Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Shulin Ju"'
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 6, Pp 1843-1852 (2020)
FUS is a nucleic acid binding protein that, when mutated, cause a subset of familial amyotrophic lateral sclerosis (ALS). Expression of FUS in yeast recapitulates several pathological features of the disease-causing mutant proteins, including nuclear
Externí odkaz:
https://doaj.org/article/cb9f4e81996a406997ba1f39144ca93a
Autor:
Shulin Ju, Daniel F Tardiff, Haesun Han, Kanneganti Divya, Quan Zhong, Lynne E Maquat, Daryl A Bosco, Lawrence J Hayward, Robert H Brown, Susan Lindquist, Dagmar Ringe, Gregory A Petsko
Publikováno v:
PLoS Biology, Vol 9, Iss 4, p e1001052 (2011)
FUS/TLS is a nucleic acid binding protein that, when mutated, can cause a subset of familial amyotrophic lateral sclerosis (fALS). Although FUS/TLS is normally located predominantly in the nucleus, the pathogenic mutant forms of FUS/TLS traffic to, a
Externí odkaz:
https://doaj.org/article/8b86bc019d774b7c96ffcc6d00dbf142
Mutations in Fused in Sarcoma (FUS), an RNA binding protein that functions in multiple steps in gene expression regulation and RNA processing, are known to cause familial amyotrophic lateral sclerosis (ALS). Since this discovery, mutations in several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ceccf15bf16d2ca278db4c22697b750
https://doi.org/10.21203/rs.3.rs-437201/v1
https://doi.org/10.21203/rs.3.rs-437201/v1
Presentation of poster 1906A at TAGC 2020 Online. File includes a PDF of the poster (TAGC2020Online_AnnabelVAlmazan_Poster1906A.pdf).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d3f65d289c9616eab4cd9661ba0344
Publikováno v:
J Vis Exp
Budding yeast has been widely used as a model in studying proteins associated with human diseases. Genome-wide genetic screening is a powerful tool commonly used in yeast studies. The expression of a number of neurodegenerative disease-associated pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ed4070e61401d0061925340413c580e
https://doi.org/10.3791/57978-v
https://doi.org/10.3791/57978-v
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by rapidly progressive degeneration of motor neurons in the brain and spinal cord. Although most forms of ALS are sporadic (sALS), ∼10% of cases are inherited in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9cd981b3469491fee3e47c6c17a6396
https://europepmc.org/articles/PMC5441790/
https://europepmc.org/articles/PMC5441790/
Autor:
Shulin Ju, Lynne E. Maquat, Robert D. Dayton, Kasey L. Jackson, R L Klein, Gregory A. Petsko, Elysse A. Orchard, Dagmar Ringe
Publikováno v:
Gene Therapy. 22:20-28
Nonsense-mediated mRNA decay (NMD) is an RNA surveillance mechanism that requires upframeshift protein 1 (UPF1). This study demonstrates that human UPF1 exerts protective effects in a rat paralysis model based on the amyotrophic lateral sclerosis (AL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c4588c3cdc240e153ec073ccfa6df65
https://doi.org/10.1038/gt.2014.101
https://doi.org/10.1038/gt.2014.101
Autor:
Fariba Chegini, Oriana S. Fisher, Tim Chataway, Debajyoti Datta, Anuradha Landeru, Craig J. Thomas, Chun Xiang Wu, Dagmar Ringe, Christopher Burlak, James A. Wells, Fang Wu, Shulin Ju, Mark R. Cookson, Gregory A. Petsko, Quyen Q. Hoang, Matthew B. Boxer, Wei Ping Gai, David Miller, Wei Wang, Linh T.T. Nguyen, Feng Guo
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 113, iss 34
The aggregation of α-synuclein (aSyn) leading to the formation of Lewy bodies is the defining pathological hallmark of Parkinson's disease (PD). Rare familial PD-associated mutations in aSyn render it aggregation-prone; however, PD patients carrying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79062bc51494cd3230827194979192e4
https://escholarship.org/uc/item/4v28n1jb
https://escholarship.org/uc/item/4v28n1jb
Autor:
Giuseppe Verdile, Michelle E. Ehrlich, Veer Bala Gupta, Dagmar Ringe, Gregory A. Petsko, Shulin Ju, Renae Barr, Sonia E. Sankovich, Ian Macreadie, Prashant Bharadwaj, Sam Gandy, Joanne M. Caine, M. Lenard Lachenmayer, John W. Steele, Zhenyu Yue, Ralph N. Martins
Publikováno v:
Journal of Alzheimer's Disease. 32:949-967
Latrepirdine (Dimebon), an anti-histamine, has shown some benefits in trials of neurodegenerative diseases characterized by accumulation of aggregated or misfolded protein such as Alzheimer's disease (AD) and has been shown to promote the removal of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79ff35de96d6ee8f4388c79cc7dbbbf
https://doi.org/10.3233/jad-2012-120178
https://doi.org/10.3233/jad-2012-120178
Autor:
Iván E. Alfaro, Prashant Bharadwaj, Shulin Ju, Soong Ho Kim, Gregory A. Petsko, A. Friss, Dagmar Ringe, John W. Steele, Zhenyu Yue, Renae Barr, Luz Delgado, Veer Bala Gupta, Aryeh Stock, J. Liken, Michelle E. Ehrlich, Rong Wang, Andrew Asher Protter, Sebastian Bernales, Ralph N. Martins, Sam Gandy, M.L. Lachenmayer, Giuseppe Verdile, Georgia Dolios
Publikováno v:
Molecular psychiatry
Latrepirdine (Dimebon; dimebolin) is a neuroactive compound that was associated with enhanced cognition, neuroprotection and neurogenesis in laboratory animals, and has entered phase II clinical trials for both Alzheimer's disease and Huntington's di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a635836dd43e6a66c4e3e550934c2684
https://doi.org/10.1038/mp.2012.115
https://doi.org/10.1038/mp.2012.115