https://doi.org/10.2131/jts.31.139