Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Shun Tanemoto"'
Downregulation of chemokine receptor 9 facilitates CD4+CD8αα+ intraepithelial lymphocyte development
Autor:
Keiko Ono, Tomohisa Sujino, Kentaro Miyamoto, Yosuke Harada, Satoshi Kojo, Yusuke Yoshimatsu, Shun Tanemoto, Yuzo Koda, Jiawen Zheng, Kazutoshi Sayama, Tsuyoshi Koide, Toshiaki Teratani, Yohei Mikami, Kaoru Takabayashi, Nobuhiro Nakamoto, Naoki Hosoe, Mariya London, Haruhiko Ogata, Daniel Mucida, Ichiro Taniuchi, Takanori Kanai
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Intestinal intraepithelial lymphocytes (IELs) reside in the gut epithelial layer, where they help in maintaining intestinal homeostasis. Peripheral CD4+ T cells can develop into CD4+CD8αα+ IELs upon arrival at the gut epithelium via the la
Externí odkaz:
https://doaj.org/article/f3798e0a3c1041ce9d72da327e0971b3
Autor:
Satoko Umeda, Tomohisa Sujino, Kentaro Miyamoto, Yusuke Yoshimatsu, Yosuke Harada, Keita Nishiyama, Yoshimasa Aoto, Keika Adachi, Naoki Hayashi, Kimiko Amafuji, Nobuko Moritoki, Shinsuke Shibata, Nobuo Sasaki, Masashi Mita, Shun Tanemoto, Keiko Ono, Yohei Mikami, Jumpei Sasabe, Kaoru Takabayashi, Naoki Hosoe, Toshihiko Suzuki, Toshiro Sato, Koji Atarashi, Toshiaki Teratani, Haruhiko Ogata, Nobuhiro Nakamoto, Daisuke Shiomi, Hiroshi Ashida, Takanori Kanai
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 6, Pp 1011-1031 (2023)
Background & Aims: D-amino acids, the chiral counterparts of protein L-amino acids, were primarily produced and utilized by microbes, including those in the human gut. However, little was known about how orally administered or microbe-derived D-amino
Externí odkaz:
https://doaj.org/article/3561896e2e8b4eb4a814259518b66ff8
Autor:
Shun Tanemoto, Tomohisa Sujino, Kentaro Miyamoto, Jonathan Moody, Yusuke Yoshimatsu, Yoshinari Ando, Ikuko Koya, Yosuke Harada, Anna Okuzawa Tojo, Keiko Ono, Yukie Hayashi, Kaoru Takabayashi, Koji Okabayashi, Toshiaki Teratani, Yohei Mikami, Nobuhiro Nakamoto, Naoki Hosoe, Haruhiko Ogata, Chung-Chau Hon, Jay W. Shin, Takanori Kanai
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Cytotoxic CD4+ T cells (CD4-CTLs) show the presence of cytolytic granules, which include the enzymes granzyme and perforin. The cells have a pathogenic and protective role in various diseases, including cancer, viral infection, and autoimmune disease
Externí odkaz:
https://doaj.org/article/64af4c68a566413d876fafee75f8128e
Autor:
Yosuke Harada, Tomohisa Sujino, Kentaro Miyamoto, Ena Nomura, Yusuke Yoshimatsu, Shun Tanemoto, Satoko Umeda, Keiko Ono, Yohei Mikami, Nobuhiro Nakamoto, Kaoru Takabayashi, Naoki Hosoe, Haruhiko Ogata, Tuneo Ikenoue, Atsushi Hirao, Yoshiaki Kubota, Takanori Kanai
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104021- (2022)
Summary: Intestinal intraepithelial lymphocytes (IELs), the first line of defense against microbial and dietary antigens, are classified as natural or induced based on their origin and receptor expression. Induced CD4+CD8αα+TCRβ+ T cells (double p
