Zobrazeno 1 - 10
of 206
pro vyhledávání: '"Shun, Kaneko"'
Autor:
Shun Kaneko, Shunsuke Imai, Tomomi Uchikubo-Kamo, Tamao Hisano, Nobuaki Asao, Mikako Shirouzu, Ichio Shimada
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract G-protein-coupled receptors (GPCRs) play pivotal roles in various physiological processes. These receptors are activated to different extents by diverse orthosteric ligands and allosteric modulators. However, the mechanisms underlying these
Externí odkaz:
https://doaj.org/article/8986cdcaf6aa480fa00140791f388d6f
Autor:
Jun Tsuchiya, Masato Miyoshi, Sei Kakinuma, Fukiko Kawai-Kitahata, Akihide Kamiya, Taro Shimizu, Ayako Sato, Keiya Watakabe, Tomohiro Mochida, Kento Inada, Rion Kamimae, Shun Kaneko, Miyako Murakawa, Sayuri Nitta, Mina Nakagawa, Mamoru Watanabe, Yasuhiro Asahina, Ryuichi Okamoto
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 19, Iss 2, Pp 101422- (2025)
Background & Aims: Hepatitis B virus (HBV)-DNA integration into the host genome contributes to hepatocellular carcinoma (HCC) development. KMT2B is the second most frequent locus of HBV-DNA integration in HCC; however, its role and function remain un
Externí odkaz:
https://doaj.org/article/a471b682b3ab4b5b919e70619ee207fe
Autor:
Shun Kaneko, Yasuhiro Asahina, Miyako Murakawa, Seishin Azuma, Kento Inada, Tomohiro Mochida, Keiya Watakabe, Taro Shimizu, Jun Tsuchiya, Masato Miyoshi, Fukiko Kawai-Kitahata, Sayuri Nitta, Marie Takahashi, Tomoyuki Fujioka, Mitsuhiro Kishino, Tatsuhiko Anzai, Sei Kakinuma, Mina Nakagawa, Ryuichi Okamoto
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0297882 (2024)
Background/aimAntiviral hepatitis and systemic therapies for hepatocellular carcinoma (HCC) remarkably progressed in the recent 10 years. This study aimed to reveal the actual transition and changes in the prognosis and background liver disease in no
Externí odkaz:
https://doaj.org/article/86941efca4b84e08aa7173fe99b4bef6
Autor:
Shokichi Takahama, Sachiyo Yoshio, Yuji Masuta, Hirotomo Murakami, Ryotaro Sakamori, Shun Kaneko, Takashi Honda, Miyako Murakawa, Masaya Sugiyama, Masayuki Kurosaki, Yasuhiro Asahina, Tetsuo Takehara, Victor Appay, Tatsuya Kanto, Takuya Yamamoto
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Despite treatment, hepatitis B surface antigen (HBsAg) persists in patients with chronic hepatitis B (CHB), suggesting the likely presence of the virus in the body. CD8+ T cell responses are essential for managing viral replication, but their effect
Externí odkaz:
https://doaj.org/article/1d09105d328b4551aba7580d6b0d95b3
Autor:
Koji Yamashita, Masayuki Kurosaki, Hiroyuki Nakanishi, Yuki Tanaka, Shun Ishido, Kento Inada, Sakura Kirino, Yuka Hayakawa, Hiroaki Matsumoto, Tsubasa Nobusawa, Tatsuya Kakegawa, Mayu Higuchi, Kenta Takaura, Shohei Tanaka, Chiaki Maeyashiki, Shun Kaneko, Nobuharu Tamaki, Yutaka Yasui, Kaoru Tsuchiya, Yuka Takahashi, Ryoichi Miyazaki, Takashi Ashikaga, Nobuyuki Enomoto, Namiki Izumi
Publikováno v:
JGH Open, Vol 6, Iss 11, Pp 774-781 (2022)
Abstract Aims Portopulmonary hypertension (PoPH) is a subtype of pulmonary arterial hypertension related to portal hypertension. The definitive diagnosis of PoPH is made by invasive right heart catheterization. Alternatively, pulmonary arterial hyper
Externí odkaz:
https://doaj.org/article/4a52742d455c41f19ef4407435667969
Autor:
