Zobrazeno 1 - 10
of 312
pro vyhledávání: '"Shuk-Han Cheng"'
Autor:
Xudong Lin, Xin Duan, Claire Jacobs, Jeremy Ullmann, Chung-Yuen Chan, Siya Chen, Shuk-Han Cheng, Wen-Ning Zhao, Annapurna Poduri, Xin Wang, Stephen J. Haggarty, Peng Shi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
A major goal in neuropharmacology is to develop new tools to effectively test the therapeutic potential of pharmacological agents to treat neurological and psychiatric conditions. Here, authors present an in vivo drug screening system that generates
Externí odkaz:
https://doaj.org/article/709f8352b59f4f82a66f22e89e4f510e
Autor:
Xuan Luo, Yanyun Ding, Yi Cao, Zhen Liu, Wenchong Zhang, Shangzhi Zeng, Shuk Han Cheng, Honglin Li, Stephen J. Haggarty, Xin Wang, Jin Zhang, Peng Shi
Publikováno v:
iScience, Vol 27, Iss 10, Pp 110875- (2024)
Summary: In this study, we present an approach to neuropharmacological research by integrating few-shot meta-learning algorithms with brain activity mapping (BAMing) to enhance the discovery of central nervous system (CNS) therapeutics. By utilizing
Externí odkaz:
https://doaj.org/article/278cb6cb166b496e8a1de594942c5c13
Autor:
Guopan Liu, Ying Wang, Yilin Pan, Li Tian, Ming Ho Choi, Li Wang, Jin Young Kim, Jian Zhang, Shuk Han Cheng, Liang Zhang
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Background Recent studies demonstrated that elevated osmolarity could induce adipocyte dedifferentiation, representing an appealing procedure to generate multipotent stem cells. Here we aim to elucidate the molecular mechanisms that underlie
Externí odkaz:
https://doaj.org/article/2bc579bd993d462390fc40613a3b4c76
Autor:
Gary Tse, Jiandong Zhou, Xiuming Dong, Guoliang Hao, Sharen Lee, Keith Sai Kit Leung, Fung Ping Leung, Tong Liu, Yimei Du, Shuk Han Cheng, Wing Tak Wong
Publikováno v:
International Journal of Arrhythmia, Vol 24, Iss 1, Pp 1-11 (2023)
Abstract Background Previous studies have quantified repolarization variability using time-domain, frequency-domain and nonlinear analysis in mouse hearts. Here, we investigated the relationship between these parameters and ventricular arrhythmogenic
Externí odkaz:
https://doaj.org/article/d546adc208d84bbcb6f6755fb7ad4e80
Autor:
Muhammad Shehzad Khan, Rachit Kumar, Sinai H.C. Manno, Irfan Ahmed, Alan Wing Lun Law, Raul R. Cruces, Victor Ma, William C. Cho, Shuk Han Cheng, Condon Lau
Publikováno v:
Heliyon, Vol 6, Iss 4, Pp e03702- (2020)
Silicon-based devices, such as neural probes, are increasingly used as electrodes for receiving electrical signals from neural tissue. Neural probes used chronically have been known to induce inflammation and elicit an immune response. The current st
Externí odkaz:
https://doaj.org/article/b152c942174b442b8618bb76fd667c97
Autor:
Sinai H C Manno, Francis A M Manno, Li Tian, Muhammad S Khan, Irfan Ahmed, Yuanchao Liu, Vincent W T Li, Shisan Xu, Fangjing Xie, Tak Fu Hung, Victor Ma, William Cho, Beatriz Aldape, Shuk Han Cheng, Condon Lau
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0244542 (2020)
Tea is a popular beverage consumed at different temperatures. The effect of tea on teeth at different temperatures has not been studied previously. The present study used an in vitro green tea immersed tooth model at different tea temperatures (hot a
Externí odkaz:
https://doaj.org/article/3afe651f2f7648e89178827189e2e1ab
Autor:
Francis A. M. Manno, Arturo G. Isla, Sinai H. C. Manno, Irfan Ahmed, Shuk Han Cheng, Fernando A. Barrios, Condon Lau
Publikováno v:
Frontiers in Aging Neuroscience, Vol 11 (2019)
Alzheimer’s disease (AD) is characterized in the late stages by amyloid-β (Aβ) plaques and neurofibrillary tangles. Nevertheless, recent evidence has indicated that early changes in cerebral connectivity could compromise cognitive functions even
Externí odkaz:
https://doaj.org/article/3728f83feb304600b3d481ca791fec3d
Autor:
Gary Tse, Yimei Du, Guoliang Hao, Ka Hou Christien Li, Fiona Yin Wah Chan, Tong Liu, Guangping Li, George Bazoukis, Konstantinos P. Letsas, William K. K. Wu, Shuk Han Cheng, Wing Tak Wong
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Background: Beat-to-beat variability in action potential duration (APD) is an intrinsic property of cardiac tissue and is altered in pro-arrhythmic states. However, it has never been examined in mice.Methods: Left atrial or ventricular monophasic act
Externí odkaz:
https://doaj.org/article/63078bbb713040e99b27a1cc71ae4f6f
Autor:
Shisan Xu, Gary Tse, Fangjing Xie, Kin Fung Wong, Li Tian, Kazi Md Mahmudul Hasan, Shuk Han Cheng, Lei Sun, Alvin C.H. Ma, Yingying Lu, Jianbo Yue, Sinai H. C. Manno
Publikováno v:
npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-13 (2021)
NPJ Regenerative Medicine
NPJ Regenerative Medicine
Metformin is one of the most widely used drugs for type 2 diabetes and it also exhibits cardiovascular protective activity. However, the underlying mechanism of its action is not well understood. Here, we used an adult zebrafish model of heart cryoin
Autor:
Cheuk To Chung, Oscar Hou In Chou, Teddy Tai Loy Lee, Danny Radford, Kamalan Jeevaratnam, Wing Tak Wong, Shuk Han Cheng, Ngai Shing Mok, Tong Liu, Gary Tse, Sharen Lee
IntroductionThe understanding of healthcare resource utilisation and its related costs is crucial for optimizing resource allocation in the healthcare setting. There is currently a paucity of published studies investigating healthcare costs related t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1488edaee0d876102ea3bbb72d49e9ab
https://doi.org/10.1101/2022.11.12.22282256
https://doi.org/10.1101/2022.11.12.22282256