Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Shuji Kitamura"'
Autor:
Sachio Shibata, Satoshi Sogabe, Masanori Miwa, Takuya Fujimoto, Nobuyuki Takakura, Akihiko Naotsuka, Shuji Kitamura, Tomohiro Kawamoto, Tomoyoshi Soga
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Lactate dehydrogenase (LDH) catalyses the conversion of pyruvate to lactate and NADH to NAD+; it has two isoforms, LDHA and LDHB. LDHA is a promising target for cancer therapy, whereas LDHB is necessary for basal autophagy and cancer cell pr
Externí odkaz:
https://doaj.org/article/f9c30a90aae44dd1abe0ffa04ef29aac
Autor:
Satoshi Mizuta, Hiroki Otaki, Takeshi Ishikawa, Juliann Nzembi Makau, Tomoko Yamaguchi, Takuya Fujimoto, Nobuyuki Takakura, Nobuki Sakauchi, Shuji Kitamura, Hikaru Nono, Ryota Nishi, Yoshimasa Tanaka, Kohsuke Takeda, Noriyuki Nishida, Ken Watanabe
Publikováno v:
Journal of Medicinal Chemistry. 65:369-385
Influenza viruses are responsible for contagious respiratory illnesses in humans and cause seasonal epidemics and occasional pandemics worldwide. Previously, we identified a quinolinone derivative
Autor:
Tomoyoshi Soga, Satoshi Sogabe, Takuya Fujimoto, Tomohiro Kawamoto, Nobuyuki Takakura, Shuji Kitamura, Masanori Miwa, Sachio Shibata, Akihiko Naotsuka
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Lactate dehydrogenase (LDH) catalyses the conversion of pyruvate to lactate and NADH to NAD+; it has two isoforms, LDHA and LDHB. LDHA is a promising target for cancer therapy, whereas LDHB is necessary for basal autophagy and cancer cell proliferati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4268160f6405b1c33fef5e186d4693a5
https://doi.org/10.21203/rs.3.rs-95794/v1
https://doi.org/10.21203/rs.3.rs-95794/v1
Autor:
Akio Mizutani, Yoshinori Satomi, Masahiro Yaguchi, Yasuhiro Hirata, Kazunobu Aoyama, Atsushi Kiba, Bunnai Saito, Megumi Hirayama, Takuto Kojima, Shinichi Imamura, Tzu-Tshin Wong, Yasufumi Miyamoto, Kazuko Yonemori, Yuta Tanaka, Ryosuke Arai, Osamu Sano, Osamu Kurasawa, Yasutomi Asano, Naoki Iwamura, Yuto Hiura, Shuji Kitamura, Ryutaro Adachi, Sachio Shibata, Yoji Sagiya
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:2452-2465
We pursued serine palmitoyltransferase (SPT) inhibitors as novel cancer therapeutic agents based on a correlation between SPT inhibition and growth suppression of cancer cells. High-throughput screening and medicinal chemistry efforts led to the iden
Autor:
Satoshi Mizuta, Hiroki Otaki, Takeshi Ishikawa, Makau, Nzembi, Juliann, Tomoko Yamaguchi, Takuya Fujimoto, Nobuyuki Takakura, Nobuki Sakauchi, Shuji Kitamura, Hikaru Nono, Ryota Nishi, Yoshimasa Tanaka, Kohsuke Takeda, Noriyuki Nishida, Ken Watanabe
Publikováno v:
Journal of Medicinal Chemistry; 1/13/2022, Vol. 65 Issue 1, p369-385, 17p
Autor:
Shuji Kitamura, Nobuyuki Negoro, Nobuhiro Suzuki, Tsuneo Yasuma, Yu Momose, Masami Suzuki, Naoyuki Kanzaki, Satoshi Mikami, Takashi Santou, Ryo Ito, Shinobu Sasaki, Takeshi Miyazaki, Junichi Miyazaki, Yoshiyuki Tsujihata, Toshimasa Tanaka, Miyuki Funami
Publikováno v:
Journal of Medicinal Chemistry. 55:3756-3776
As part of a program to identify potent GPR40 agonists with drug-like properties suitable for clinical development, the incorporation of polar substituents was explored with the intention of decreasing the lipophilicity of our recently disclosed phen
Autor:
Tsuneo Yasuma, Masami Suzuki, Yasuhiro Tanaka, Makoto Kobayashi, Miyuki Funami, Takashi Santou, Toshimasa Tanaka, Kohji Fukatsu, Nobuhiro Suzuki, Shinobu Sasaki, Yoshio Yamamoto, Yoshiyuki Tsujihata, Naoyuki Kanzaki, Masataka Harada, Nobuyuki Negoro, Yu Momose, Norio Tada, Shuji Kitamura
Publikováno v:
Journal of Medicinal Chemistry. 54:1365-1378
G protein-coupled receptor 40 (GPR40) is being recently considered to be a new potential drug target for the treatment of type 2 diabetes because of its role in the enhancement of free fatty acid-regulated glucose-stimulated insulin secretion in panc
Autor:
Scott Alan Pratt, Yoshihisa Nakada, Shuji Kitamura, Thomas Daniel Aicher, Toshihiro Yamamoto, Hiroshi Miki, Hiroshi Yamaguchi, Koki Kato
Publikováno v:
European Journal of Pharmacology. 650:663-672
Obesity is characterized by the accumulation of triacylglycerol in adipocytes. Coenzyme A:diacylglycerol acyltransferase 1 (DGAT1) is one of two known DGAT enzymes that catalyze the final and only committed step in triacylglycerol synthesis. In this
Autor:
Steve A. Boyd, Shuji Kitamura, Thomas Daniel Aicher, Koki Kato, Yoshihisa Nakada, Turner Timothy M, Scott Alan Pratt, Hiroshi Yamaguchi, Hiroshi Miki, Stephen S. Gonzales, Toshihiro Yamamoto, Yvan Le Huerou
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:2785-2795
A series of diacylethylenediamine derivatives were synthesized and evaluated for their inhibitory activity against DGAT-1 and pharmacokinetic profile to discover new small molecule DGAT-1 inhibitors. Among the compounds, N-[2-({[1-phenyl-3-(trifluoro
Autor:
Hiroyuki Kimura, Taiichi Ohra, Satoshi Sogabe, Shin-ichi Matsumoto, Masahiro Kajino, Hideki Igata, Masashi Yamaguchi, Shuji Kitamura, Toshimasa Tanaka, Tomohiro Kawamoto, Shota Ikeda, Shoji Fukumoto, Fumio Itoh, Yasutomi Asano, Manami Kaneko, Tomoko Tamura
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:4699-4714
3-Metoxycarbonyl isoquinolone derivative 1 has been identified as a potent JNK inhibitor and significantly inhibited cardiac hypertrophy in a rat pressure-overload model. Herein, a series of isoquinolones with an imidazolylmethyl or a pyrazolylmethyl