Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Shun, TY"'
Autor:
Grandis, Jennifer, Gough, AH, Chen, N, Shun, TY, Lezon, TR, Boltz, RC, Reese, CE, Wagner, J, Vernetti, LA, Grandis, JR, Lee, AV
Publikováno v:
Grandis, Jennifer; Gough, AH; Chen, N; Shun, TY; Lezon, TR; Boltz, RC; et al.(2014). Identifying and quantifying heterogeneity in high content analysis: Application of heterogeneity indices to drug discovery. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/8zt9r6sz
One of the greatest challenges in biomedical research, drug discovery and diagnostics is understanding how seemingly identical cells can respond differently to perturbagens including drugs for disease treatment. Although heterogeneity has become an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::d5c01bf9056370c6519f980a2e9fe1d6
http://www.escholarship.org/uc/item/8zt9r6sz
http://www.escholarship.org/uc/item/8zt9r6sz
Autor:
Lefever DE; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA., Miedel MT; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA., Pei F; Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA., DiStefano JK; Diabetes and Fibrotic Disease Unit, Translational Genomics Research Institute TGen, Phoenix, AZ 85004, USA., Debiasio R; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA., Shun TY; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA., Saydmohammed M; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA., Chikina M; Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA 15261, USA., Vernetti LA; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA., Soto-Gutierrez A; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15203, USA., Monga SP; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA., Bataller R; Division of Gastroenterology Hepatology and Nutrition, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA., Behari J; Division of Gastroenterology Hepatology and Nutrition, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.; UPMC Liver Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA., Yechoor VK; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Division of Endocrinology and Metabolism, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15203, USA., Bahar I; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA., Gough A; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA., Stern AM; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA., Taylor DL; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Publikováno v:
Metabolites [Metabolites] 2022 Jun 07; Vol. 12 (6). Date of Electronic Publication: 2022 Jun 07.
Autor:
Saydmohammed M; University of Pittsburgh Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA., Jha A; University of Pittsburgh Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA., Mahajan V; University of Pittsburgh Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA., Gavlock D; University of Pittsburgh Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA., Shun TY; University of Pittsburgh Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA., DeBiasio R; University of Pittsburgh Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA., Lefever D; University of Pittsburgh Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA., Li X; University of Pittsburgh Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA., Reese C; University of Pittsburgh Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA., Kershaw EE; Department of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, PA 15261, USA., Yechoor V; Department of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, PA 15261, USA., Behari J; Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Pittsburgh, PA 15261, USA.; UPMC Liver Clinic, University of Pittsburgh, Pittsburgh, PA 15261, USA., Soto-Gutierrez A; Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA 15261, USA., Vernetti L; University of Pittsburgh Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA., Stern A; University of Pittsburgh Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA., Gough A; University of Pittsburgh Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA., Miedel MT; University of Pittsburgh Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA., Lansing Taylor D; University of Pittsburgh Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Publikováno v:
Experimental biology and medicine (Maywood, N.J.) [Exp Biol Med (Maywood)] 2021 Nov; Vol. 246 (22), pp. 2420-2441. Date of Electronic Publication: 2021 May 06.
Autor:
Nmezi B; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Vollmer LL; Drug Discovery Institute, University of Pittsburgh Medical School, Pittsburgh, PA, USA., Shun TY; Drug Discovery Institute, University of Pittsburgh Medical School, Pittsburgh, PA, USA., Gough A; Drug Discovery Institute, University of Pittsburgh Medical School, Pittsburgh, PA, USA.; Department of Computational and Systems Biology, University of Pittsburgh Medical School, Pittsburgh, PA, USA., Rolyan H; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Internal Medicine, Yale University, New Haven, CT., Liu F; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Jia Y; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Padiath QS; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Vogt A; Drug Discovery Institute, University of Pittsburgh Medical School, Pittsburgh, PA, USA.; Department of Computational and Systems Biology, University of Pittsburgh Medical School, Pittsburgh, PA, USA.
Publikováno v:
SLAS discovery : advancing life sciences R & D [SLAS Discov] 2020 Sep; Vol. 25 (8), pp. 939-949. Date of Electronic Publication: 2020 Apr 30.
Autor:
Schurdak M; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. mes234@pitt.edu and Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Vernetti L; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. mes234@pitt.edu and Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Bergenthal L; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. mes234@pitt.edu., Wolter QK; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. mes234@pitt.edu., Shun TY; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. mes234@pitt.edu., Karcher S; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. mes234@pitt.edu., Taylor DL; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. mes234@pitt.edu and Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Gough A; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. mes234@pitt.edu and Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Publikováno v:
Lab on a chip [Lab Chip] 2020 Apr 14; Vol. 20 (8), pp. 1472-1492.
