The inflammatory and oxidative phenotype of gestational diabetes is epigenetically transmitted to the offspring: role of methyltransferase MLL1-induced H3K4me3.

Autor: Di Pietrantonio N; Cardiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm 171 76, Sweden.; Department of Medical, Oral and Biotechnological Sciences, Center for Advanced Studies and Technology-CAST, University G. D'Annunzio of Chieti-Pescara, Chieti 66100, Italy., Sánchez-Ceinos J; Cardiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm 171 76, Sweden., Shumliakivska M; Cardiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm 171 76, Sweden., Rakow A; Department of Neonatology, Karolinska University Hospital, Stockholm, Sweden., Mandatori D; Department of Medical, Oral and Biotechnological Sciences, Center for Advanced Studies and Technology-CAST, University G. D'Annunzio of Chieti-Pescara, Chieti 66100, Italy., Di Tomo P; Department of Medical, Oral and Biotechnological Sciences, Center for Advanced Studies and Technology-CAST, University G. D'Annunzio of Chieti-Pescara, Chieti 66100, Italy., Formoso G; Department of Medicine and Aging Sciences, Center for Advanced Studies and Technology-CAST, University G. D'Annunzio of Chieti-Pescara, Chieti, Italy., Bonfini T; Department of Oncology Hematology, Pescara Hospital, Pescara, Italy., Baldassarre MPA; Department of Medicine and Aging Sciences, Center for Advanced Studies and Technology-CAST, University G. D'Annunzio of Chieti-Pescara, Chieti, Italy., Sennström M; Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden., Almahmeed W; Heart and Vascular Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE., Pandolfi A; Department of Medical, Oral and Biotechnological Sciences, Center for Advanced Studies and Technology-CAST, University G. D'Annunzio of Chieti-Pescara, Chieti 66100, Italy., Cosentino F; Cardiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm 171 76, Sweden.; Heart and Vascular Theme, Karolinska University Hospital, Stockholm 171 76, Sweden.

Publikováno v: European heart journal [Eur Heart J] 2024 Dec 23; Vol. 45 (48), pp. 5171-5185.

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Cell-intrinsic effects of clonal hematopoiesis in heart failure.

Autor: Abplanalp WT; Institute of Cardiovascular Regeneration, Goethe University, Frankfurt, Germany.; German Center for Cardiovascular Research DZHK, Partner Site Frankfurt Rhine-Main, Berlin, Germany.; Cardiopulmonary Institute, Goethe University, Frankfurt, Germany., Schuhmacher B; Institute of Cardiovascular Regeneration, Goethe University, Frankfurt, Germany.; Cardiopulmonary Institute, Goethe University, Frankfurt, Germany., Cremer S; Institute of Cardiovascular Regeneration, Goethe University, Frankfurt, Germany.; German Center for Cardiovascular Research DZHK, Partner Site Frankfurt Rhine-Main, Berlin, Germany.; Cardiopulmonary Institute, Goethe University, Frankfurt, Germany., Merten M; Institute of Cardiovascular Regeneration, Goethe University, Frankfurt, Germany.; German Center for Cardiovascular Research DZHK, Partner Site Frankfurt Rhine-Main, Berlin, Germany.; Cardiopulmonary Institute, Goethe University, Frankfurt, Germany., Shumliakivska M; Institute of Cardiovascular Regeneration, Goethe University, Frankfurt, Germany.; German Center for Cardiovascular Research DZHK, Partner Site Frankfurt Rhine-Main, Berlin, Germany.; Cardiopulmonary Institute, Goethe University, Frankfurt, Germany., Macinkovic I; Institute of Cardiovascular Regeneration, Goethe University, Frankfurt, Germany., Zeiher AM; Institute of Cardiovascular Regeneration, Goethe University, Frankfurt, Germany.; German Center for Cardiovascular Research DZHK, Partner Site Frankfurt Rhine-Main, Berlin, Germany.; Cardiopulmonary Institute, Goethe University, Frankfurt, Germany., John D; Institute of Cardiovascular Regeneration, Goethe University, Frankfurt, Germany.; German Center for Cardiovascular Research DZHK, Partner Site Frankfurt Rhine-Main, Berlin, Germany.; Cardiopulmonary Institute, Goethe University, Frankfurt, Germany., Dimmeler S; Institute of Cardiovascular Regeneration, Goethe University, Frankfurt, Germany. dimmeler@em.uni-frankfurt.de.; German Center for Cardiovascular Research DZHK, Partner Site Frankfurt Rhine-Main, Berlin, Germany. dimmeler@em.uni-frankfurt.de.; Cardiopulmonary Institute, Goethe University, Frankfurt, Germany. dimmeler@em.uni-frankfurt.de.

