Výsledky vyhledávání - "Shuko, Tachibana"

Pharmacokinetics and Disposition of DY-9760e, a Novel Calmodulin Antagonist, in Rats and Monkeys

Autor: Makoto Tanaka, Masaya Tachibana, Osamu Okazaki, Tadashi Kurata, Yuko Fujimaki, Kenichi Sudo, Shuko Tachibana

Publikováno v: Arzneimittelforschung. 55:135-144

DY-9760e (3-[2-[4-(3-chloro-2-methyl-phenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate, CAS 162496-41-5) is a novel calmodulin antagonist that is being evaluated for the treatment of ischemia. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a67e002af4c190b6290942e143be11
https://doi.org/10.1055/s-0031-1296835

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IN VITRO METABOLISM OF THE CALMODULIN ANTAGONIST DY-9760e (3-[2-[4-(3-CHLORO-2-METHYLPHENYL)-1-PIPERAZINYL]ETHYL]-5,6-DIMETHOXY-1-(4-IMIDAZOLYLMETHYL)-1H-INDAZOLE DIHYDROCHLORIDE 3.5 HYDRATE) BY HUMAN LIVER MICROSOMES: INVOLVEMENT OF CYTOCHROMES P450 IN ATYPICAL KINETICS AND POTENTIAL DRUG INTERACTIONS

Autor: Shuko Tachibana, Kenichi Sudo, Osamu Okazaki, Hiroyuki Yokoyama, Yuko Fujimaki

Publikováno v: Drug Metabolism and Disposition. 33:1628-1636

Human cytochrome P450 (P450) isozyme(s) responsible for metabolism of the calmodulin antagonist 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e) and kinetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad86c5eec7137ee73b5a87a6fe4a3150
https://doi.org/10.1124/dmd.105.004903

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Involvement of Vitamin D receptor in the intestinal induction of human ABCB1

Autor: Yasushi Yamazoe, Kiyoshi Nagata, Kouichi Yoshinari, Shuko Tachibana, Takayoshi Toriyabe, Tsubasa Chikada

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 37(8)

ABCB1 (P-glycoprotein) is an efflux transporter that limits the cellular uptake levels of various drugs in intestine, brain, and other tissues. The expression of human ABCB1 has recently been reported to be under the control of nuclear receptor NR1I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017fa7ffe403997851e18d79abd02787
https://pubmed.ncbi.nlm.nih.gov/19460946

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In vitro metabolism of the calmodulin antagonist DY-9760e (3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate) by human liver microsomes: involvement of cytochromes p450 in atypical kinetics and potential drug interactions

Autor: Shuko, Tachibana, Yuko, Fujimaki, Hiroyuki, Yokoyama, Osamu, Okazaki, Ken-ichi, Sudo

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 33(11)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6fdeb554129e756215331e28229703e7
https://pubmed.ncbi.nlm.nih.gov/16049129

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Simultaneous determination of testosterone metabolites in liver microsomes using column-switching semi-microcolumn high-performance liquid chromatography

Autor: Shuko Tachibana, Makoto Tanaka

Publikováno v: Analytical biochemistry. 295(2)

A sensitive and selective column-switching semi-microcolumn high-performance liquid chromatographic (HPLC) method has been developed for the simultaneous determination of testosterone and eight of its metabolites (6alpha-, 6beta-, 16alpha-, 16beta-,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b446d270268975ce4c62943d09c7de69
https://pubmed.ncbi.nlm.nih.gov/11488629

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Determination of a novel calmodulin antagonist, 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1- (4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate, DY-9760e, in human plasma using solid-phase extraction and high-performance liquid chromatography with fluorescence detection

Autor: Kenichi Sudo, Makoto Tanaka, Shuko Tachibana, Aiko Fukano

Publikováno v: Journal of chromatography. B, Biomedical sciences and applications. 734(1)

A high-performance liquid chromatographic method for the determination of a novel calmodulin antagonist, 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-( 4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate, DY-9760e an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e090c34069b330ef4a6ac39a47e21c
https://pubmed.ncbi.nlm.nih.gov/10574188

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