Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Shun Xie Teo"'
Autor:
Slim Mzoughi, Jia Yi Fong, David Papadopoli, Cheryl M. Koh, Laura Hulea, Paolo Pigini, Federico Di Tullio, Giuseppe Andreacchio, Michal Marek Hoppe, Heike Wollmann, Diana Low, Matias J. Caldez, Yanfen Peng, Denis Torre, Julia N. Zhao, Oro Uchenunu, Gabriele Varano, Corina-Mihaela Motofeanu, Manikandan Lakshmanan, Shun Xie Teo, Cheng Mun Wun, Giovanni Perini, Soo Yong Tan, Chee Bing Ong, Muthafar Al-Haddawi, Ravisankar Rajarethinam, Susan Swee-Shan Hue, Soon Thye Lim, Choon Kiat Ong, Dachuan Huang, Siok-Bian Ng, Emily Bernstein, Dan Hasson, Keng Boon Wee, Philipp Kaldis, Anand Jeyasekharan, David Dominguez-sola, Ivan Topisirovic, Ernesto Guccione
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The transcriptional regulator PRDM15 is expressed at low levels in normal tissues but overexpressed in B-cell lymphomas. Here, the authors show that PRDM15 depletion does not affect adult somatic cell homeostasis but leads to a metabolic crisis which
Externí odkaz:
https://doaj.org/article/9df5fd5400ec47e98903d3b9c0b42cbb
Autor:
Antonella Scaglione, Julia Patzig, Jialiang Liang, Rebecca Frawley, Jabez Bok, Angeliki Mela, Camila Yattah, Jingxian Zhang, Shun Xie Teo, Ting Zhou, Shuibing Chen, Emily Bernstein, Peter Canoll, Ernesto Guccione, Patrizia Casaccia
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Myelin-forming cells derive from oligodendrocyte progenitors. Here the authors identify histone arginine methyl-transferase PRMT5 as critical for developmental myelination by modulating the cross-talk between histone arginine methylation and lysine a
Externí odkaz:
https://doaj.org/article/76b30499e5d34bdbba4aa57b8416de06
Autor:
Heike Wollmann, David Papadopoli, Ravisankar Rajarethinam, Giovanni Perini, Michal Marek Hoppe, Laura Hulea, Soo Yong Tan, Emily Bernstein, Susan Swee Shan Hue, Choon Kiat Ong, Siok Bian Ng, Soon Thye Lim, Slim Mzoughi, Cheryl M. Koh, Ivan Topisirovic, Federico Di Tullio, Manikandan Lakshmanan, Corina Mihaela Motofeanu, Ernesto Guccione, Cheng Mun Wun, Oro Uchenunu, Chee Bing Ong, David Dominguez-Sola, Shun Xie Teo, Diana Low, Giuseppe Andreacchio, Gabriele Varano, Dachuan Huang, Muthafar Al-Haddawi, Paolo Pigini, Denis Torre, Y Peng, Anand D. Jeyasekharan, Julia N. Zhao, Philipp Kaldis, Jia Yi Fong, Matias J. Caldez, Keng Boon Wee, Dan Hasson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
PRDM (PRDI-BF1 and RIZ homology domain containing) family members are sequence-specific transcriptional regulators involved in cell identity and fate determination, often dysregulated in cancer. The PRDM15 gene is of particular interest, given its lo
Autor:
Patrizia Casaccia, Julia Patzig, Shun Xie Teo, Shuibing Chen, Ting Zhou, Angeliki Mela, Emily Bernstein, Peter Canoll, Jingxian Zhang, Ernesto Guccione, Antonella Scaglione, Jialiang Liang, Camila Yattah, Jabez Bok, Rebecca Frawley
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications
Nature Communications
