Výsledky vyhledávání - "Shun-Ichi Sekine"

Akademický článek

Structural basis of eukaryotic transcription termination by the Rat1 exonuclease complex

Autor: Tatsuo Yanagisawa, Yuko Murayama, Haruhiko Ehara, Mie Goto, Mari Aoki, Shun-ichi Sekine

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)

Abstract The 5´–3´ exoribonuclease Rat1/Xrn2 is responsible for the termination of eukaryotic mRNA transcription by RNAPII. Rat1 forms a complex with its partner proteins, Rai1 and Rtt103, and acts as a “torpedo” to bind transcribing RNAPII a

Externí odkaz: https://doaj.org/article/1d8258503a644759ac0117a443409231

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Akademický článek

NMR Studies of Genomic RNA in 3′ Untranslated Region Unveil Pseudoknot Structure that Initiates Viral RNA Replication in SARS-CoV‑2

Autor: Takako Ohyama, Takuo Osawa, Shun-ichi Sekine, Yoshitaka Ishii

Publikováno v: JACS Au, Vol 4, Iss 4, Pp 1323-1333 (2024)

Externí odkaz: https://doaj.org/article/e8b9c6f97c014e32a6daf0c6fb0dfbc4

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Akademický článek

ERK2-topoisomerase II regulatory axis is important for gene activation in immediate early genes

Autor: Heeyoun Bunch, Deukyeong Kim, Masahiro Naganuma, Reiko Nakagawa, Anh Cong, Jaehyeon Jeong, Haruhiko Ehara, Hongha Vu, Jeong Ho Chang, Matthew J. Schellenberg, Shun-ichi Sekine

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Abstract The function of the mitogen-activated protein kinase signaling pathway is required for the activation of immediate early genes (IEGs), including EGR1 and FOS, for cell growth and proliferation. Recent studies have identified topoisomerase II

Externí odkaz: https://doaj.org/article/49c9e9c6f84e4989b8496e6edec3c70a

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Akademický článek

Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H1

Autor: Rina Hirano, Haruhiko Ehara, Tomoya Kujirai, Tamami Uejima, Yoshimasa Takizawa, Shun-ichi Sekine, Hitoshi Kurumizaka

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)

The mechanism by which RNAPII transcribes the DNA in the chromatosome with H1 has remained enigmatic. Here the authors present the cryo-EM structures of the RNAPII-chromatosome complexes, and explain how RNAPII is regulated by H1 in chromatin.

Externí odkaz: https://doaj.org/article/5e9682fe85694f7a96b35df8cc360283

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Akademický článek

Structural Transition of the Nucleosome during Transcription Elongation

Autor: Tomoya Kujirai, Haruhiko Ehara, Shun-ichi Sekine, Hitoshi Kurumizaka

Publikováno v: Cells, Vol 12, Iss 10, p 1388 (2023)

In eukaryotes, genomic DNA is tightly wrapped in chromatin. The nucleosome is a basic unit of chromatin, but acts as a barrier to transcription. To overcome this impediment, the RNA polymerase II elongation complex disassembles the nucleosome during

Externí odkaz: https://doaj.org/article/721bb27f5fdc436bb19f7346e99b5432

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Akademický článek

Reverse mutants of the catalytic 19 kDa mutant protein (nanoKAZ/nanoLuc) from Oplophorus luciferase with coelenterazine as preferred substrate

Autor: Satoshi Inouye, Jun-ichi Sato, Yuiko Sahara-Miura, Yuri Tomabechi, Yuto Sumida, Shun-ichi Sekine, Mikako Shirouzu, Takamitsu Hosoya

Publikováno v: PLoS ONE, Vol 17, Iss 9 (2022)

Native Oplophorus luciferase (OpLase) and its catalytic 19 kDa protein (wild KAZ) show highest luminescence activity with coelenterazine (CTZ) among CTZ analogs. Mutated wild KAZ with 16 amino acid substitutions (nanoKAZ/nanoLuc) utilizes bis-coelent

Externí odkaz: https://doaj.org/article/0ab9804ceac14a5fa5afb2bd5e36d483

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Akademický článek

Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase.

Autor: Hideaki Shimizu, Akatsuki Saito, Junko Mikuni, Emi E Nakayama, Hiroo Koyama, Teruki Honma, Mikako Shirouzu, Shun-Ichi Sekine, Tatsuo Shioda

Publikováno v: PLoS Neglected Tropical Diseases, Vol 13, Iss 11, p e0007894 (2019)

Dengue is a mosquito-borne viral infection that has spread globally in recent years. Around half of the world's population, especially in the tropics and subtropics, is at risk of infection. Every year, 50-100 million clinical cases are reported, and

Externí odkaz: https://doaj.org/article/43f267c34fa24a76ac3ed80987f0f2ce

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