Publikováno v: Nature cardiovascular research [Nat Cardiovasc Res] 2023 Sep; Vol. 2 (9), pp. 819-834. Date of Electronic Publication: 2023 Sep 04.

Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform.

Autor: Bojkova D; Institute of Medical Virology, University Hospital, Goethe-University, Paul Ehrlich-Straße 40, 60596 Frankfurt am Main, Germany., Reus P; Institute of Medical Virology, University Hospital, Goethe-University, Paul Ehrlich-Straße 40, 60596 Frankfurt am Main, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany., Panosch L; Institute of Medical Virology, University Hospital, Goethe-University, Paul Ehrlich-Straße 40, 60596 Frankfurt am Main, Germany., Bechtel M; Institute of Medical Virology, University Hospital, Goethe-University, Paul Ehrlich-Straße 40, 60596 Frankfurt am Main, Germany., Rothenburger T; Institute of Medical Virology, University Hospital, Goethe-University, Paul Ehrlich-Straße 40, 60596 Frankfurt am Main, Germany., Kandler JD; Institute of Medical Virology, University Hospital, Goethe-University, Paul Ehrlich-Straße 40, 60596 Frankfurt am Main, Germany., Pfeiffer A; Institute of Medical Virology, University Hospital, Goethe-University, Paul Ehrlich-Straße 40, 60596 Frankfurt am Main, Germany., Wagner JUG; Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.; German Center for Cardiovascular Research (DZHK), partner site Rhine-Main, Goethe University, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.; Cardiopulmonary Institute (CPI), Goethe University, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany., Shumliakivska M; Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany., Dimmeler S; Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.; German Center for Cardiovascular Research (DZHK), partner site Rhine-Main, Goethe University, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.; Cardiopulmonary Institute (CPI), Goethe University, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany., Olmer R; Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery (HTTG), REBIRTH-Research Center for Translational Regenerative Medicine, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany., Martin U; Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery (HTTG), REBIRTH-Research Center for Translational Regenerative Medicine, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany., Vondran FWR; Department for General, Visceral and Transplant Surgery, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.; German Center for Infection Research, DZIF, Braunschweig, Inhoffenstraße 7, 38124 Braunschweig, Germany., Toptan T; Institute of Medical Virology, University Hospital, Goethe-University, Paul Ehrlich-Straße 40, 60596 Frankfurt am Main, Germany., Rothweiler F; Institute of Medical Virology, University Hospital, Goethe-University, Paul Ehrlich-Straße 40, 60596 Frankfurt am Main, Germany.; Dr Petra Joh Research Institute, Komturstraße 3A, 60596 Frankfurt am Main, Germany., Zehner R; Institute for Forensic Medicine, University Hospital, Goethe-University, Kennedyallee 104, 60596 Frankfurt am Main, Germany., Rabenau HF; Institute of Medical Virology, University Hospital, Goethe-University, Paul Ehrlich-Straße 40, 60596 Frankfurt am Main, Germany., Osman KL; UK Health Safety Agency, National Infection Service, Porton Down, Salisbury, Wiltshire SP4 0JG, UK., Pullan ST; UK Health Safety Agency, National Infection Service, Porton Down, Salisbury, Wiltshire SP4 0JG, UK., Carroll MW; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, Oxford University, Roosevelt Drive, Headington, Oxford OX3 7BN, UK.; NIHR Health Protection Unit in Emerging and Zoonotic Infections, Department of Clinical Infection, Microbiology and Immunology, University of Liverpool, Liverpool L69 7BE, UK., Stack R; School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK., Ciesek S; Institute of Medical Virology, University Hospital, Goethe-University, Paul Ehrlich-Straße 40, 60596 Frankfurt am Main, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.; German Center for Infection Research, DZIF, Braunschweig, Inhoffenstraße 7, 38124 Braunschweig, Germany., Wass MN; School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK., Michaelis M; School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK., Cinatl J Jr; Institute of Medical Virology, University Hospital, Goethe-University, Paul Ehrlich-Straße 40, 60596 Frankfurt am Main, Germany.; Dr Petra Joh Research Institute, Komturstraße 3A, 60596 Frankfurt am Main, Germany.

Publikováno v: IScience [iScience] 2023 Feb 17; Vol. 26 (2), pp. 105944. Date of Electronic Publication: 2023 Jan 07.