Externí odkaz:
https://doaj.org/article/0603827265af48c8be951c4f33903cb5
Autor:
Naoki Hosoe, Kaoru Takabayashi, Makoto Naganuma, Yusuke Yoshimatsu, Shun Tanemoto, Ena Nomura, Takanori Kanai, Tomohisa Sujino, Masayuki Shimoda, Makoto Mutaguchi, Haruhiko Ogata
Publikováno v:
Digestive Diseases and Sciences. 66:3141-3148
Ulcerative colitis (UC) is characterized by chronic intestinal epithelial damage, and previous studies have evaluated the epithelial structure of patients with active UC using electron microscopy. This study aimed to assess the intestinal epithelial
Autor:
Ena Nomura, Nagamu Inoue, Tomohisa Sujino, Yohei Mikami, Yuya Hagihara, Yasushi Iwao, Makoto Mutaguchi, Haruhiko Ogata, Tomohiro Fukuda, Shinya Sugimoto, Kayoko Fukuhara, Takanori Kanai, Kaoru Takabayashi, Shinta Mizuno, Makoto Naganuma, Takayuki Abe, Kosaku Nanki, Yusuke Yoshimatsu, Shun Tanemoto
Publikováno v:
Journal of Gastroenterology and Hepatology
Background and Aim 5‐Aminosalicylic acid (5‐ASA) is a fundamental treatment for mild‐to‐moderate ulcerative colitis (UC). 5‐ASA is taken up into the colonic mucosa and metabolized to N‐acetyl‐5‐ASA (Ac‐5‐ASA). Few studies have ass
Autor:
Yosuke, Harada, Tomohisa, Sujino, Kentaro, Miyamoto, Ena, Nomura, Yusuke, Yoshimatsu, Shun, Tanemoto, Satoko, Umeda, Keiko, Ono, Yohei, Mikami, Nobuhiro, Nakamoto, Kaoru, Takabayashi, Naoki, Hosoe, Haruhiko, Ogata, Tuneo, Ikenoue, Atsushi, Hirao, Yoshiaki, Kubota, Takanori, Kanai
Publikováno v:
iScience. 25(4)
Intestinal intraepithelial lymphocytes (IELs), the first line of defense against microbial and dietary antigens, are classified as natural or induced based on their origin and receptor expression. Induced CD4
Autor:
Kosuke Yoshida, Satoko Umeda, Keiko Ono, Yohei Mikami, Shinta Mizuno, Tomohiro Fukuda, Yasushi Iwao, Kayoko Fukuhara, Kaoru Takabayashi, Makoto Mutaguchi, Takanori Kanai, Makoto Naganuma, Shinya Sugimoto, Ena Nomura, Haruhiko Ogata, Yusuke Yoshimatsu, Shun Tanemoto, Kosaku Nanki, Tomohisa Sujino
Publikováno v:
Digestion. 101:492-498
Background: Indigo naturalis (IN) consists of ligands for the aryl hydrocarbon receptor and exhibits anti-inflammatory effects. Previously, we demonstrated that an 8-week treatment with oral IN is effective in inducing a clinical response in patients
Autor:
Yusuke Yoshimatsu, Tomohisa Sujino, Kentaro Miyamoto, Yosuke Harada, Shun Tanemoto, Keiko Ono, Satoko Umeda, Kosuke Yoshida, Toshiaki Teratani, Takahiro Suzuki, Yohei Mikami, Nobuhiro Nakamoto, Nobuo Sasaki, Kaoru Takabayashi, Naoki Hosoe, Haruhiko Ogata, Kazuaki Sawada, Takeshi Imamura, Akihiko Yoshimura, Takanori Kanai
Publikováno v:
Cell Reports. 39:110773
Autor:
Ena Nomura, Tomohisa Sujino, Yasushi Iwao, Yoshiaki Takada, Yusuke Yoshimatsu, Shun Tanemoto, Makoto Mutaguchi, Takanori Kanai, Tomohiro Fukuda, Yuya Hagihara, Haruhiko Ogata, Kosaku Nanki, Keiko Ono, Satoko Umeda, Kaoru Takabayashi, Kayoko Fukuhara, Makoto Naganuma, Shinya Sugimoto, Kosuke Yoshida, Yohei Mikami
Publikováno v:
American Journal of Gastroenterology. 114:S24-S25