Identification, characterization, and structure of a tRNA splicing enzyme RNA 5'-OH kinase from the pathogenic fungi Mucorales.

Autor: Ghosh S; Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA., Wimberly-Gard G; Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA., Jacewicz A; Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA., Schwer B; Microbiology and Immunology Department, Weill Cornell Medical College, New York, New York 10065, USA., Shuman S; Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA shumans@mskcc.org.

Publikováno v: RNA (New York, N.Y.) [RNA] 2024 Nov 18; Vol. 30 (12), pp. 1674-1685. Date of Electronic Publication: 2024 Nov 18.

Chemical synthesis of 2″OMeNAD+ and its deployment as an RNA 2'-phosphotransferase (Tpt1) 'poison' that traps the enzyme on its abortive RNA-2'-PO4-(ADP-2″OMe-ribose) reaction intermediate.

Autor: Arnold J; Department of Chemistry, University of Konstanz, 78457 Konstanz, Germany., Ghosh S; Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Kasprzyk R; Department of Chemistry, University of Konstanz, 78457 Konstanz, Germany., Brakonier M; Department of Chemistry, University of Konstanz, 78457 Konstanz, Germany., Hanna M; Department of Chemistry, University of Konstanz, 78457 Konstanz, Germany., Marx A; Department of Chemistry, University of Konstanz, 78457 Konstanz, Germany., Shuman S; Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2024 Sep 23; Vol. 52 (17), pp. 10533-10542.

Structure and in vivo psoralen DNA crosslink repair activity of mycobacterial Nei2.

Autor: Warren GM; Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Shuman S; Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Publikováno v: MBio [mBio] 2024 Aug 14; Vol. 15 (8), pp. e0124824. Date of Electronic Publication: 2024 Jul 16.

Implementing a pragmatic clinical trial to tailor opioids for chronic pain on behalf of the IGNITE ADOPT PGx investigators.

Autor: Skaar TC; Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana, USA., Myers RA; Department of Medicine, Clinical Research Unit, Duke University School of Medicine, Duke University, Durham, North Carolina, USA., Fillingim RB; Department of Community Dentistry and Behavioral Science, University of Florida College of Dentistry, Gainesville, Florida, USA., Callaghan JT; Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana, USA., Cicali E; Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, College of Pharmacy, University of Florida, Gainesville, Florida, USA., Eadon MT; Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Division of Nephrology, Indiana University School of Medicine, Indianapolis, Indiana, USA., Elwood EN; Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, College of Pharmacy, University of Florida, Gainesville, Florida, USA., Ginsburg GS; All of Us Research Program, National Institutes of Health, Bethesda, Maryland, USA., Lynch S; Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana, USA., Nguyen KA; Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, College of Pharmacy, University of Florida, Gainesville, Florida, USA., Obeng AO; Pharmacy Department, Mount Sinai Health System, New York, New York, USA.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Department of Medicine, Division of General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Park H; Department of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville, Florida, USA.; Center for Drug Evaluation and Safety, University of Florida, Gainesville, Florida, USA., Pratt VM; Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA., Rosenman M; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Ann & Robert H. Lurie Children's Hospital of Chicago and Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Sadeghpour A; Duke Precision Medicine Program, Department of Medicine, Duke University, Durham, North Carolina, USA., Shuman S; The Institute for Family Health, New York, New York, USA., Singh R; Department of Medicine, Meharry Medical College, Nashville, Tennessee, USA., Tillman EM; Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana, USA., Volpi S; Division of Genomic Medicine, National Human Genome Research Institute, Bethesda, Maryland, USA., Wiisanen K; Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, College of Pharmacy, University of Florida, Gainesville, Florida, USA., Winterstein AG; Department of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville, Florida, USA.; Center for Drug Evaluation and Safety, University of Florida, Gainesville, Florida, USA., Horowitz CR; Institute for Health Equity Research, Icahn School of Medicine at Mount Sinai, New York City, New York, USA., Voora D; Duke Precision Medicine Program, Department of Medicine, Duke University, Durham, North Carolina, USA., Orlando L; Duke Precision Medicine Program, Department of Medicine, Duke University, Durham, North Carolina, USA., Chakraborty H; Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, USA., Van Driest S; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Peterson JF; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Cavallari LA; Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, College of Pharmacy, University of Florida, Gainesville, Florida, USA., Johnson JA; Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, College of Pharmacy, University of Florida, Gainesville, Florida, USA., Dexter PR; Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Regenstrief Institute, Inc., Indianapolis, Indiana, USA.

Publikováno v: Clinical and translational science [Clin Transl Sci] 2024 Aug; Vol. 17 (8), pp. e70005.

Deletions initiated by the vaccinia virus TopIB protein in yeast.

Autor: Cho JE; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA., Shaltz S; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA., Yakovleva L; Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Shuman S; Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Jinks-Robertson S; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: sue.robertson@duke.edu.

Publikováno v: DNA repair [DNA Repair (Amst)] 2024 May; Vol. 137, pp. 103664. Date of Electronic Publication: 2024 Mar 06.