Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Shuji Teramoto"'
Autor:
Michiaki Tominaga, Kazuo Sekiguchi, Nakayama Sunao, Hidenori Ogawa, Yoshihisa Tanada, Takumi Sumida, Shigeki Nakamura, Takahiro Hirano, Keizo Kan, Shuji Teramoto, Shuji Itoh, Kazumi Kondo, Yoshitaka Yamamura, Masashi Aoyama, Toshimi Kambe, Tsujimae Kenji, Gozoh Tsujimoto, Toyoki Mori, Shinohara Tomoichi
Publikováno v:
British Journal of Pharmacology. 129:1700-1706
We discovered the first nonpeptide arginine-vasopressin (AVP) V(2)-receptor agonist, OPC-51803. Pharmacological properties of OPC-51803 were elucidated using HeLa cells expressing human AVP receptor subtypes (V(2), V(1a) and V(1b)) and compared with
Autor:
Hiroyuki Fujiki, Toyoki Mori, Kriton Iakovou, Shuji Teramoto, Maria R. Romeo, Giancarlo Bruni, Michalis Kazanis, Andreas Vavayannis, Paola Massarelli
Publikováno v:
European Journal of Medicinal Chemistry. 34:903-917
Aseries of oxypropanolamine derivatives of 3,4-dihydro-2H-1,4-benzoxazine were synthesized and evaluated for inotropic, chronotropic and coronary vasodilating activities in the canine heart, affinity to beta(1)-adrenergic receptor in turkey erythrocy
Autor:
Dana E. Vanderwall, Xue-Jun Tang, Christopher J. Turner, Dale L. Boger, Silvia T. Hoehn, Siu Man Lui, Shuji Teramoto, Wei Wu, John W. Kozarich, JoAnne Stubbe
Publikováno v:
Journal of the American Chemical Society. 120:2239-2250
NMR studies of the hydroperoxide form of cobalt deglycoBleomycin A2 (HOO−CodGBLM) and its complex with oligonucleotide d(CCAGGCCTGG) (1, C is the site of cleavage) are presented in an effort to establish deglycoBLM as a prototype for studies with B
Publikováno v:
Journal of the American Chemical Society. 117:7344-7356
Publikováno v:
Journal of the American Chemical Society. 117:7338-7343
Autor:
Takafumi Fujioka, Takumi Sumida, Tetsumi Hosokawa, Shuji Teramoto, Youichi Yabuuchi, Michiaki Tominaga, Toyoki Mori
Publikováno v:
ChemInform. 24
A series of 6-(3-amino-2-hydroxypropoxy)-2(1H)-quinolinones has been synthesized and evaluated for positive inotropic activity on the canine heart. Some of these derivatives have a potent activity with none or negative chronotropic effect in isolated
Autor:
Kazumi Takemoto, Youichi Yabuuchi, Michiaki Tominaga, Toyoki Mori, Takafumi Fujioka, Sachiko Tsujimi, Tetsumi Hosokawa, Shuji Teramoto, Takumi Sumida
Publikováno v:
ChemInform. 28
The enantiomers of 6-[3-(3,4-dimethoxybenzylamino)-2-hydroxypropoxy]-2(1H)-quinolinon e (OPC-18790), a novel cardiotonic agent, were synthesized and evaluated for positive inotropic activity. The key intermediates, 2,3-epoxypropoxy derivatives, were
Autor:
Hiroyuki Fujiki, Paola Massarelli, Kriton Iakovou, Toyoki Mori, Maria R. Romeo, Shuji Teramoto, Michalis Kazanis, Andreas Vavayannis, Giancarlo Bruni
Publikováno v:
ChemInform. 31
Aseries of oxypropanolamine derivatives of 3,4-dihydro-2H-1,4-benzoxazine were synthesized and evaluated for inotropic, chronotropic and coronary vasodilating activities in the canine heart, affinity to β1-adrenergic receptor in turkey erythrocytes
Autor:
Youichi Yabuuchi, Michiaki Tominaga, Shuji Teramoto, Takumi Sumida, Tetsumi Hosokawa, Toyoki Mori, Takafumi Fujioka
Publikováno v:
Journal of Medicinal Chemistry. 35:3607-3612
A series of 6-(3-amino-2-hydroxypropoxy)-2(1H)-quinolinones has been synthesized and evaluated for positive inotropic activity on the canine heart. Some of these derivatives have a potent activity with none or negative chronotropic effect in isolated
Autor:
Tetsumi Hosokawa, Takafumi Fujioka, Michiaki Tominaga, Shuji Teramoto, Toyoki Mori, Takumi Sumida, Kazumi Takemoto, Sachiko Tsujimi, Youichi Yabuuchi
Publikováno v:
Chemical and Pharmaceutical Bulletin. 44:1596-1598
The enantiomers of 6-[3-(3,4-dimethoxybenzylamino)-2-hydroxypropoxy]-2(1H)-quinolinon e (OPC-18790), a novel cardiotonic agent, were synthesized and evaluated for positive inotropic activity. The key intermediates, 2,3-epoxypropoxy derivatives, were