Oligodendrocytes (OLs) are the myelin-forming cells of the central nervous system. They are derived from differentiation of oligodendrocyte progenitors through a process requiring cell cycle exit and histone modifications. Here we identify the histon
Autor:
Delphine Hequet, N. Ray Dunn, Colin L. Stewart, Yuin-Han Loh, Jingxian Zhang, Heike Wollmann, Haitong Fang, Vinay Tergaonkar, Ernesto Guccione, Daniel M. Messerschmidt, Slim Mzoughi, Michelle K. Y. Seah, Qiao Rui Xing, Eun Myoung Shin, Sheena Li Ming Ong, Shun Xie Teo, Esther Sook Miin Wong, Marco Bezzi, Muthafar Al-Haddawi
Publikováno v:
Nature Genetics. 49:1354-1363
Ernesto Guccione and colleagues report that the transcription factor PRDM15 regulates naive pluripotency in mouse embryos and embryonic stem cells and in derivation of mouse and human iPSCs. They further show that PRDM15 promotes WNT signaling and in
Autor:
Zahid Quyoom Bonday, Julius Muller, Leah A. Vardy, Marco Bezzi, Shun Xie Teo, Wei Chuen Mok, Ernesto Guccione, Sanjeeb Kumar Sahu
Publikováno v:
Genes & Development. 27:1903-1916
The tight control of gene expression at the level of both transcription and post-transcriptional RNA processing is essential for mammalian development. We here investigate the role of protein arginine methyltransferase 5 (PRMT5), a putative splicing
Autor:
Karen Willekens, Frédéric Amant, Frederick A. Derheimer, Zahid Quyoom Bonday, Robert M. Campbell, Aljosja Rogiers, Soo Yong Tan, Hualong Yan, Cheryl M. Koh, Mark Fiers, Mark Shackleton, Manikandan Lakshmanan, Jean-Christophe Marine, Ratnacaram Chandrahas Koumar, Marco Bezzi, Christine Blattner, Shun Xie Teo, Ernesto Guccione, Enrico Radaelli, Soon Thye Lim, Michael Dewaele, Tommaso Tabaglio, Els Hermans, Florian Rambow, Muthafar Al-Haddawi, Vinay Tergaonkar, Diana Low
Publikováno v:
Journal of clinical investigation, 126(1), 68-84. The American Society for Clinical Investigation
MDM4 is a promising target for cancer therapy, as it is undetectable in most normal adult tissues but often upregulated in cancer cells to dampen p53 tumor-suppressor function. The mechanisms that underlie MDM4 upregulation in cancer cells are largel
Autor:
Cheryl M. Koh, Marco Bezzi, Diana H. P. Low, Wei Xia Ang, Shun Xie Teo, Florence P. H. Gay, Muthafar Al-Haddawi, Soo Yong Tan, Motomi Osato, Arianna Sabò, Bruno Amati, Keng Boon Wee, Ernesto Guccione
Publikováno v:
Nature. 523(7558)
Deregulated expression of the MYC transcription factor occurs in most human cancers and correlates with high proliferation, reprogrammed cellular metabolism and poor prognosis. Overexpressed MYC binds to virtually all active promoters within a cell,
Autor:
Scaglione, Antonella, Patzig, Julia, Jialiang Liang, Frawley, Rebecca, Bok, Jabez, Mela, Angeliki, Yattah, Camila, Jingxian Zhang, Shun Xie Teo, Ting Zhou, Shuibing Chen, Bernstein, Emily, Canoll, Peter, Guccione, Ernesto, Casaccia, Patrizia
Publikováno v:
Nature Communications; 7/19/2018, Vol. 9 Issue 1, p1-14, 14p, 8 Graphs
Autor:
Bezzi, Marco1,2, Shun Xie Teo1, Muller, Julius1, Wei Chuen Mok1, Sahu, Sanjeeb Kumar1, Vardy, Leah A.3,4, Bonday, Zahid Q.5, Guccione, Ernesto1,2 eguccione@imcb.a-star.edu.sg
Publikováno v:
Genes & Development. Sep2013, Vol. 27 Issue 17, p6-6. 1p.