Výsledky vyhledávání - "Shun Wa Tsang"

Akademický článek

Myeloid-intrinsic cell cycle-related kinase drives immunosuppression to promote tumorigenesis

Autor: Jingying Zhou, Huanyu Wang, Ting Shu, Jing Wang, Weiqin Yang, Jingqing Li, Lipeng Ding, Man Liu, Hanyong Sun, John Wong, Paul Bo-san Lai, Shun-Wa Tsang, Simon E. Ward, King-Lau Chow, Joseph Jao-yiu Sung, Alfred Sze-Lok Cheng

Publikováno v: iScience, Vol 26, Iss 10, Pp 107626- (2023)

Summary: Massive expansion of immature and suppressive myeloid cells is a common feature of malignant solid tumors. Over-expression of cyclin-dependent kinase 20, also known as cell cycle-related kinase (CCRK), in hepatocellular carcinoma (HCC) corre

Externí odkaz: https://doaj.org/article/64467f2d4d01480781df060e9f589903

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Akademický článek

An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)

Obesity increases the risk of hepatocellular carcinoma (HCC) especially in men. Here the authors find a potential mechanistic explanation by showing that, in mice, obesity-induced STAT3 cooperates with the androgen receptor to activate the mTORC path

Externí odkaz: https://doaj.org/article/6dd5d597aab145d5bf368e0227da0aaf

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Parallel bimodal single-cell sequencing of transcriptome and methylome provides molecular and translational insights on oocyte maturation and maternal aging

Autor: Fa-Li, Zhang, Yan, Qian, Wei-Dong, Li, Qin, Cao, Ho Ting, Chu, Alfred Chun Sui, Luk, Shun Wa, Tsang, Wai Kit, Lee, Patrick Ming-Kuen, Tang, Wai-Yee, Chan, King Lau, Chow, David Yiu Leung, Chan, Tin Chiu, Li, Kevin Yuk-Lap, Yip, Wei, Shen, Tin-Lap, Lee

Publikováno v: Genomics. 114(3)

Advanced maternal aging has become a worldwide public health issue contributing to female fertility decline. To provide a complete landscape of transcriptome and epigenetic changes during oocyte aging and maturation, we applied a parallel bimodal gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::604386541d19afc2af2a1d4eb1d6b20b
https://pubmed.ncbi.nlm.nih.gov/35526740

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Retraction notice to 'Parallel bimodal single-cell sequencing of transcriptome and methylome provides molecular and translational insights on oocyte maturation and maternal aging' [Genomics, 114/3 (2022) 110379]

Autor: Fa-Li Zhang, Wei-Dong Li, Ho Ting Chu, Alfred Chun Sui Luk, Shun Wa Tsang, Wai Kit Lee, Patrick Ming-Kuen Tang, Wai-Yee Chan, King Lau Chow, David Yiu Leung Chan, Tin Chiu Li, Wei Shen, Tin-Lap Lee

Publikováno v: Genomics. 114:110541

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9ec9d108f408c637330041020f2bfd8
https://doi.org/10.1016/j.ygeno.2022.110541

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Publikováno v: Cell Mol Immunol

The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types. Although a role for cancer cell invasion programs has been well characterized, whether and how liver-intrinsic factors drive metastatic spread is in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a45b7dab4fe6fcd91973eeb9540f3eb4
https://europepmc.org/articles/PMC8115036/

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An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications

Obesity increases the risk of hepatocellular carcinoma (HCC) especially in men, but the molecular mechanism remains obscure. Here, we show that an androgen receptor (AR)-driven oncogene, cell cycle-related kinase (CCRK), collaborates with obesity-ind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3aa7df10473f627f38a57b8f1c37e1b
https://doaj.org/article/6dd5d597aab145d5bf368e0227da0aaf

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Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy

Publikováno v: Gut. 67:931-944

ObjectiveMyeloid-derived suppressor cells (MDSCs) contribute to tumour immunosuppressive microenvironment and immune-checkpoint blockade resistance. Emerging evidence highlights the pivotal functions of cyclin-dependent kinases (CDKs) in tumour immun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b098e27e9e30ba71a3901a6b2fadc814
https://doi.org/10.1136/gutjnl-2017-314032

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Generation and characterization of pathogenic Mab21l2(R51C) mouse model

Autor: Yanjiang Guo, Long Hei Chan, Shun Wa Tsang, King Lau Chow, Yingyu Huang

Publikováno v: Genesis (New York, N.Y. : 2000). 56(11-12)

MAB21L2(R51C) is one of the five documented MAB21L2 mutations in human patients with bilateral eye malformations identified via whole exome sequencing. In addition to the eye abnormality, patients with MAB21L2 R51C/+ mutation also have skeletal dyspl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8809f7b94a75bcf72a9361be541d982
https://pubmed.ncbi.nlm.nih.gov/30375740

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The chondrocytic journey in endochondral bone growth and skeletal dysplasia

Autor: Shun Wa Tsang, Kwok Yeung Tsang, Kathryn S.E. Cheah, Danny Chan

Publikováno v: Birth Defects Research Part C: Embryo Today: Reviews. 102:52-73

The endochondral bones of the skeleton develop from a cartilage template and grow via a process involving a cascade of chondrocyte differentiation steps culminating in formation of a growth plate and the replacement of cartilage by bone. This process

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1139a7e099c5eab22aa1f7d2acce92ba
https://doi.org/10.1002/bdrc.21060

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