Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Shumaila Afrin"'
Autor:
Binh An Nguyen, Virender Singh, Shumaila Afrin, Preeti Singh, Maja Pekala, Yasmin Ahmed, Rose Pedretti, Jacob Canepa, Andrew Lemoff, Barbara Kluve-Beckerman, Pawel M. Wydorski, Farzeen Chhapra, Lorena Saelices
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract ATTR amyloidosis results from the conversion of transthyretin into amyloid fibrils that deposit in tissues causing organ failure and death. This conversion is facilitated by mutations in ATTRv amyloidosis, or aging in ATTRwt amyloidosis. ATT
Externí odkaz:
https://doaj.org/article/8fc633682aa74991a520534aaeef48a7
Autor:
Binh An Nguyen, Virender Singh, Shumaila Afrin, Anna Yakubovska, Lanie Wang, Yasmin Ahmed, Rose Pedretti, Maria del Carmen Fernandez-Ramirez, Preeti Singh, Maja Pękała, Luis O. Cabrera Hernandez, Siddharth Kumar, Andrew Lemoff, Roman Gonzalez-Prieto, Michael R. Sawaya, David S. Eisenberg, Merrill Douglas Benson, Lorena Saelices
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract ATTR amyloidosis is caused by the deposition of transthyretin in the form of amyloid fibrils in virtually every organ of the body, including the heart. This systemic deposition leads to a phenotypic variability that has not been molecularly
Externí odkaz:
https://doaj.org/article/60a20b40007f4acdaf11442427648360
Autor:
Aaron T. Balana, Anne-Laure Mahul-Mellier, Binh A Nguyen, Mian Horvath, Afraah Javed, Eldon R. Hard, Yllza Jasiqi, Preeti Singh, Shumaila Afrin, Rose Pedretti, Virender Singh, Virginia M.-Y. Lee, Kelvin C. Luk, Lorena Saelices, Hilal A. Lashuel, Matthew R. Pratt
Publikováno v:
bioRxiv
The process of amyloid fibril formation remains one of the primary targets for developing diagnostics and treatments for several neurodegenerative diseases (NDDs). Amyloid-forming proteins such α-Synuclein and Tau, which are implicated in the pathog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9a9ba932fcb45cc42feb6f11579b5d
https://doi.org/10.1101/2023.03.07.531573
https://doi.org/10.1101/2023.03.07.531573
Autor:
Shumaila Afrin, Mohammad Tabish, Mohd Owais Ansari, G G Hammad Ahmad Shadab, Tarique Sarwar, Ahmad Perwez, Shahbaz Ahmed, Meher Rizvi, Yusra Rahman
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 41:538-549
H2 receptor antagonists are the medication given for treating stomach ulcers, but lately, reports have shown their role in healing several malignant ulcers. The present work entails the interaction of H2 blocker nizatidine with calf thymus (ct)-DNA f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e379aeda53e9c9295e147607372cd953
https://doi.org/10.1080/07391102.2021.2008496
https://doi.org/10.1080/07391102.2021.2008496
Autor:
Binh An Nguyen, Shumaila Afrin, Virender Singh, Yasmin Ahmed, Rose Pedretti, Maria del Carmen Fernandez-Ramirez, Merrill Douglas Benson, Michael Sawaya, Preeti Singh, Qin Cao, David Boyer, Alexander Pope, Pawel Wydorski, Siddharth Kumar, Farzeen Chhapra, David Eisenberg, Lorena Saelices
The deposition of amyloidogenic transthyretin (ATTR) in ATTR amyloidosis leads to an unexplained variety of clinical phenotypes, including cardiomyopathy. In brain amyloid conditions, there is an apparent association between the clinical phenotype an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81647da97a671b17e6c27971afdccf4c
https://doi.org/10.1101/2022.06.21.496949
https://doi.org/10.1101/2022.06.21.496949
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 38:3046-3058
The binding characteristic of anti-platelet drug dipyridamole has been investigated with a transport protein, serum albumin. A multi-spectroscopic approach has been employed, and the results were well supported by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::091dd6d6fd3c15ac8e805fc313120b9c
https://doi.org/10.1080/07391102.2019.1651220
https://doi.org/10.1080/07391102.2019.1651220
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 38:1375-1387
Nizatidine is a histamine H2 receptor antagonist which act by inhibiting the production of stomach acid, thereby, finds its application in treating various diseases related to the gastrointestinal tract. Studying albumin-drug interaction is important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c09afa934266b3186cb06d1d2492b7f9
https://doi.org/10.1080/07391102.2019.1604265
https://doi.org/10.1080/07391102.2019.1604265
Autor:
Shumaila Afrin, Mohd Owais Ansari, G G Hammad Ahmad Shadab, Shahbaz Ahmed, Mohammad Tabish, Tarique Sarwar, Yusra Rahman, Meher Rizvi
Publikováno v:
Journal of Molecular Structure. 1249:131626
The molecular mechanism behind the anti-cancer potential of dipyridamole, an antiplatelet drug was investigated by examining the interaction of dipyridamole with DNA as well as the genotoxicity and cytotoxicity associated with dipyridamole . Interact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d228c8b5294ec5efb4501ff7bebd2cf
https://doi.org/10.1016/j.molstruc.2021.131626
https://doi.org/10.1016/j.molstruc.2021.131626
Autor:
Abad Ali, Shumaila Afrin, Mohammed Amir Husain, Shamsuzzaman, Tarique Sarwar, Mohammad Tabish, Yusra Rahman
Publikováno v:
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 186:66-75
Ticlopidine is an anti-platelet drug which belongs to the thienopyridine structural family and exerts its effect by functioning as an ADP receptor inhibitor. Ticlopidine inhibits the expression of TarO gene in S. aureus and may provide protection aga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f322ce3a3228cfd79cd105eb6a9993c
https://doi.org/10.1016/j.saa.2017.05.073
https://doi.org/10.1016/j.saa.2017.05.073
Autor:
Tarique Sarwar, Abad Ali, Shumaila Afrin, Mohammad Tabish, Mohammed Amir Husain, Yusra Rahman, Shamsuzzaman
Publikováno v:
Archives of Biochemistry and Biophysics. :1-12
Pirenzepine is an anti-ulcer agent which belongs to the anti-cholinergic group of gastrointestinal disorder drugs and functions as an M1 receptor selective antagonist. Drug-DNA interaction studies are of great significance as it helps in the developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::016070ab5279529e435158f47625c98b
https://doi.org/10.1016/j.abb.2017.05.014
https://doi.org/10.1016/j.abb.2017.05.014