Zobrazeno 1 - 10
of 189
pro vyhledávání: '"Shuling Guo"'
Autor:
Sivagurunathan Sutharsan, Rainald Fischer, Wolfgang Gleiber, Alex Horsley, Jeff Crosby, Shuling Guo, Shuting Xia, Rosie Yu, Kenneth B. Newman, J. Stuart Elborn
Publikováno v:
ERJ Open Research, Vol 10, Iss 4 (2024)
Background Hyperactivity of epithelial sodium channel (ENaC) with increased sodium absorption is a feature of cystic fibrosis (CF). ION-827359 is a 2.5-generation antisense oligonucleotide targeted to reduce ENaC protein. This study evaluated ION-827
Externí odkaz:
https://doaj.org/article/85b98b185ea54aedaea0d4fbe75abcce
Publikováno v:
IUCrData, Vol 9, Iss 4, p x240360 (2024)
The molecule of the title NCNHCS pincer N-heterocyclic carbene palladium(II) complex, [PdBr(C21H25N3S)]Br, exhibits a slightly distorted square-planar coordination at the palladium(II) atom, with the five-membered chelate ring nearly planar. The six-
Externí odkaz:
https://doaj.org/article/254410e487ee4b97b3e6d048086fb7fc
Autor:
Zhaosong Meng, Jiacheng Liu, Zhipeng Feng, Shuling Guo, Mingzhe Wang, Zheng Wang, Zhe Li, Hongjie Li, Lei Sui
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-16 (2022)
Abstract Background Dental follicle stem cells (DFSCs) show mesenchymal stem cell properties with the potential for alveolar bone regeneration. Stem cell properties can be impaired by reactive oxygen species (ROS), prompting us to examine the importa
Externí odkaz:
https://doaj.org/article/d07dfad740924a729df257de439974d1
Autor:
Edward J. Sanderlin, Melissa M. Keenan, Martin Mense, Alexey S. Revenko, Brett P. Monia, Shuling Guo, Lulu Huang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Currently, there is no therapy for patients with cystic fibrosis caused by nonsense mutations. Here the authors show that CFTR mRNAs with nonsense codons are predominantly degraded by the SMG6-mediated branch of the NMD pathway, providing potential t
Externí odkaz:
https://doaj.org/article/0bd6da00b0e3497583db276b1d3e35c5
Autor:
Yuanyuan Qiao, Jesse W Wotring, Charles J Zhang, Xia Jiang, Lanbo Xiao, Andy Watt, Danielle Gattis, Eli Scandalis, Susan Freier, Yang Zheng, Carla D Pretto, Stephanie J Ellison, Eric E Swayze, Shuling Guo, Jonathan Z Sexton, Arul M Chinnaiyan
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0281281 (2023)
Although the COVID-19 pandemic began over three years ago, the virus responsible for the disease, SARS-CoV-2, continues to infect people across the globe. As such, there remains a critical need for development of novel therapeutics against SARS-CoV-2
Externí odkaz:
https://doaj.org/article/b1383e6888f74bf2952f326be5d9d180
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7455 (2023)
Heat shock proteins (HSPs) are a class of molecular chaperones with expression increased in response to heat or other stresses. HSPs regulate cell homeostasis by modulating the folding and maturation of intracellular proteins. Tooth development is a
Externí odkaz:
https://doaj.org/article/1b92d02423044aef85c7e102af929c97
Autor:
Nicholas J. Viney, Shuling Guo, Li‐Jung Tai, Brenda F. Baker, Mariam Aghajan, Shiangtung W. Jung, Rosie Z. Yu, Sheri Booten, Heather Murray, Todd Machemer, Sebastien Burel, Sue Murray, Gustavo Buchele, Sotirios Tsimikas, Eugene Schneider, Richard S. Geary, Merrill D. Benson, Brett P. Monia
Publikováno v:
ESC Heart Failure, Vol 8, Iss 1, Pp 652-661 (2021)
Abstract Aims Amyloidogenic transthyretin (ATTR) amyloidosis is a fatal disease characterized by progressive cardiomyopathy and/or polyneuropathy. AKCEA‐TTR‐LRx (ION‐682884) is a ligand‐conjugated antisense drug designed for receptor‐mediat
Externí odkaz:
https://doaj.org/article/3297462a8e6e4c1081fbb6040b37c72e
Autor:
Elena Grossi, Ivan Raimondi, Enrique Goñi, Jovanna González, Francesco P. Marchese, Vicente Chapaprieta, José I. Martín-Subero, Shuling Guo, Maite Huarte
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
SWI/SNF complexes regulate chromatin architecture and gene expression. Here the authors report the RNA interactome of SMARCB1-containing SWI/SNF complexes, showing the function of SMARCB1-interacting long noncoding RNA SWINGN in transcriptional activ
Externí odkaz:
https://doaj.org/article/312881ea5ccf4917ac2bc11fe60be750
Publikováno v:
Journal of Immunology Research, Vol 2022 (2022)
Objective. To analyze the role of PD-1/PD-L1 signaling pathway in regulating T cell activation and secretion of proinflammatory factors in atrial fibrillation. Methods. Forty-five patients with atrial fibrillation admitted to the cardiology departmen
Externí odkaz:
https://doaj.org/article/5940cfed28144f9885a32a7b4861c656
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13414 (2022)
Mediator complex subunit 1 (MED1) is a coactivator of multiple transcription factors and plays a key role in regulating epidermal homeostasis as well as skin wound healing. It is unknown, however, whether it plays a role in healing oral mucosal wound
Externí odkaz:
https://doaj.org/article/67be9f3097aa42ccbeaf0ce05875367c