Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Shulamit Sebban"'
Autor:
Tayma Handal, Sarah Juster, Manar Abu Diab, Shira Yanovsky-Dagan, Fouad Zahdeh, Uria Aviel, Roni Sarel-Gallily, Shir Michael, Ester Bnaya, Shulamit Sebban, Yosef Buganim, Yotam Drier, Vincent Mouly, Stefan Kubicek, Walther J. A. A. van den Broek, Derick G. Wansink, Silvina Epsztejn-Litman, Rachel Eiges
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Epigenetic defects caused by hereditary or de novo mutations are implicated in various human diseases. It remains uncertain whether correcting the underlying mutation can reverse these defects in patient cells. Here we show by the analysis o
Externí odkaz:
https://doaj.org/article/f2f26f7be8be43019350e3bc09541979
Autor:
Moriyah Naama, Moran Rahamim, Valery Zayat, Shulamit Sebban, Ahmed Radwan, Dana Orzech, Rachel Lasry, Annael Ifrah, Mohammad Jaber, Ofra Sabag, Hazar Yassen, Areej Khatib, Silvina Epsztejn-Litman, Michal Novoselsky-Persky, Kirill Makedonski, Noy Deri, Debra Goldman-Wohl, Howard Cedar, Simcha Yagel, Rachel Eiges, Yosef Buganim
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Human trophoblast stem cells (hTSCs) can be derived from embryonic stem cells (hESCs) or be induced from somatic cells by OCT4, SOX2, KLF4 and MYC (OSKM). Here we explore whether the hTSC state can be induced independently of pluripotency, a
Externí odkaz:
https://doaj.org/article/d0c4b6ee563d4a668d24fbf8c84f012e
Autor:
Mohammad Jaber, Ahmed Radwan, Netanel Loyfer, Mufeed Abdeen, Shulamit Sebban, Areej Khatib, Hazar Yassen, Thorsten Kolb, Marc Zapatka, Kirill Makedonski, Aurelie Ernst, Tommy Kaplan, Yosef Buganim
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Ectopic transcription factor expression can reprogram mouse fibroblasts to pluripotent or trophoblast stem cells. Here the authors apply multi-omics analyses to the induction of pluripotency and trophoblast stem cell state from fibroblasts, comparing
Externí odkaz:
https://doaj.org/article/2c683347bd5b41c78db539dff13cbc7f
Autor:
Batel Shalom, Marganit Farago, Yaser Salaymeh, Shulamit Sebban, Eli Pikarsky, Shulamit Katzav
Publikováno v:
Cells, Vol 11, Iss 6, p 949 (2022)
Vav1 is normally and exclusively expressed in the hematopoietic system where it functions as a specific GDP/GTP nucleotide exchange factor (GEF), firmly regulated by tyrosine phosphorylation. Mutations and overexpression of Vav1 in hematopoietic mali
Externí odkaz:
https://doaj.org/article/f4c586d01f8a48b7a59718fcdd92b353
Autor:
Shulamit Sebban, Marganit Farago, Dan Gashai, Lena Ilan, Eli Pikarsky, Ittai Ben-Porath, Shulamit Katzav
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54321 (2013)
Vav1 functions as a signal transducer protein in the hematopoietic system, where it is exclusively expressed. Vav1 was recently implicated in several human cancers, including lung, pancreatic and neuroblasoma. In this study, we analyzed the expressio
Externí odkaz:
https://doaj.org/article/6ee1bc5e4a934a32b69c3d0f3d840105
Autor:
Shulamit Sebban, Debra Goldman-Wohl, Moriyah Naama, Hazar Yassen, Kirill Makedonski, Ofra Sabag, Noy Deri, Michal Novoselsky-Persky, Howard Cedar, Mohammad Jaber, Simcha Yagel, Ahmed Radwan, Rachel Eiges, Rachel Lasry, Moran Rahamim, Valery Zayat, Yosef Buganim, Dana Orzech, Silvina Epsztejn-Litman, Areej Khatib
SUMMARYRecent studies demonstrated that human trophoblast stem-like cells (hTS-like cells) can be derived from naïve embryonic stem cells or be induced from somatic cells by the pluripotency factors, OSKM. This raises two main questions; (i) whether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7896abe4a56d473be9ab26f5c4ea885
https://doi.org/10.1101/2021.11.10.468044
https://doi.org/10.1101/2021.11.10.468044
Autor:
Batel, Shalom, Marganit, Farago, Yaser, Salaymeh, Shulamit, Sebban, Matan, Risling, Eli, Pikarsky, Shulamit, Katzav
Publikováno v:
Cellular Signalling. 97:110395
The potential impact of Vav1 on human cancer was only recently acknowledged, as it is detected as a mutant or an overexpressed gene in various cancers, including lung cancer. Vav1, which is normally and exclusively expressed in the hematopoietic syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::807fe10278a2996d72ab63e5eb183359
https://doi.org/10.1016/j.cellsig.2022.110395
https://doi.org/10.1016/j.cellsig.2022.110395
Autor:
Mohammad Jaber, Ahmed Radwan, Netanel Loyfer, Mufeed Abdeen, Shulamit Sebban, Areej Khatib, Hazar Yassen, Thorsten Kolb, Marc Zapatka, Kirill Makedonski, Aurelie Ernst, Tommy Kaplan, Yosef Buganim
Publikováno v:
Nature communications. 13(1)
Following fertilization, it is only at the 32-64-cell stage when a clear segregation between cells of the inner cell mass and trophectoderm is observed, suggesting a ‘T’-shaped model of specification. Here, we examine whether the acquisition of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::616411f684f59d0b88637ae7363f8e3b
https://pubmed.ncbi.nlm.nih.gov/35715410
https://pubmed.ncbi.nlm.nih.gov/35715410
Autor:
Mohammad Jaber, Shulamit Sebban, Marc Zapatka, Kirill Makedonski, Ahmed Radwan, Yosef Buganim, Tommy Kaplan, Aurélie Ernst, Netanel Loyfer, Mufeed Abdeen, Thorsten Kolb
Publikováno v:
BioRxiv
Following fertilization, totipotent cells divide to generate two compartments in the early embryo: the inner cell mass (ICM) and trophectoderm (TE). It is only at the 32-64 -cell stage when a clear segregation between the two cell-types is observed,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1d8681a9519ed3907eac2bed4b2bfe3
https://doi.org/10.1101/2020.09.27.315259
https://doi.org/10.1101/2020.09.27.315259
Autor:
Marc Zapatka, Manasi Ratnaparkhe, Yosef Buganim, Shulamit Sebban, Peter Lichter, Milena Simovic, Peter Schmezer, Anna Jauch, Thorsten Kolb, Daniel Haag, Agata Rode, Aurélie Ernst, Umar Khalid, Frauke Devens, Michaela Hergt, John Wong
In vitro assays for clustered DNA lesions will facilitate the analysis of the mechanisms underlying complex genome rearrangements such as chromothripsis, including the recruitment of repair factors to sites of DNA double-strand breaks. We present a n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a364a8104697ba22bed362e72946f29b
https://doi.org/10.1101/2020.04.27.064105
https://doi.org/10.1101/2020.04.27.064105