Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Shun Kageyama"'
Autor:
Ge Peng, Saya Tsukamoto, Risa Ikutama, Hai Le Thanh Nguyen, Yoshie Umehara, Juan V. Trujillo-Paez, Hainan Yue, Miho Takahashi, Takasuke Ogawa, Ryoma Kishi, Mitsutoshi Tominaga, Kenji Takamori, Jiro Kitaura, Shun Kageyama, Masaaki Komatsu, Ko Okumura, Hideoki Ogawa, Shigaku Ikeda, François Niyonsaba
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 17 (2022)
Human β-defensin-3 (hBD-3) exhibits antimicrobial and immunomodulatory activities; however, its contribution to autophagy regulation remains unclear, and the role of autophagy in the regulation of the epidermal barrier in atopic dermatitis (AD) is p
Externí odkaz:
https://doaj.org/article/730aa69b1d874b99b25b902f4ecf9b79
Autor:
Shun Kageyama, Sigurdur Runar Gudmundsson, Yu-Shin Sou, Yoshinobu Ichimura, Naoki Tamura, Saiko Kazuno, Takashi Ueno, Yoshiki Miura, Daisuke Noshiro, Manabu Abe, Tsunehiro Mizushima, Nobuaki Miura, Shujiro Okuda, Hozumi Motohashi, Jin-A Lee, Kenji Sakimura, Tomoyuki Ohe, Nobuo N. Noda, Satoshi Waguri, Eeva-Liisa Eskelinen, Masaaki Komatsu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Liquid-liquid phase separation of p62/SQSTM1 has been previously described, although the significance in vivo remains unclear. Here the authors show p62 droplets contain ubiquitin, autophagy-related proteins and Keap1 to serve as platform of not only
Externí odkaz:
https://doaj.org/article/50de4fe4211844b99cf42f1bafec73c8
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 2 (2021)
Selective autophagy contributes to the degradation of condensates, such as sequestosome 1-bodies, also called p62/SQSTM1-bodies. We showed that endogenous p62 forms gel-like structures, which serve as platforms for autophagosome formation and nuclear
Externí odkaz:
https://doaj.org/article/68622f3883c04ed2a4147f43508bd5a1
Autor:
Toshiyuki Nagata, Kentaro Minami, Masatatsu Yamamoto, Tsubasa Hiraki, Masashi Idogawa, Katsumi Fujimoto, Shun Kageyama, Kazuhiro Tabata, Kohichi Kawahara, Kazuhiro Ueda, Ryuji Ikeda, Yukio Kato, Masaaki Komatsu, Akihide Tanimoto, Tatsuhiko Furukawa, Masami Sato
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11509 (2021)
Lung cancer constitutes a threat to human health. BHLHE41 plays important roles in circadian rhythm and cell differentiation as a negative regulatory transcription factor. This study investigates the role of BHLHE41 in lung cancer progression. We ana
Externí odkaz:
https://doaj.org/article/8a5678a30f1c4920bcc82d3506332165
Publikováno v:
International Journal of Cell Biology, Vol 2012 (2012)
Salmonella enterica serovar Typhimurium enter epithelial cells and take up residence there. Within epithelial cells, a portion of the bacteria are surrounded by an autophagosome-like double-membrane structure, and they are still residing within the S
Externí odkaz:
https://doaj.org/article/7738e1a3253f45eda1ff43477bbceaa5
Autor:
Reo Kurusu, Yuki Fujimoto, Hideaki Morishita, Daisuke Noshiro, Shuhei Takada, Koji Yamano, Hideaki Tanaka, Ritsuko Arai, Shun Kageyama, Tomoko Funakoshi, Satoko Komatsu-Hirota, Hikari Taka, Saiko Kazuno, Yoshiki Miura, Masato Koike, Toshifumi Wakai, Satoshi Waguri, Nobuo N. Noda, Masaaki Komatsu
Publikováno v:
Developmental Cell.
Publikováno v:
Journal of Rural Planning Studies. 2:69-76
Autor:
Ryo Ikeda, Daisuke Noshiro, Hideaki Morishita, Shuhei Takada, Shun Kageyama, Yuko Fujioka, Tomoko Funakoshi, Satoko Komatsu-Hirota, Ritsuko Arai, Elena Ryzhii, Manabu Abe, Tomoaki Koga, Mitsuyoshi Nakao, Kenji Sakimura, Arata Horii, Satoshi Waguri, Yoshinobu Ichimura, Nobuo N Noda, Masaaki Komatsu
NRF2 is a transcription factor responsible for antioxidant stress responses that is usually regulated in a redox-dependent manner. p62 bodies formed by liquid-liquid phase separation contain Ser349-phosphorylated p62, which participates in the redox-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e5ffad33fb79c265c7815d9022be972
https://doi.org/10.1101/2022.12.21.521356
https://doi.org/10.1101/2022.12.21.521356
Autor:
Ichio Shimada, Tatsuro Maruyama, Yoshinori Ohsumi, Tomoyuki Fukuda, Yuki Ishii, Nobuo N. Noda, Tomotake Kanki, Masaaki Komatsu, Shun Kageyama, Jahangir Md. Alam, Hitoshi Nakatogawa, Hiromi Kirisako
Publikováno v:
Nature Structural & Molecular Biology. 28:583-593
Autophagosome biogenesis is an essential feature of autophagy. Lipidation of Atg8 plays a critical role in this process. Previous in vitro studies identified membrane tethering and hemi-fusion/fusion activities of Atg8, yet definitive roles in autoph
Autor:
Risa Ikutama, Ge Peng, Saya Tsukamoto, Yoshie Umehara, Juan Valentin Trujillo-Paez, Hainan Yue, Hai Le Thanh Nguyen, Miho Takahashi, Shun Kageyama, Masaaki Komatsu, Ko Okumura, Hideoki Ogawa, Shigaku Ikeda, François Niyonsaba
Publikováno v:
Journal of Investigative Dermatology. 143:751-761.e7
Human cathelicidin LL-37 is a multifunctional antimicrobial peptide that exhibits antimicrobial and immunomodulatory activities. LL-37 regulates skin barrier function and was recently reported to activate autophagy in macrophages. Because autophagy d