Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Shun Sakuraba"'
Autor:
Junichi Higo, Kota Kasahara, Gert-Jan Bekker, Benson Ma, Shun Sakuraba, Shinji Iida, Narutoshi Kamiya, Ikuo Fukuda, Hidetoshi Kono, Yoshifumi Fukunishi, Haruki Nakamura
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract A GA-guided multidimensional virtual-system coupled molecular dynamics (GA-mD-VcMD) simulation was conducted to elucidate binding mechanisms of a middle-sized flexible molecule, bosentan, to a GPCR protein, human endothelin receptor type B (
Externí odkaz:
https://doaj.org/article/07b56a258af1478fb2760e436655ec63
Autor:
Ko Sato, Amarjeet Kumar, Keisuke Hamada, Chikako Okada, Asako Oguni, Ayumi Machiyama, Shun Sakuraba, Tomohiro Nishizawa, Osamu Nureki, Hidetoshi Kono, Kazuhiro Ogata, Toru Sengoku
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
An upregulation of NSD2, a histone H3 lysine 36 (H3K36) methyltransferase is linked to multiple myeloma and other types of cancer. Here, the authors provide insights into the regulatory mechanism of NSD2 by determining the 2.8 Å cryo-EM structure of
Externí odkaz:
https://doaj.org/article/a236ab6e4fda4b94ae5feb9f8adae7d1
Autor:
Sayaka Takehara, Shun Sakuraba, Bunzo Mikami, Hideki Yoshida, Hisako Yoshimura, Aya Itoh, Masaki Endo, Nobuhisa Watanabe, Takayuki Nagae, Makoto Matsuoka, Miyako Ueguchi-Tanaka
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Enzymatic inactivation of gibberellins and auxin, via GA2ox3 and DAO respectively, contributes to hormone homeostasis in plants. Here Takehara et al. show that both enzymes multimerize in a substrate-concentration-dependent manner, and that this mult
Externí odkaz:
https://doaj.org/article/56ff451a10f1487984c25d0a085a2812
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 1, p e1009804 (2022)
Nonstructural protein 1 (nsp1) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a 180-residue protein that blocks translation of host mRNAs in SARS-CoV-2-infected cells. Although it is known that SARS-CoV-2's own RNA evades nsp1's h
Externí odkaz:
https://doaj.org/article/722c8425d04442239c1f7f3c8d1318dd
Autor:
Brianna J. Klein, Suk Min Jang, Catherine Lachance, Wenyi Mi, Jie Lyu, Shun Sakuraba, Krzysztof Krajewski, Wesley W. Wang, Simone Sidoli, Jiuyang Liu, Yi Zhang, Xiaolu Wang, Becka M. Warfield, Andrew J. Kueh, Anne K. Voss, Tim Thomas, Benjamin A. Garcia, Wenshe R. Liu, Brian D. Strahl, Hidetoshi Kono, Wei Li, Xiaobing Shi, Jacques Côté, Tatiana G. Kutateladze
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Acetylation of histone H3K23 has emerged as an essential posttranslational modification, yet this epigenetic mark remains poorly understood. Here, the authors identify the native MORF complex as a histone H3K23-specific acetyltransferase and show tha
Externí odkaz:
https://doaj.org/article/78758c527c604e018605e9ed73ff1cd5
Publikováno v:
Biophysics and Physicobiology, Vol 16 (2019)
Eukaryotic genome is packaged in a nucleus in the form of chromatin. The fundamental structural unit of the chromatin is the protein-DNA complex, nucleosome, where DNA of about 150 bp is wrapped around a histone core almost twice. In cellular process
Externí odkaz:
https://doaj.org/article/50efefbd73f94398919097ec764e67de
Publikováno v:
BMC Bioinformatics, Vol 19, Iss S1, Pp 85-95 (2018)
Abstract Background It is known that functional RNAs often switch their functions by forming different secondary structures. Popular tools for RNA secondary structures prediction, however, predict the single ‘best’ structures, and do not produce
Externí odkaz:
https://doaj.org/article/931a84668fd64b70be84d3a263748634
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 10, p e1007439 (2019)
[This corrects the article DOI: 10.1371/journal.pcbi.1006024.].
Externí odkaz:
https://doaj.org/article/780a795d820d485aa4978c378b5ee718
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 3, p e1006024 (2018)
The eukaryotic genome is packaged into a nucleus in the form of chromatin. The fundamental structural unit of chromatin is a protein-DNA complex, the nucleosome, where 146 or 147 base pairs of DNA wrap 1.75 times around a histone core. To function in
Externí odkaz:
https://doaj.org/article/d6283832f9b5481c8df4053db11abaee
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 3, p e1004788 (2016)
Acetylation of lysine residues in histone tails is associated with gene transcription. Because histone tails are structurally flexible and intrinsically disordered, it is difficult to experimentally determine the tail conformations and the impact of
Externí odkaz:
https://doaj.org/article/c6a8a2a083e346d0b7e95d881cb045bd