Výsledky vyhledávání - "Shulamit Ron-Bigger"

Synergism between DNA methylation and macroH2A1 occupancy in epigenetic silencing of the tumor suppressor gene p16(CDKN2A)

Autor: Sara Isaac, Amir Eden, Nathalie Friedman, Michal Barzily-Rokni, Dan Michlin, Shulamit Ron-Bigger

Publikováno v: Nucleic Acids Research

Promoter hypermethylation and heterochromatinization is a frequent event leading to gene inactivation and tumorigenesis. At the molecular level, inactivation of tumor suppressor genes in cancer has many similarities to the inactive X chromosome in fe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f5594965d57ddd9daa034ad83b84e35
https://doi.org/10.1093/nar/gkq994

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Aberrant epigenetic silencing of tumor suppressor genes is reversed by direct reprogramming

Autor: Sara Isaac, Michael Bocker, Amir Eden, Frank Lyko, Ori Bar-Nur, Shulamit Ron-Bigger

Publikováno v: Stem cells (Dayton, Ohio). 28(8)

Direct reprogramming procedures reset the epigenetic memory of cells and convert differentiated somatic cells into pluripotent stem cells. In addition to epigenetic memory of cell identity, which is established during development, somatic cells can a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d735e7a035a1d43a84c28ab25204be06
https://pubmed.ncbi.nlm.nih.gov/20572015

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