Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Shuji Sonda"'
Autor:
Hiroshi Sakashita, Yoshiharu Hayashi, Mika Nabeno, Masahiro Takeuchi, Hiroyuki Kishida, Yoshihito Tanaka, Shuji Sonda, Ikuko Miyaguchi, Tomohiro Yoshida, Fumihiko Akahoshi
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:5033-5041
Hypoglycemic agents with a mechanism of depeptidyl peptidase IV (DPP-4) inhibition are suitable for once daily oral dosing. It is difficult to strike a balance between inhibitory activity and duration of action in plasma for inhibitors bearing an ele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eecab8127cb1e896847bb3931113b436
https://doi.org/10.1016/j.bmc.2012.06.033
https://doi.org/10.1016/j.bmc.2012.06.033
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:2737-2747
A series of 4-amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamides with a polar substituent group at the 1-position of the piperidine ring was synthesized and evaluated for its effect on gastrointestinal motility. The benzoyl, phenylsulfonyl,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7df01712b23434e03328748c9c4a49ba
https://doi.org/10.1016/j.bmc.2004.02.036
https://doi.org/10.1016/j.bmc.2004.02.036
Publikováno v:
Bioorganic & Medicinal Chemistry. 11:4225-4234
A series of 4-amino-5-chloro-2-methoxy- N -(piperidin-4-ylmethyl)benzamide derivatives bearing an aralkylamino, alkylamino, benzoyl or phenylsulfonyl group at its side chain part at the 1-position on the piperidine ring was synthesized. They were eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7119f42a3d7778509b2fe16fcc02c38b
https://doi.org/10.1016/s0968-0896(03)00412-7
https://doi.org/10.1016/s0968-0896(03)00412-7
Autor:
Katsuhiko Itoh, Keiichiro Haga, Shuji Sonda, Masatake Fujimura, Takeshi Kawakita, Kiyoshi Asano, Noriko Sato, Hidetoshi Hakira, Hideo Tomozane
Publikováno v:
European Journal of Medicinal Chemistry. 34:1101-1108
Aseries of 4-amino-5-chloro-2-methoxy-N-(1-substituted piperidin-4-ylmethyl)benzamides was synthesized as novel gastroprokinetic agents. The affinity of these compounds for the 5-hydroxytryptamine 4 (5-HT4) receptor was evaluated. Among these compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::496fbe0f15967bf09f33c5fbae276ac7
https://doi.org/10.1016/s0223-5234(99)00125-7
https://doi.org/10.1016/s0223-5234(99)00125-7
Autor:
Takeshi Kawakita, Shuji Sonda, Koji Kanzaki, Keiichiro Haga, Takanobu Kuroita, Katsuhiko Itoh, Noriko Sato, Hideo Tomozane, Tsuguo Ikebe
Publikováno v:
European Journal of Medicinal Chemistry. 34:977-989
A number of new carboxamide derivatives were synthesized. The affinity of these compounds for the serotoninergic 5-HT(4) receptor was evaluated by use of radioligand-binding techniques. The agonistic activity was evaluated as the contractile effect o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d6b155b250cb35ff1c20be761036b3
https://doi.org/10.1016/s0223-5234(99)00158-0
https://doi.org/10.1016/s0223-5234(99)00158-0
Autor:
Takayuki Ishige, Hiroyuki Kishida, Sumie Sekiguchi, Yoshihito Tanaka, Yuji Abe, Yoshinobu Nakamaru, Ikuko Miyaguchi, Hiroshi Kitajima, Keigo Kosaka, Kumiko Yoshida, Reiko Tsutsumiuchi, Naoko Ueda, Mika Nabeno, Masahiro Takeuchi, Shinichi Ishii, Yoko Takashina, Hiroyuki Utsumi, Tomohiro Yoshida, Satoko Kiuchi, Yoshiharu Hayashi, Kyoko Shima, Shuji Sonda, Aki Soejima, Naoya Masutomi, Jun Anabuki, Fukuda Sayaka, Hiroshi Sakashita, Mitsuharu Nakamura, Takahiro Murozono, Fumihiko Akahoshi
Publikováno v:
Bioorganicmedicinal chemistry. 20(19)
Dipeptidyl peptidase IV (DPP-4) inhibition is suitable mechanism for once daily oral dosing regimen because of its low risk of hypoglycemia. We explored linked bicyclic heteroarylpiperazines substituted at the γ-position of the proline structure in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::886f16383bee6e2ced6da2f121e178d6
https://pubmed.ncbi.nlm.nih.gov/22959556
https://pubmed.ncbi.nlm.nih.gov/22959556
Autor:
Masatake Fujimura, Shuji Sonda, Noriko Sato, Keiichiro Haga, Kiyoshi Asano, Hidetoshi Hakira, Hideo Tomozane, Takeshi Kawakita, Katsuhiko Itoh
Publikováno v:
ChemInform. 31
Aseries of 4-amino-5-chloro-2-methoxy-N-(1-substituted piperidin-4-ylmethyl)benzamides was synthesized as novel gastroprokinetic agents. The affinity of these compounds for the 5-hydroxytryptamine 4 (5-HT4) receptor was evaluated. Among these compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91d88668156ce957bf563eca86871562
https://doi.org/10.1002/chin.200018171
https://doi.org/10.1002/chin.200018171
Autor:
Kenichi Inaba, Kiyoshi Asano, Ken-ichi Katayama, Shuji Sonda, Masakazu Fujio, Toshiaki Akira, Hiroshi Sakashita
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(4)
The structure–activity relationships of novel 1,5-benzodioxepin derivatives as muscarinic M1–M3 receptor antagonists are reported. Some of these compounds were found to possess high binding affinity for the muscarinic M3 receptor and potent effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57891ebd81ed5ab9b2ea4b10a9e156f1
https://pubmed.ncbi.nlm.nih.gov/17188867
https://pubmed.ncbi.nlm.nih.gov/17188867
Publikováno v:
Bioorganicmedicinal chemistry. 13(9)
It is thought that selective 5-HT 4 receptor agonists—such as 4-amino-5-chloro-2-methoxy- N -[1-(6-oxo-6-phenylhexyl)piperidin-4-ylmethyl]benzamide ( 2 )—have the ability to enhance both upper and lower gastrointestinal motility without any signi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d297e6b28c6c762912c87af83e19f0
https://pubmed.ncbi.nlm.nih.gov/15809165
https://pubmed.ncbi.nlm.nih.gov/15809165
Publikováno v:
Journal of the Chemical Society, Chemical Communications. :1329
Mono-, di- and tri-hydroxy[2.4]metacyclophanes 1 have been prepared and their modes of hydrogen bonding characterized.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::182af66f546c5bfc49bd997a0ee2cf59
https://doi.org/10.1039/c39910001329
https://doi.org/10.1039/c39910001329