Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Shun Hirasawa"'
Publikováno v:
Chemistry Letters. 51:985-988
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e00c37644ae8b87929e166e991f13c5
https://doi.org/10.1246/cl.220299
https://doi.org/10.1246/cl.220299
Publikováno v:
Organic & Biomolecular Chemistry. 19:6897-6903
We herein report a novel, short asymmetric synthesis of (−)-dehydro-exo-brevicomin (DHB, 1), a sex pheromone isolated from house mice, in 44% overall yield, the highest yield reported so far, over eight steps from trans-3-hexen-1-ol (7). We success
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c020759237694c7867fbe5919a64ac3
https://doi.org/10.1039/d1ob00952d
https://doi.org/10.1039/d1ob00952d
Autor:
Yoshinori Kohmura, Shun Hirasawa
Publikováno v:
Organic Process Research & Development. 24:2830-2839
The plasma kallikrein inhibitor ASP5069 is a promising drug candidate for the treatment of edema and hematoma and for the prevention of bleeding during surgery. Here, we report the development of a...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4450569f7adfae30aecaf3ca516d1c6
https://doi.org/10.1021/acs.oprd.0c00291
https://doi.org/10.1021/acs.oprd.0c00291
Publikováno v:
Organicbiomolecular chemistry. 19(31)
We herein report a novel, short asymmetric synthesis of (-)-dehydro-exo-brevicomin (DHB, 1), a sex pheromone isolated from house mice, in 44% overall yield, the highest yield reported so far, over eight steps from trans-3-hexen-1-ol (7). We successfu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d1a4a19148c73c1ca8ffc2a673ae7357
https://pubmed.ncbi.nlm.nih.gov/34328158
https://pubmed.ncbi.nlm.nih.gov/34328158
Autor:
Takumi Takahashi, Ryoki Orii, Shun Hirasawa, Minoru Okada, Koji Kobayashi, Kazuyoshi Obitsu, Shigeru Ieda, Yuji Takahama, Norihiro Ueda, Kazuhiro Takeguchi, Takahiro Akiba, Atsushi Ohigashi
Publikováno v:
Organic Process Research & Development. 23:512-523
Our effort toward the process improvement of anaplastic lymphoma kinase (ALK) inhibitor ASP3026 (1) is described. A cost-effective and practical synthesis of 1 was accomplished as a result of the change of starting material from 2,4-dichloro-1,3,5-tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c1bd70225621a79f0a623374a1eafc2
https://doi.org/10.1021/acs.oprd.8b00427
https://doi.org/10.1021/acs.oprd.8b00427
Autor:
Narihito Ogawa, Takahiro Hasegawa, Shinnosuke Wakamori, Nobuhiro Kanomata, Kazunori Souma, Shinnosuke Sakai, Ken Mukai, Mamoru Aizawa, Shun Hirasawa, Makoto Emoto
Publikováno v:
The Journal of Organic Chemistry. 83:14457-14464
Azaspirene and related congeners, which possess various biological activities, have a unique spirocyclic core structure. However, there are few studies on the chemical properties of (-)-azaspirene, despite the fact that it may provide important insig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69503bf40f064f670c025e8df073edad
https://doi.org/10.1021/acs.joc.8b02223
https://doi.org/10.1021/acs.joc.8b02223
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:2770-2772
Salvinorin A (SalA) is a potent and selective agonist of the kappa-opioid receptor (KOR), but its instability has frustrated medicinal chemistry efforts. Treatment of SalA with weak bases like DBU leads to C8 epimerization with loss of receptor affin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f63cc70efa24c72f4105ed91d5c11a
https://doi.org/10.1016/j.bmcl.2018.01.055
https://doi.org/10.1016/j.bmcl.2018.01.055
Autor:
Minoru Okada, Hiroshi Takiyama, Kazuhiro Takeguchi, Shun Hirasawa, Shigeru Ieda, Kazuyoshi Obitsu, Ryoki Orii
Publikováno v:
Organic Process Research & Development. 20:970-976
ASP3026 (N-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}-N′-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine) was developed as a novel and selective inhibitor of the fusion protein EML4-ALK. Five polymorphs of ASP3026 (A01
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b52ad1c3162912588d9887269da30404
https://doi.org/10.1021/acs.oprd.6b00068
https://doi.org/10.1021/acs.oprd.6b00068
Salvinorin A (SalA) is a potent and selective agonist of the kappa-opioid receptor (KOR), but its instability has frustrated medicinal chemistry efforts. Treatment of SalA with weak bases like DBU leads to C8 epimerization with loss of receptor affin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eb7aeedffaa6bd6fa6cc1ce5a157305
https://doi.org/10.26434/chemrxiv.5728286
https://doi.org/10.26434/chemrxiv.5728286
Publikováno v:
The Journal of Veterinary Medical Science
We designed a new method of measuring the length of the ulnar nerve and determining standard values for F-wave parameters of the ulnar nerve in clinically normal beagles. Nerve length must be precisely measured to determine F-wave latency and conduct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e01d9f37233a586dcfbaf62933c82072
http://europepmc.org/articles/PMC4300375
http://europepmc.org/articles/PMC4300375