Autor:
Ngo M; 1 Drug Discovery Institute, University of Pittsburgh Medical School, Pittsburgh, PA, USA., Wechter N; 2 Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA., Tsai E; 3 Apollo Medical Optics, Ltd., Taipei City, Taiwan (R.O.C.)., Shun TY; 1 Drug Discovery Institute, University of Pittsburgh Medical School, Pittsburgh, PA, USA., Gough A; 1 Drug Discovery Institute, University of Pittsburgh Medical School, Pittsburgh, PA, USA.; 4 Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA., Schurdak ME; 1 Drug Discovery Institute, University of Pittsburgh Medical School, Pittsburgh, PA, USA.; 4 Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.; 5 Cancer Therapeutics Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Schwacha A; 2 Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA., Vogt A; 1 Drug Discovery Institute, University of Pittsburgh Medical School, Pittsburgh, PA, USA.; 4 Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.; 5 Cancer Therapeutics Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Publikováno v:
SLAS discovery : advancing life sciences R & D [SLAS Discov] 2019 Jul; Vol. 24 (6), pp. 669-681. Date of Electronic Publication: 2019 Feb 25.
Autor:
Johnston PA; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Room 586 Salk Hall, 3501 Terrace Street, Pittsburgh, PA, 15261, USA. paj18@pitt.edu., Sen M; Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Hua Y; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Room 586 Salk Hall, 3501 Terrace Street, Pittsburgh, PA, 15261, USA., Camarco DP; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Room 586 Salk Hall, 3501 Terrace Street, Pittsburgh, PA, 15261, USA., Shun TY; University of Pittsburgh Drug Discovery Institute, Pittsburgh, PA, 15260, USA., Lazo JS; Department of Pharmacology, University of Virginia, P.O. Box 800735, Charlottesville, VA, 22908, USA.; Department of Chemistry, University of Virginia, P.O. Box 800735, Charlottesville, VA, 22908, USA., Grandis JR; University of Pittsburgh Cancer Institute, Pittsburgh, PA, 15232, USA.; Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, 15261, USA.; Department of Otolaryngology - Head and Neck Surgery, University of California, San Francisco, Box 0558550, 16th Street, San Francisco, CA, 94143, USA.
Publikováno v:
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2018; Vol. 1683, pp. 229-244.
Autor:
Jia S, Miedel MT, Ngo M, Hessenius R, Chen N, Wang P, Bahreini A, Li Z, Ding Z, Shun TY, Zuckerman DM, Taylor DL, Puhalla SL, Lee AV, Oesterreich S, Stern AM
Publikováno v:
Oncology [Oncology] 2018; Vol. 94 (3), pp. 176-189. Date of Electronic Publication: 2018 Jan 06.
Autor:
Gough A; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA, USA. gough@pitt.edu.; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA. gough@pitt.edu., Shun TY; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA, USA., Taylor DL; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.; Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA., Schurdak M; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.; Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA.
Publikováno v:
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2018; Vol. 1745, pp. 25-46.
Autor:
Gough A; 1 Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.; 2 University of Pittsburgh Drug Discovery Institute, Pittsburgh, PA, USA., Stern AM; 1 Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.; 2 University of Pittsburgh Drug Discovery Institute, Pittsburgh, PA, USA., Maier J; 3 Department of Family Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Lezon T; 1 Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.; 2 University of Pittsburgh Drug Discovery Institute, Pittsburgh, PA, USA., Shun TY; 2 University of Pittsburgh Drug Discovery Institute, Pittsburgh, PA, USA., Chennubhotla C; 1 Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.; 2 University of Pittsburgh Drug Discovery Institute, Pittsburgh, PA, USA., Schurdak ME; 1 Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.; 2 University of Pittsburgh Drug Discovery Institute, Pittsburgh, PA, USA.; 4 University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA., Haney SA; 5 Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Taylor DL; 1 Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.; 2 University of Pittsburgh Drug Discovery Institute, Pittsburgh, PA, USA.; 4 University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.
Publikováno v:
SLAS discovery : advancing life sciences R & D [SLAS Discov] 2017 Mar; Vol. 22 (3), pp. 213-237. Date of Electronic Publication: 2017 Jan 06.