Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Shuke Nie"'
Autor:
Xingyu Zhang, Li Zou, Li Tang, Min Xiong, Xiao-Xin Yan, Lanxia Meng, Guiqin Chen, Jing Xiong, Shuke Nie, Zhaohui Zhang, Qiang Chen, Zhentao Zhang
Publikováno v:
PLoS Biology, Vol 22, Iss 1 (2024)
Externí odkaz:
https://doaj.org/article/e0ff0fbafbd9416aa99275a70842e6fc
Publikováno v:
Frontiers in Public Health, Vol 11 (2024)
ObjectiveThis study aims to develop and validate a prediction model for evaluating the social participation in the community middle-aged and older adult stroke survivors.MethodsThe predictive model is based on data from the China Health and Retiremen
Externí odkaz:
https://doaj.org/article/ba6aa3be0feb45cca1bfb1277776852a
Cholestanol accelerates α-synuclein aggregation and spreading by activating asparagine endopeptidase
Autor:
Ting Yu, Shuke Nie, Lihong Bu, Miao Liu, Juanfeng He, Xuan Niu, Hongyan Feng, Jifeng Guo, Beisha Tang, Zhaohui Zhang, Keqiang Ye, Haiqiang Jiang, Liam Chen, Zhentao Zhang
Publikováno v:
JCI Insight, Vol 8, Iss 21 (2023)
Cerebrotendinous xanthomatosis (CTX), an autosomal recessive disorder characterized by high levels of cholestanol in the blood and accumulation of cholestanol in multiple tissues, especially the brain, often presents in parkinsonism. However, it rema
Externí odkaz:
https://doaj.org/article/955afeea90bf46348fadccd5ba1ffd28
Autor:
Cong Zheng, Yan Xu, Guiqin Chen, Yang Tan, Weiqi Zeng, Ji Wang, Chi Cheng, Xiaoman Yang, Shuke Nie, Zhentao Zhang, Xuebing Cao
Publikováno v:
Neurobiology of Disease, Vol 139, Iss , Pp 104807- (2020)
L-DOPA-induced dyskinesia (LID) is a major complication of long-term dopamine replacement therapy in Parkinson's disease. Characteristic neural oscillation and abnormal activity of striatal projection neurons (SPNs) are typical pathological events of
Externí odkaz:
https://doaj.org/article/b9b04b69a96d49deb683e0e61c33dd27
Autor:
Yang Tan, Yan Xu, Chi Cheng, Cong Zheng, Weiqi Zeng, Ji Wang, Xiaoqian Zhang, Xiaoman Yang, Jialing Wang, Xiaomei Yang, Shuke Nie, Xuebing Cao
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Glutamate overactivity in basal ganglia critically contributes to the exacerbation of dopaminergic neuron degeneration in Parkinson’s disease (PD). Activation of group II metabotropic glutamate receptors (mGlu2/3 receptors), which can decrease exci
Externí odkaz:
https://doaj.org/article/1f6b57fd956840608a775f08182c3433
Autor:
Shuke Nie, Kai Ma, Mingkuan Sun, Matthew Lee, Yang Tan, Guiqin Chen, Zhentao Zhang, Zhaohui Zhang, Xuebing Cao
Publikováno v:
Parkinson's Disease, Vol 2019 (2019)
7,8-Dihydroxyflavone (7,8-DHF) is thought to be a promising therapeutic agent for various neurodegenerative diseases. The major purpose of this study was to investigate the neuroprotective effects of 7,8-DHF on the rotenone-induced motor deficit of P
Externí odkaz:
https://doaj.org/article/ee5c4a4c01294ded8c42637241a79757
Autor:
Cong Zheng, Guiqin Chen, Yang Tan, Weiqi Zeng, Qiwei Peng, Ji Wang, Chi Cheng, Xiaoman Yang, Shuke Nie, Yan Xu, Zhentao Zhang, Stella M. Papa, Keqiang Ye, Xuebing Cao
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Dopaminergic neurons loss is one of the main pathological characters of Parkinson’s disease (PD), while no suitable neuroprotective agents have been in clinical use. Thyrotropin-releasing hormone (TRH) and its analogs protect neurons from ischemia
Externí odkaz:
https://doaj.org/article/ce3deacd3ee548c298fa190d2309cb6e
Autor:
Cong Zheng, Guiqin Chen, Yang Tan, Weiqi Zeng, Qiwei Peng, Ji Wang, Chi Cheng, Xiaoman Yang, Shuke Nie, Yan Xu, Zhentao Zhang, Stella M. Papa, Keqiang Ye, Xuebing Cao
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Thyrotropin-releasing hormone (TRH) and its analogs are able to stimulate the release of the endogenic dopamine (DA) in the central nervous system. However, this effect has not been tested in the Parkinson’s disease (PD), which is characterized by
Externí odkaz:
https://doaj.org/article/473d9bb7619f49248bdfaf9e1f76cbb7
Autor:
Shuke Nie, Yang Tan, Zhentao Zhang, Guiqin Chen, Jing Xiong, Dan Hu, Keqiang Ye, Yunjian Zhang, Xuebing Cao, Liam Chen, Zhaohui Zhang
Publikováno v:
Frontiers in Aging Neuroscience, Vol 10 (2018)
Vascular cognitive impairment (VCI) encompasses all causes of cerebrovascular disease that lead to cognitive decline, or overt dementia, atherosclerotic disease being the most common contributor. However, few rodent models that mimic the pathology of
Externí odkaz:
https://doaj.org/article/0ac8560d78824ebfab4ac92a2b8873a6
Publikováno v:
Frontiers in Neuroscience, Vol 11 (2017)
L-DOPA-induced dyskinesia (LID) represents one of the major problems of the long-term therapy of patients with Parkinson's disease (PD). Although, the pathophysiologic mechanisms underlying LID are not completely understood, activation of the extrace
Externí odkaz:
https://doaj.org/article/17d936edc07b4b95bfc9a694419bcf41