Zobrazeno 1 - 10
of 203
pro vyhledávání: '"Shun-Hua Chen"'
Autor:
Po-Jen Chen, Shun-Hua Chen, Yu-Li Chen, Yi-Hsuan Wang, Cheng-Yu Lin, Chun-Hong Chen, Yung-Fong Tsai, Tsong-Long Hwang
Publikováno v:
Journal of Advanced Research, Vol 62, Iss , Pp 229-243 (2024)
Introduction: Overwhelming neutrophil activation and oxidative stress significantly contribute to acute respiratory distress syndrome (ARDS) pathogenesis. However, the potential of repurposing ribociclib, a cyclin-dependent kinase 4 and 6 (CDK4/6) in
Externí odkaz:
https://doaj.org/article/253e57a5843748d2a16b88013cc43780
Autor:
Ya-Li Hu, Shin-Yu Lin, Chien-Nan Lee, Jin-Chung Shih, Ai-Ling Cheng, Shun-Hua Chen, Luan-Yin Chang, Chi-Tai Fang
Publikováno v:
Journal of Microbiology, Immunology and Infection, Vol 56, Iss 4, Pp 766-771 (2023)
Background: Maternal transplacental antibody is an important origins of passive immunity against neonatal enterovirus infection. Echovirus 11 (E11) and coxsackievirus B3 (CVB3) are important types causing neonatal infections. There were few investiga
Externí odkaz:
https://doaj.org/article/11f950baa5684e12b6057074ed41792d
Autor:
Yu-Jheng Lin, Li-Chiu Wang, Huey-Pin Tsai, Chia-Yu Chi, Chih-Peng Chang, Shun-Hua Chen, Shih-Min Wang
Publikováno v:
Virus Research, Vol 336, Iss , Pp 199203- (2023)
Fulminant hepatitis is a life-threatening complication of coxsackievirus B (CVB) 3 infections. The condition may deteriorate to disseminated intravascular coagulopathy with markedly increased liver enzymes, inflammatory cytokines, and chemokines, whi
Externí odkaz:
https://doaj.org/article/4f0d40ff528a4308a42630dbe16e0ec6
Autor:
Meng-Shan Tsai, Li-Chiu Wang, Hua-Lin Wu, Shun-Fen Tzeng, Edward M. Conway, Sheng-Min Hsu, Shun-Hua Chen
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-18 (2022)
Abstract Background Herpes simplex virus 1 (HSV-1) can induce fatal encephalitis. Cellular factors regulate the host immunity to affect the severity of HSV-1 encephalitis. Recent reports focus on the significance of thrombomodulin (TM), especially th
Externí odkaz:
https://doaj.org/article/46f73e80a69e4173ac1ac52aedab6d5f
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Neonatal infection with nonpolio enteroviruses (EVs) causes nonspecific febrile illnesses and even life-threatening multiorgan failure. Hepatitis, which often results in hepatic necrosis followed by disseminated intravascular coagulopathy, is one of
Externí odkaz:
https://doaj.org/article/31904e56fdd54faaa091e8364bfc5af6
Autor:
Li-Chiu Wang, Shang-Rung Wu, Hui-Wen Yao, Pin Ling, Guey-Chuen Perng, Yen-Chi Chiu, Sheng-Min Hsu, Shun-Hua Chen
Publikováno v:
PLoS Pathogens, Vol 18, Iss 8, p e1010692 (2022)
Herpes simplex virus 1 (HSV-1)-induced encephalitis is the most common cause of sporadic, fatal encephalitis in humans. HSV-1 has at least 10 different envelope glycoproteins, which can promote virus infection. The ligands for most of the envelope gl
Externí odkaz:
https://doaj.org/article/e96f342f5b294d91904824a74f09624d
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Histone modifications control the lytic gene expression of herpes simplex virus 1 (HSV-1). The heterochromatin mark, trimethylation of histone H3 on lysine (K) 9 (H3K9me3), is detected on HSV-1 genomes at early phases of infection to repress viral ge
Externí odkaz:
https://doaj.org/article/307454ef0b7e4445beb082bfb5f26e82
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The activation of the sympathetic nervous system, release of norepinephrine (NE), and adrenergic receptor signaling participate in and regulate the complicated enterovirus 71 (EV71) brainstem encephalitis (BE). The neurotoxin 6-hydroxydopamine (6-OHD
Externí odkaz:
https://doaj.org/article/7883dc169e4c461fbd7d3bdf5ca909d3
Autor:
Shun-Hua Chen, Angel Chao, Chia-Lung Tsai, Shih-Che Sue, Chiao-Yun Lin, Yi-Zong Lee, Yi-Lin Hung, An-Shine Chao, Ann-Joy Cheng, Hsin-Shih Wang, Tzu-Hao Wang
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss , Pp 99-111 (2019)
The delivery of active proteins into cells (protein transfection) for biological purposes offers considerable potential for clinical applications. Herein we demonstrate that, with a readily available, inexpensive organic agent, the 4-(2-hydroxyethyl)
Externí odkaz:
https://doaj.org/article/a563e8e1077742e085b45eece36fcd36
Autor:
Sarah S. Darwish, Po-Jen Chen, Mostafa M. Hamed, Reem A. Wagdy, Shun-Hua Chen, Ashraf H. Abadi, Mohammad Abdel-Halim, Tsong-Long Hwang, Matthias Engel
Publikováno v:
Pharmaceuticals, Vol 15, Iss 7, p 778 (2022)
For many inflammatory diseases, new effective drugs with fewer side effects are needed. While it appears promising to target the activation of the central pro-inflammatory transcription factor NF-κB, many previously discovered agents suffered from c
Externí odkaz:
https://doaj.org/article/4f94eed140294a279c7ecbceba04a02c