Shun Kaneko, Kaoru Tsuchiya, Yutaka Yasui, Yuki Tanaka, Kento Inada, Shun Ishido, Sakura Kirino, Koji Yamashita, Yuka Hayakawa, Tsubasa Nobusawa, Hiroaki Matsumoto, Tatsuya Kakegawa, Mayu Higuchi, Kenta Takaura, Shohei Tanaka, Chiaki Maeyashiki, Nobuharu Tamaki, Yuka Takahashi, Hiroyuki Nakanishi, Takumi Irie, Shun‐Ichi Ariizumi, Masayuki Kurosaki, Namiki Izumi
Publikováno v:
JGH Open, Vol 6, Iss 5, Pp 301-308 (2022)
Abstract Background and Aim Conversion surgery (CS), which aims to cure after systematic therapy, is only scarcely reported in the field of hepatocellular carcinoma (HCC). However, advancements in systemic therapy for HCC are expected to increase the
Externí odkaz:
https://doaj.org/article/896f5a83aa354941b6e45e2c416ab912
Autor:
Shuhei Sekiguchi, Kaoru Tsuchiya, Yutaka Yasui, Kento Inada, Sakura Kirino, Koji Yamashita, Yuka Hayakawa, Leona Osawa, Mayu Higuchi, Kenta Takaura, Chiaki Maeyashiki, Shun Kaneko, Nobuharu Tamaki, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Yasuhiro Asahina, Ryuichi Okamoto, Masayuki Kurosaki, Namiki Izumi
Publikováno v:
Cancer Reports, Vol 5, Iss 11, Pp n/a-n/a (2022)
Abstract Background Therapeutic strategies for unresectable hepatocellular carcinoma (u‐HCC) in geriatric patients are important for real‐world practice. However, there remain no established biomarkers or therapeutic strategies regarding the best
Externí odkaz:
https://doaj.org/article/983096be3b1246c68b4d1ba13cd275bb
Autor:
Kento Inada, Shun Kaneko, Masayuki Kurosaki, Koji Yamashita, Sakura Kirino, Leona Osawa, Yuka Hayakawa, Shuhei Sekiguchi, Mayu Higuchi, Kenta Takaura, Chiaki Maeyashiki, Nobuharu Tamaki, Yutaka Yasui, Jun Itakura, Yuka Takahashi, Kaoru Tsuchiya, Hiroyuki Nakanishi, Ryuichi Okamoto, Namiki Izumi
Publikováno v:
JGH Open, Vol 5, Iss 9, Pp 1085-1091 (2021)
Abstract Background and Aim Administration of tenofovir alafenamide (TAF) as prevention or treatment of hepatitis B virus (HBV) reactivation is not well known. The aim of this study is to reveal the efficacy and safety of TAF against HBV reactivation
Externí odkaz:
https://doaj.org/article/29aba27863ce4648b818183455c89aa4
Autor:
Nobuharu Tamaki, Masayuki Kurosaki, Sakura Kirino, Koji Yamashita, Leona Osawa, Shuhei Sekiguchi, Yuka Hayakawa, Wan Wang, Mao Okada, Mayu Higuchi, Kenta Takaura, Chiaki Maeyashiki, Shun Kaneko, Yutaka Yasui, Kaoru Tsuchiya, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Nobuyuki Enomoto, Namiki Izumi
Publikováno v:
JGH Open, Vol 4, Iss 3, Pp 429-432 (2020)
Background and Aim Loss of hepatitis B surface antigen (HBsAg) is an important goal in the treatment of chronic hepatitis B. We investigated whether switching from long‐term entecavir (ETV) administration to tenofovir (TFV) (tenofovir alafenamide [
Externí odkaz:
https://doaj.org/article/07f5cac2e4b041099bd76c677205797c
Autor:
Ayako Sato, Sei Kakinuma, Masato Miyoshi, Akihide Kamiya, Tomoyuki Tsunoda, Shun Kaneko, Jun Tsuchiya, Taro Shimizu, Eiko Takeichi, Sayuri Nitta, Fukiko Kawai‐Kitahata, Miyako Murakawa, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Naohiko Koshikawa, Motoharu Seiki, Hiromitsu Nakauchi, Yasuhiro Asahina, Mamoru Watanabe
Publikováno v:
Hepatology Communications, Vol 4, Iss 2, Pp 235-254 (2020)
Formation of intrahepatic bile ducts (IHBDs) proceeds in accordance with their microenvironment. Particularly, mesenchymal cells around portal veins regulate the differentiation and ductular morphogenesis of cholangiocytes in the developing liver; ho
Externí odkaz:
https://doaj.org/article/3a3b1a9365ce4ae795001341232c9d24