Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Shulei Zhu"'
Autor:
Yifan Zhang, Mengyuan Ding, Lei Wang, Sicheng Yin, Liang Zhang, Xuemei Cao, Zhiyang Chen, Weinan Li, Qingsong Guo, Shulei Zhu, Wei Lu, Tong Yang
Publikováno v:
PLoS ONE, Vol 18, Iss 12 (2023)
Externí odkaz:
https://doaj.org/article/401fd2773ac047228d80b5cc63a7825d
Autor:
Lei Sun, Jinfang Zhang, Jing-e Zhou, Jing Wang, Zhehao Wang, Shenggen Luo, Yeying Wang, Shulei Zhu, Fan Yang, Jie Tang, Wei Lu, Yiting Wang, Lei Yu, Zhiqiang Yan
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 18, Iss 1, Pp 100769- (2023)
The siRNA-loaded lipid nanoparticles have attracted much attention due to its significant gene silencing effect and successful marketization. However, the in vivo distribution and release of siRNA still cannot be effectively monitored. In this study,
Externí odkaz:
https://doaj.org/article/0b23e63d2eda42a7b5f14c0e2d1162f5
Publikováno v:
ACS Omega, Vol 7, Iss 1, Pp 1082-1089 (2021)
Externí odkaz:
https://doaj.org/article/945035367f7e49599169b58d37c5e8cd
Publikováno v:
Molecules, Vol 26, Iss 22, p 6986 (2021)
A series of novel fluorescent 4H-1-benzopyrans was designed and developed as near-infrared fluorescent molecules with a compact donor–acceptor-donor architecture. Spectral intensity of the fluorescent molecules M-1, M-2, M-3 varied significantly wi
Externí odkaz:
https://doaj.org/article/04fe77a638c74e89a92fb52f3423ff36
Autor:
Yingxin Lu, Danwen Sun, Donghuai Xiao, Yingying Shao, Mingbo Su, Yubo Zhou, Jia Li, Shulei Zhu, Wei Lu
Publikováno v:
Molecules, Vol 26, Iss 23, p 7241 (2021)
Histone deacetylases (HDACs) play important roles in cell growth, cell differentiation, cell apoptosis, and many other cellular processes. The inhibition of different classes of HDACs has been shown to be closely related to the therapy of cancers and
Externí odkaz:
https://doaj.org/article/d5e449ebe29b473cabf25b6033573f4f
Throughout the reported applications of EGFR inhibitors, it is usually employed with HDAC or other targets to design multi-target inhibitors for cancer treatment. In this paper, we designed a drug conjugate that targeted EGFR&HER2 and had inhibitory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::386bc3447fc9864e6110a598854def2f
https://doi.org/10.21203/rs.3.rs-2754084/v1
https://doi.org/10.21203/rs.3.rs-2754084/v1
Publikováno v:
MultiMedia Modeling ISBN: 9783031270765
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9e4ffbb58fd49ba3e1a90b5343aa15b
https://doi.org/10.1007/978-3-031-27077-2_1
https://doi.org/10.1007/978-3-031-27077-2_1
Publikováno v:
Bioorganic Chemistry. 137:106582
Autor:
Mengyuan Ding, Yingying Shao, Danwen Sun, Suorina Meng, Yi Zang, Yubo Zhou, Jia Li, Wei Lu, Shulei Zhu
Publikováno v:
Bioorganicmedicinal chemistry. 78
Epigenetic proteins are one of the important targets in the current research fields of cancer therapy. A family of bromodomain-containing (BRD) and extra terminal domain (BET) proteins act as epigenetic readers to regulate the expression of key oncog
Autor:
Shulei Zhu, Jieyu Liu, Donghuai Xiao, Peipei Wang, Jingkun Ma, Xiaobei Hu, Jingfeng Fu, Yubo Zhou, Jia Li, Wei Lu
Publikováno v:
European Journal of Medicinal Chemistry. 243:114786
Proteolysis targeting chimera (PROTAC) technology has received widespread attention in recent years as a promising strategy for drug development. Herein, we report a series of novel Wee1 degraders, which were designed and synthesized based on PROTAC